Most folks who are Zinc and/or Magnesium deficient have a hard time with B6. That's one of the reasons why working on Minerals first is such an important first step for so many.
A phosphate group gets added to B6, by an enzyme that's Zinc dependent, to make P5P. Then, by another enzyme that's Mag dependent, it get changed back again. The body needs both forms. The brain actually uses B6 (not P5P) to make Neurotransmitters.
Wow. What a thread! My serum B6 was a bit over ref range. My OAT showed it to be low. So my doctor thinks I'm not processing or absorbing it. She started me on P5P, but I have to spread my 33 mg of it throughout the day, or else I get jitters and tingly extremities. I'm not sure my OAT was interpreted optimally. My mag RBC was 5.5 before I recently increased supplementation. I know I have some kind of source of lack with zinc, because starting that cured my chronic insomnia. I have brain inflammation, and need to do all I can to reduce it. Wow, all this is so complex.
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