COMT and VDR Genes and DOPAMINE and NOREPINEPHERINE…and people sensitive to methyl donors.
Those with the Vitamin D Receptor Taq [VDR Taq (+/+)] mutations do not make Dopamine and therefore Norepinepherine very well.
Those with the Catechol-O-Methyl Transferase [COMT +/+] mutations cannot break down Dopamine and Norepinephrine very well.
A normal VDR [-/-] and the abnormal COMT [+/+] enzyme essentially aggravate the situation so that the concentration of Dopamine may be increased.
When the person has a perfect VDR taq [-/-] and they have the COMT [+/+] mutations then:
The good working VDR taq [-/-] allows them to make plenty of Dopamine.
The lousy COMT [+/+] causes ... ..more
By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"
The answer is... YES.
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more
MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]
The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.
L-Methyl Folate is most beneficial to ... ..more
SENSITIVITY TO METHYL DONORS By Carol Savage
Those who are very sensitive to methyl donors have to supplement with low dosages of different kinds of B12 and folate. Rotating them is likely the best approach.
They need to give their body TIME of accept the supplements, TIME to allow the biochemistry to adjust before adding in more...sometimes even skipping days when no supplements are taken.
A gentle approach is the best way to proceed if you are sensitive to methyl donors.
#Methyl Donors #MTHFR ..more
MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.
If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:
FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.
DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more
From Dr Carol Savage
Dr. Yasko may include the Folic ACID in some of her supplements...because there are perhaps individuals who never eat greens or beans, and whose gut is so messed up that they cannot digest greens or beans, and who avoid and never eat the processed foods that are already stuffed with Folic ACID.
The enzyme DiHydroFolate Reductase [DHFR] that converts DiHydroFolate [DHF] into THF can also convert Folic ACID into DHF.
If a person has a faulty "Folate Pathway" and is at risk for NOT making adequate DNA base pairs and they also have ... ..more
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