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Q:  How can I learn some basic information about MTHFR and L-METHYL FOLATE

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDXs4QKDA MTHFR Question: How can I learn some basic information about MTHFR and L-METHYL FOLATE Answer: MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D. If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following: FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc. DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order to function. Other vegetables that include a good deal of natural DHF include: various kinds of beans, asparagus and brocholi.SUPPLEMENTING WITH... L-Methyl FolateL-methyl folate is not what we naturally eat. It is DiHydroFolate [DHF] that is primarily found in Greens and Beans. There now are several generic supplements with various amounts of L-Methyl Folate in them. At one time the amount of 5-MTHFR in non-prescription 5-MTHF was one mg or less. That fact has since changed, and supplements that are not prescription strength are in fact available now with 5mg or 10 mg in them. SUPPLEMENTATION WITH...Vitamin B12 People with Methionine Synthase Reductase [MTRR] snp mutations cannot transfer the methyl group form L-Methyl Folate onto "Naked" B12 [Cobalamin (I)] and these are the individuals who ususally need to supplement with Methyl-B12. But, those with COMT snps are usually sensitive to methyl donors and they do best if they take Adenyl-B12 or Hydroxy-B12 rather than Methyl-B12. VITAMIN B2 [Riboflavin] One of the Flavoproteins that Vitamin B2 is involved in making is FAD…Flavin Adenine Dinucleotide… [FAD/FADH2] is a rate limiting Cofactor for the enzyme MTHFR which makes L-Methyl Folate [5-MTHF]. FLAVOPROTEIN…definition A Flavoprotein is any of a class of conjugated proteins that contain flavins and are involved in oxidation reactions in cells. FLAVIN…definition Any of a group of yellow nitrogen-containing pigments, as riboflavin, that function as coenzymes. COENZYME…definition A coenzyme is a substance that enhances the action of an enzyme. [a coenzyme is a helper] ENZYME…definition An enzyme is a protein that functions as a catalyst to mediate and speedup a chemical reaction. AVOID extra FOLIC ACID if you have the MTHFR mutation[s] There is already plenty of Folic ACID in our processed foods. Folic ACID is a synthetic form of folate that can be converted into Dihydrofolate [DHF], but too much Folic ACID can get stuck in the Folate Receptor alpha [FRa] receptor sites on the Blood Brain Barrier [BBB]. Too much Folic ACID relative to the available L-Methyl Folate [5-MTHF] can prevent the real thing …L-Methyl Folate [5-MTHF]….from getting into the brain. ONLY L-methyl Folate can actually get into the brain through the BBB by way of the Folate Receptor alpha [FRa] receptors. This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways. The BLOOD BRAIN BARRIER [BBB]…definition The BLOOD BRAIN BARRIER [BBB] is a layer of tightly packed cells that make up the walls of brain capillaries and prevent substances in the blood from diffusing freely into the brain. The passage of substances across the cell membranes is determined by solubility in the lipid bilayer or recognition by a transport molecule [receptor]. THERE ARE MANY FORMS OF FOLATE The other many natural forms of folate [either eaten [DHF] or made by the body] do NOT get stuck in the FRa receptor sites…only Folic ACID and “Folate Receptor Auto-antibodies” can get stuck in the FRa receptors. THERE ARE SEVERAL DIFFERENT KINDS OF FOLATE RECEPTORS IN THE BODY Folate Receptor alpha [FRa] is the Folate receptor found on the BLOOD BRAIN BARRIER [BBB]. Too much FOLIC ACID and FOLATE Auto-ANTIBODIES…can be bad news When Folic ACID and or auto-antibodies against the FRa receptors get into the FRa receptors they can get stuck. When any of the NATURAL folates get into the FRa receptors on the BBB they can eventually disengage from the receptor and float away and the receptor is preserved for reuse. The supplement called Leukovorin [Folinic Acid] can also disengage and float away. LIGAND…definition The word ligand comes from the Latin word “ligandum” which means binding. A ligand [usually a small molecule] can form a complex with something else when it binds to the other object. TOO MUCH ….Folate ACID When Folic ACID [a synthetic man-made form of folate] gets attached to the FRa receptor on the BBB the complex becomes blocked. The Folic ACID molecule never gets into the brain and in the meantime it prevents the real thing [L-Methyl Folate] from getting into the brain. This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways. OTHER HELPFUL SUPPLEMENTS ZINC A little ZINC will help the Methionine Synthase [MS/MTR/MTRR] enzyme work to the best of their combined ability because Zinc is a necessary mineral that acts at the functional site of Methionine Synthase [MS/MTR]. The Zinc atom helps to coordinate all the participants in the reaction so that a methyl group gets attached to HOMOCYSTEINE thereby turning it into METHIONINE. LITHIUM ORATATE A little Lithium Oratate 2.5 to 5 mg a day will help B12 and folate get out of the blood stream and into our cells. A person may have a high B12 level in their blood stream but may not actually be getting that B12 or folate into their cells because of a lack of trace Lithium to be of assistance. Link to Post: https://www.facebook.com/editdoc.php?note_id=636743946415365 #MTHFR #L-METHYL FOLATE http://resqua.com/100005927200207/how-can-i-learn-some-basic-information-about-mthfr-and-l-methyl-folate

MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order to function. Other vegetables that include a good deal of natural DHF include: various kinds of beans, asparagus and brocholi.SUPPLEMENTING WITH... L-Methyl FolateL-methyl folate is not what we naturally eat. It is DiHydroFolate [DHF] that is primarily found in Greens and Beans. There now are several generic supplements with various amounts of L-Methyl Folate in them. At one time the amount of 5-MTHFR in non-prescription 5-MTHF was one mg or less. That fact has since changed, and supplements that are not prescription strength are in fact available now with 5mg or 10 mg in them. SUPPLEMENTATION WITH...Vitamin B12 People with Methionine Synthase Reductase [MTRR] snp mutations cannot transfer the methyl group form L-Methyl Folate onto "Naked" B12 [Cobalamin (I)] and these are the individuals who ususally need to supplement with Methyl-B12. But, those with COMT snps are usually sensitive to methyl donors and they do best if they take Adenyl-B12 or Hydroxy-B12 rather than Methyl-B12.

VITAMIN B2 [Riboflavin] One of the Flavoproteins that Vitamin B2 is involved in making is FAD…Flavin Adenine Dinucleotide… [FAD/FADH2] is a rate limiting Cofactor for the enzyme MTHFR which makes L-Methyl Folate [5-MTHF].

FLAVOPROTEIN…definition A Flavoprotein is any of a class of conjugated proteins that contain flavins and are involved in oxidation reactions in cells.

FLAVIN…definition Any of a group of yellow nitrogen-containing pigments, as riboflavin, that function as coenzymes.

COENZYME…definition A coenzyme is a substance that enhances the action of an enzyme. [a coenzyme is a helper]



ENZYME…definition An enzyme is a protein that functions as a catalyst to mediate and speedup a chemical reaction.

AVOID extra FOLIC ACID if you have the MTHFR mutation[s] There is already plenty of Folic ACID in our processed foods. Folic ACID is a synthetic form of folate that can be converted into Dihydrofolate [DHF], but too much Folic ACID can get stuck in the Folate Receptor alpha [FRa] receptor sites on the Blood Brain Barrier [BBB]. Too much Folic ACID relative to the available L-Methyl Folate [5-MTHF] can prevent the real thing …L-Methyl Folate [5-MTHF]….from getting into the brain. ONLY L-methyl Folate can actually get into the brain through the BBB by way of the Folate Receptor alpha [FRa] receptors.

This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways.

The BLOOD BRAIN BARRIER [BBB]…definition The BLOOD BRAIN BARRIER [BBB] is a layer of tightly packed cells that make up the walls of brain capillaries and prevent substances in the blood from diffusing freely into the brain. The passage of substances across the cell membranes is determined by solubility in the lipid bilayer or recognition by a transport molecule [receptor].

THERE ARE MANY FORMS OF FOLATE The other many natural forms of folate [either eaten [DHF] or made by the body] do NOT get stuck in the FRa receptor sites…only Folic ACID and “Folate Receptor Auto-antibodies” can get stuck in the FRa receptors.





THERE ARE SEVERAL DIFFERENT KINDS OF FOLATE RECEPTORS IN THE BODY Folate Receptor alpha [FRa] is the Folate receptor found on the BLOOD BRAIN BARRIER [BBB].

Too much FOLIC ACID and FOLATE Auto-ANTIBODIES…can be bad news When Folic ACID and or auto-antibodies against the FRa receptors get into the FRa receptors they can get stuck.

When any of the NATURAL folates get into the FRa receptors on the BBB they can eventually disengage from the receptor and float away and the receptor is preserved for reuse. The supplement called Leukovorin [Folinic Acid] can also disengage and float away.

LIGAND…definition The word ligand comes from the Latin word “ligandum” which means binding. A ligand [usually a small molecule] can form a complex with something else when it binds to the other object.

TOO MUCH ….Folate ACID When Folic ACID [a synthetic man-made form of folate] gets attached to the FRa receptor on the BBB the complex becomes blocked. The Folic ACID molecule never gets into the brain and in the meantime it prevents the real thing [L-Methyl Folate] from getting into the brain.

This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways.

OTHER HELPFUL SUPPLEMENTS

ZINC A little ZINC will help the Methionine Synthase [MS/MTR/MTRR] enzyme work to the best of their combined ability because Zinc is a necessary mineral that acts at the functional site of Methionine Synthase [MS/MTR]. The Zinc atom helps to coordinate all the participants in the reaction so that a methyl group gets attached to HOMOCYSTEINE thereby turning it into METHIONINE.

LITHIUM ORATATE A little Lithium Oratate 2.5 to 5 mg a day will help B12 and folate get out of the blood stream and into our cells. A person may have a high B12 level in their blood stream but may not actually be getting that B12 or folate into their cells because of a lack of trace Lithium to be of assistance.

Link to Post: https://www.facebook.com/ed...
#MTHFR #L-METHYL FOLATE

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