Folic ACID will get turned into Dihydrofolate and will be all gone... except for any more you may eat due to eating many fortified cereals and bread products.
A little Folic ACID will not be a problem. The problems occur when the amount of Folic ACID outweighs the availability of L-Methyl Folate regarding the BRAIN since Folic ACID blocks up the #L-Methyl Folate [ #5-MTHF ] #Folate Receptor Alpha receptors and prevents the real thing [5-MTHF] from getting into the brain.
The rest of the body doesn't suffer from too much #Folic ACID....only the brain.
Folic ACID is synthetic and can get stuck in the L-methyl folate receptor sites on our Blood Brain Barrier [BBB] and if the Folic ACID level is greater than the L-methyl folate level then the real thing [L-Methyl Folate] cannot get into our brain.
It is the Folic ACID which is synthetic and is NOT found in natural foods.
BUT, the government has required Folic ACID be added to many processed foods...but it is NOT NATURAL. Folic ACID is not found in nature.
Those with the MTHFR mutation[s] cannot make adequate amounts of L-Methyl folate if the Folic ACID floating around in the blood stream out weighs it. If the ratio is backwards then the L-methyl Folate Receptor sites on the Blood Brain Barrier can get all stuffed up with Folic ACID, and the real thing [L-Methyl Folate] will be blocked from entering the brain. This is the significant primary problem related to Folic ACID.
Calcium #folinate is just another term for #Folinic acid or Rx #Leukovorin. It is turned into the precursor molecule 5-10 methyleneTHF which then needs to be converted into L-methyl folate by the enzyme #MTHFR.
The other issue is that Folic ACID is SYNTHETIC and can block up the L-methyl folate receptor sites on our Blood Brain Barrier [BBB]. None of the natural forms of folate block the L-methyl folate receptors on the BBB...only the synthetic Folic ACID can fit into the L-methyl folate receptors and block them up....thus preventing folate from entering the brain.
Those with a double copy of C677T or one copy of each C677T/A1298C will likely need L-Methyl folate for sure as those of us with those combinations can only make about 25-35% of the L-methyl folate that they need.
One copy of MTHFR C677T reduces the ability to produce L-methyl folate by 50% and those individuals will likely also do better if they take some L-methyl folate.
Folate is a generic term for all kinds of folate.
*Folic Acid is a synthetic form of folate.
1. Dihydrofolate [DHF] is the form of folate that comes from natural dark green leafy vegetables.
2. DHF is then converted into Tetrahydrofolate [THF]
3. THF is then converted into 5-10-MethyleneTHF.
4. 5-10-MethyleneTHFR can go in several different directions down alternative paths, but for the conversion of 5-10-MethyleneTHF into L-methyl folate [5-MTHF] we then come to the enzyme MTHFR which is the enzyme with the Single Nucleotide Polymorphisms #C677T and #A1298C that we are all always talking about.
If you know you have the MTHFR gene mutation[s] and your folate level is high, then maybe you may need:
1. Lithium Oratate [helps transport folate and B12 into cells]
2. Zinc [helps the next enzyme in the process]
3. Vitamin B12 [helps the next enzyme in the process]
The next step is to get the " #23andMe " Single Nucleotide Polymorphism testing done.
Pass this information on to others because the MTHFR gene mutations are very common; perhaps 40 -50% of Americans with European ancestry carry at least one copy of the MTHFR gene mutation[s].
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