ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.
Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.
Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.
The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.
Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more
|THYROID Sympathetic Ciprofloxacin glycine foods Nervous Parasites heavymetals, epinephrine 4q27Region GABA Immune OAT aspartate Livewello Levaquin adrenal excitotoxins ammonia aspartic thyroid homogenized homocysteine asthma ACE phytic titers VitaminE nucleotide sulfur Ofloxacin Pancreatic methyl mercury. insomnia Geneticists Xylitol electrolytes Riboflavin hypotension 5-MTHF cyclin lymphoma LIVER neurological respiratory fibromyalgia aluminum molybdenum Metabolic SNS Cipro progesterone depressed CitricAcidCycle Flavoproteins B1 B2 cholesterol HPylori. obesity rheumatoid 23andMe quinolinic Deplin VDR lethargy constipation Illumina unpasteurized shmt almond Folic Folate Heterozygous methylcobalamin ALA Floxin bacteria depression viral APOE Dominant Gluten Paxil psychosomatic anticarcinogenics sinusitus spelt) milk vaccines juicer Amazon health digestive flushing glutamine METHIONINE ROS HNMT Strand LowFat niacin Lifestyle cauliflower Anthocyanins MuscleTesting DOCTORS catabolic neuroimmune Supplements detoxification NMDA oxidative testosterone, SampleGeneReport Rheumatoid Deodorants ME epigenetics Saturated testosterone methylation SNPs App hypoglycemia Epinephrine catechins SSRI CBS Cytopathy supplements Raynaud’ Thyroid LiveWello toxicity Adrenalin NOS kamut plastics Avelox cancer heart anxiety, Norepinepherine antioxidant cruciferous Levofloxacin Excitotoxins A1298C chronic MTRR ACAT B12 leukemia ADHD Dopamine, Crohn's Athritis SAD mental sympathetic AdenosylB12 HOMOCYSTEINE BHMT Lactoferrin LMethylFolate C677T cancer, B12, Diet Histamine MTRR MethylTetraHydroFolateReductase genetic 2 parasites, Liver memory dieoff Melatonin, MERCURY nutrition digestion DNA gluten overmethylated, inflammatory bowel Mitochondria psychiatric COMT creatinine Homozygous Zoloft Calcium antibiotics UTMEE liver Guernsey thiol RNA Gene adrenals KIDNEY anemia, gut PlusStrand anxiety phenols toxins SNRI yeasts VDRFok lhistamine parasympathetic myalgic pneumonia gutinflammation Supplement cancers Candida undermethylators Potassium allergic Neurotransmitters Glutamate 5-10-MethyleenTetraHydroFolate aspartame) autoimmune estrogen bronchitis Glutamic glutamic FolicAcid metals Lyme stroke hormone ForwardStrand eczema MSG sarcoma Neurotransmitter IBS neurotransmitters BH4 kidney cadmium melanoma miscarriages carcinogenic Food allergies Genes uranium NeeVoDHA glutamate 1 MTHFR mercury chromosome hormones FMT FAD FowardStrand junk Raynaud FRa glutamates Spirulina Methylation MTR L-Methyl T4 L-MethylFolate Parasympathetic Oxalates SAMe UTM Hypokalemia norepinephrine Moxifloxacin fatigue ADHD) worm Autonomic detox P5P broccoli mao diabetes stress gene Autoimmune EnergyCycle neuropathy nickel insomnia, PNS apathy apolipoprotein ADD Autism Adducin heavymetals Mitochondrial Casein T3 MAOA SUOX divide AHCY MCS CFS disorganization Magnesium|