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Q:  Why is my VDR Taq different on Livewello

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgMDk5owKDA Livewello FAQs Question: Why is my VDR Taq different on Livewello Answer: VDR Taq has a minor allele (MAF) of "G": http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs731236 Here are some studies that reference VDR Taq (rs731236): "We observed that women with GG (rs731236), ... were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism" http://www.ncbi.nlm.nih.gov/pubmed/25595352 "The VDR polymorphism, TaqI (rs731236), was associated with a 26 % risk reduction (TT vs. CC, OR 0.74)" http://www.ncbi.nlm.nih.gov/pubmed/25421379 All your results on LiveWello are determined using the Global Minor Allele Frequency (GMAF) value. All of LiveWello's Minor Allele information is retrieved directly from 1000 Genomes and dbSNP. A link is added to every SNP in a Livewello Gene Variance Report. That way, a user and their Practitioner can verify minor allele information for themselves. We only use the forward (FWD) strand for interpreting all our SNPs, because it is the same strand used by 23andMe, dbSNP & 1000 Genomes. Be aware that other reporting apps do not consistently do this, and will sometimes report minor alleles from the minus (REV) strand. Our goal at #Livewello is to make our gene variance reporting consistent and reproducible by using the same methodology for analyzing each and every SNP. We realize that there will still be those who would prefer to alter the allele information. For this, we have added the SNP Sandbox feature which is free with your Livewello Gene App. It gives users the ability to edit minor alleles to see what their phenotype would look like using different values. The intent of this feature is to offer flexibility as users utilize their Variance Application. It also offers users access to their results beyond the 300 SNPs in standard variance reports. Using SNP Sandbox & Gene Library, users can access their results for up to hundreds of thousands of SNPs. About Livewello's SNP Sandbox Tool: https://www.facebook.com/notes/livewello/about-livewellos-sandbox-tool/1108165612544602 Gene Library: https://livewello.com/snps/library 10 valuable resources for those who have done their 23andMe FTDNA or AncestryDNA test: https://docs.google.com/document/d/1-iy3WyhFDyzfUyVUfYVU1v2H45gwKPz1afUED22pwtI/edit?usp=sharing http://resqua.com/100005927200207/why-is-my-vdr-taq-different-on-livewello

VDR Taq has a minor allele (MAF) of "G":
http://www.ncbi.nlm.nih.gov...

Here are some studies that reference VDR Taq (rs731236):

"We observed that women with GG (rs731236), ... were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism"
http://www.ncbi.nlm.nih.gov...

"The VDR polymorphism, TaqI (rs731236), was associated with a 26 % risk reduction (TT vs. CC, OR 0.74)"
http://www.ncbi.nlm.nih.gov...

All your results on LiveWello are determined using the Global Minor Allele Frequency (GMAF) value. All of LiveWello's Minor Allele information is retrieved directly from 1000 Genomes and dbSNP. A link is added to every SNP in a Livewello Gene Variance Report. That way, a user and their Practitioner can verify minor allele information for themselves.

We only use the forward (FWD) strand for interpreting all our SNPs, because it is the same strand used by 23andMe, dbSNP & 1000 Genomes. Be aware that other reporting apps do not consistently do this, and will sometimes report minor alleles from the minus (REV) strand.

Our goal at #Livewello is to make our gene variance reporting consistent and reproducible by using the same methodology for analyzing each and every SNP.

We realize that there will still be those who would prefer to alter the allele information. For this, we have added the SNP Sandbox feature which is free with your Livewello Gene App. It gives users the ability to edit minor alleles to see what their phenotype would look like using different values. The intent of this feature is to offer flexibility as users utilize their Variance Application. It also offers users access to their results beyond the 300 SNPs in standard variance reports. Using SNP Sandbox & Gene Library, users can access their results for up to hundreds of thousands of SNPs.

About Livewello's SNP Sandbox Tool:
https://www.facebook.com/no...

Gene Library: https://livewello.com/snps/...

10 valuable resources for those who have done their 23andMe FTDNA or AncestryDNA test:
https://docs.google.com/doc...


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