MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]
The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.
L-Methyl Folate is most beneficial to the "Methylation Cycle"
MTHFR A1298C...FOLATE CYCLE...making of DNA bases
Meanwhile the MTHFR A1298C interferes with the reverse activity of the MTHFR enzyme...I do not understand precisely how this occurs. I do not know if anyone actually knows. But, consequently the MTHFR A1298C snps interferes more with the "Folate Cycle" rather than the "Methylation Cycle".
The Folinic acid is most beneficial to the "Folate Cycle".
The "Folate Cycle" is very important for making DNA bases. If the "Folate Cycle" is not working properly all manner of problems involved in proper and faithful replication of our DNA and RNA may occur. The ramifications are enormous and far reaching.
Link to Post: https://www.facebook.com/gr...
#FolateCycle #MTHFR #METHYLATION
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