COMT and VDR Genes and DOPAMINE and NOREPINEPHERINE…and people sensitive to methyl donors.

Those with the Vitamin D Receptor Taq [VDR Taq (+/+)] mutations do not make Dopamine and therefore Norepinepherine very well.

Those with the Catechol-O-Methyl Transferase [COMT +/+] mutations cannot break down Dopamine and Norepinephrine very well.

A normal VDR [-/-] and the abnormal COMT [+/+] enzyme essentially aggravate the situation so that the concentration of Dopamine may be increased.

When the person has a perfect VDR taq [-/-] and they have the COMT [+/+] mutations then:

The good working VDR taq [-/-] allows them to make plenty of Dopamine.

The lousy COMT [+/+] causes them NOT to be able to inactivate Dopamine.

Consequently they have too much…. DOPAMINE and NOREPINEPHERINE.

These are the people who are frequently referred to as being sensitive to methyl groups because they are all hyped up with Dopamine and Norepinepherine.

ANOTHER WAY TO EXPLAIN IT
A VDR Taq that is normal [-/-] encourages the making of Dopamine and Norepinepherine. [SPEEDS UP PRODUCTION OF DOPAMINE

A COMT [+/+] slows down the inactivation of Dopamine and Norepinepherine. [PREVENTS THE BREAKDOWN OF DOPAMINE]

ANALOGY
So with more water [dopamine] enters the LAKE [brain], and a damn blocks the drainage [COMT [+/+]...then the water builds up [Dopamine] and your brain gets flooded with DOPAMINE and Norepinephrine and the person may feel nervous, jittery and may develop nightmares.

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#COMT #VDR Genes #methyldonors #Dopamine #Norepinepherine