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Q:  I have just received my 23andMe Gene Variance Report so I have my Gene Mutations, what should I do?

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDkv5kKDA 23andMe Test Results Question: I have just received my 23andMe Gene Variance Report so I have my Gene Mutations, what should I do? Answer: STEP ONE: Layering in The Foundation Knowing your Nervous system #dominance is an integral part in establishing the treatment process. A). Remove or limit triggers: Processed foods contain excitotoxins, dyes, and #toxic preservatives. It is also crucial to remove obvious food #allergies . Please see Resqua pages on #excitotoxins for more information. This is simply defined and discussed in detail. 
 
B). Begin general support: Provide a good foundation for your nervous system type and begin nutritional support. Though life threatening reactions would be extremely rare (and to my knowledge, unheard of), moving too quickly can result in more intense symptoms of detox. In a perfect world, a handful of supplements would effectively treat everything that ails us. Alas, the human body is a highly complex system and as such, requires many highly specific chemicals and nutrients, particularly once this remarkable machine has broken down. Much like a mirage, conventional medicine strives to find that “one size fits all” healing tonic that we all hope to see one day, yet realize is as impossible as it is impractical. Conversely, many alternative practitioners believe that every single piece of the puzzle must be fully addressed before one might reasonably expect health and recovery. Addressing the root cause of prevailing health issues, the body has a remarkable capacity for healing itself. And, though treating every single component may be ideal, in crafting a treatment program based on each person’s health background and genetic foundation as well as some of the similarities faced in chronic disease, one has an opportunity to streamline a highly individualized and successful regimen. Please be aware that despite its’ comprehensive appearance, this framework includes the bare minimum of basic supports. There are many more supplements that are highly recommended, and which are often based on the #genetic and biochemical testing as well as your overall health issues. Consider adding them in your regimen, if even in smaller doses. For instance, if there are significant issues with immunity then it is important to have some immune supports on board. 
 
 C.) Organ support: This is critical for several reasons; first & foremost, most chronically ill children and adults have less than optimal organ function and the liver, kidneys, pancreas, and adrenals are most challenged. Since detox requires ideal organ activity for filtering wastes and toxins, it is vital to have this support on board. Though the RNAs are especially advantageous, there are also less expensive options available below under practical supports.     In providing organ support, most will experience some milder detox symptoms. This is due to the fact that normally, those with chronic disease are not able to process and filter toxins, chemicals, and wastes optimally and the extra support allows for more efficient house cleaning. With this in mind, it is wise to start out with a sprinkle and gradually increase the dose over several weeks’ time. Ideal organ support may vary depending on nervous system dominance: • #Liver • #Kidney 
• #Pancreas 
• #Adrenal (this will depend on the nervous system type) 
Step TWO: Win the war with the gut A). Address Gut Issues: See for future consideration, depending on genetic testing This especially relates to the #SHMT & #ACAT defects, as these are priority mutations. However, the overwhelming majority of those plagued with chronic illness typically have several defects leading to gut problems. For many, these are the most important mutations to target since bacteria release ammonia and other wastes. The more ammonia your gut bugs make, the more waste you will have in the entire system, especially for those with the #CBS and/or #NOS defects. Nevertheless, genetic variations aside, the ensuing inflammation and #leakygut issues often lead to autoimmune and neurological activation, causing widespread complications. 
 
For those who have used birth control pills, #hormone replacement, steroids (prednisone/hydrocortisone), #antibiotics , and/or #antacid medications, the gut environment is often rife with harmful bacteria, #yeast OR #fungus and #parasites due to the hormonal imbalances and collateral damage instigated by such ubiquitous regimens. Furthermore, if you cannot absorb the necessary vitamins, minerals, and amino acids, you lack the fuel required for every other body system, particularly those that have high requirements such as the brain, heart, bone marrow and nerves. Add in the surfeit of processed starchy carbohydrates, sugars, saturated fats and calorie rich nutrient devoid diets most consume and you have a recipe for disaster. For anyone troubled with irritable bowel syndrome, inflammatory bowel disease, chronic constipation, diarrhea, bloating, belching, acid reflux, nausea, abdominal pain, and/or “sensitive” stomachs, it is almost certain that one or more of the following defects are present: #BHMT , #AHCY , #SHMT , #ACAT , and/or the #MTHFR #A1298C. However, #ACAT support should always come first with focus on the #SHMT as a close second. If these defects are not present, you are fortunate although mutations notwithstanding, gut support is almost universally central for the road to recovery, regardless of the disease or disorder. Order for treating health issues & defects: Evaluating the nervous system’s style or “dominance” is a key factor in the initial process. This will allow for a more targeted regimen, based on your individual needs. 1. Layering in a foundation of very basic supplements & support: general minerals, vitamin B’s & B12, #DigestiveEnzymes , #probiotics , #antioxidants , essential fatty acids, etc. 2. #Gut Health is critical. Since most chronically ill adults & children have at least 1-2 (if not 3-4 ) enzyme defects that affect the gut and digestion, the gut is always a factor. Gut bugs tend to harbor metals and many of them off gas ammonia and hydrogen sulfide, a poisonous sulfur byproduct. You can repeatedly clean up the gut yet if you have not addressed the underlying genetic contributions (SHMT, ACAT, MTHFR A1298C, #VDR Fok, AHCY, & BHMT) it will almost always resurface. 3. SHMT defect (Steals everything away from the system & causes gut issues as well as poor healing/recovery). 4.ACAT defect ( #Oxalates, #cholesterol, #mitochondrial issues, & severe gut #dysbiosis ) 5. #CBS/NOS defects (drains everything through the #transsulfuration pathway = liver, kidney, & #urea cycle dysfunction). Initially, targeting the gut bacteria is often more essential than fully addressing a CBS up- regulation. Many individuals have ammonia and sulfide producing bacteria within the gut and this noxious waste requires an escape route. Still, the CBS/NOS combination is often a significant issue and is important to address early on. 6. #MTHFR A1298C & MTHFR C677T: The A1298C is the more critical defect in #autism and other neurological disorders whereas the MTHFR 3 & #C677T (& ACE/NOS) are paramount for treating vascular diseases, such as heart disease, strokes, and clotting disorders. The MTHFR A1298C caps are critical for liver, gut, & BH4 support. Please consider that SAMe is only recommended for those who do not have the COMT +/+, although very low doses may be tolerated. 7. BHMT, also known as the “Shortcut” through the system. You need to have the short cut working prior to most other defects, particularly the MTR/MTRR defects, also known as the “Long Way Home.” Many have noted that #ADHD symptoms intensify with this defect as well as opening up this region, until the #MTR #MTRR is at least partially addressed. 8. MTR/MTRR or Long Route, which is essential for getting around the #methylation pathway as it converts #homocysteine into the critical methyl group known as #methionine . 9. Other Defects: Many others may need some management yet do not require as intensive focus. Pending the health issues and overall risks, enzymes such as the MTHFR’s, #COMT , NOS, ACE, #MAOA and VDR Taq & Fok often require some support since they contribute to heart, neurological & gut issues as well as mood swings, volatility, and increased stress with cortisol depletion. To learn more, read: Dr. Nancy Mullan & Amy Yasko PhD: How bacterial Imbalances May predispose to Seizure Disorder 
 
Dr. Nancy Mullan MD & Amy Yasko PhD: Gastrointestinal disorders and Neurotransmitter imbalances The proper use of probiotics: They must be rotated every 2-3 weeks for best outcomes. For those who are more sensitive, it is important to consider starting with smaller doses to avoid a significant die off reaction.  Key beneficial organisms: #Bifidobacteria #Acidophilus #Plantarum http://resqua.com/702188759/i-have-just-received-my-23andme-gene-variance-report-so-i-have-my-gene-mutations-what-should-i-do

STEP ONE: Layering in The Foundation
Knowing your Nervous system #dominance is an integral part in establishing the treatment process.
A). Remove or limit triggers:
Processed foods contain excitotoxins, dyes, and #toxic preservatives. It is also crucial to remove obvious food #allergies . Please see Resqua pages on #excitotoxins for more information. This is simply defined and discussed in detail. 



B). Begin general support:
Provide a good foundation for your nervous system type and begin nutritional support. Though life threatening reactions would be extremely rare (and to my knowledge, unheard of), moving too quickly can result in more intense symptoms of detox. In a perfect world, a handful of supplements would effectively treat everything that ails us. Alas, the human body is a highly complex system and as such, requires many highly specific chemicals and nutrients, particularly once this remarkable machine has broken down. Much like a mirage, conventional medicine strives to find that “one size fits all” healing tonic that we all hope to see one day, yet realize is as impossible as it is impractical.

Conversely, many alternative practitioners believe that every single piece of the puzzle must be fully addressed before one might reasonably expect health and recovery. Addressing the root cause of prevailing health issues, the body has a remarkable capacity for healing itself. And, though treating every single component may be ideal, in crafting a treatment program based on each person’s health background and genetic foundation as well as some of the similarities faced in chronic disease, one has an opportunity to streamline a highly individualized and successful regimen. Please be aware that despite its’ comprehensive appearance, this framework includes the bare minimum of basic supports.

There are many more supplements that are highly recommended, and which are often based on the #genetic and biochemical testing as well as your overall health issues. Consider adding them in your regimen, if even in smaller doses. For instance, if there are significant issues with immunity then it is important to have some immune supports on board. 
 


C.) Organ support:
This is critical for several reasons; first & foremost, most chronically ill children and adults have less than optimal organ function and the liver, kidneys, pancreas, and adrenals are most challenged. Since detox requires ideal organ activity for filtering wastes and toxins, it is vital to have this support on board. Though the RNAs are especially advantageous, there are also less expensive options available below under practical supports.    

In providing organ support, most will experience some milder detox symptoms. This is due to the fact that normally, those with chronic disease are not able to process and filter toxins, chemicals, and wastes optimally and the extra support allows for more efficient house cleaning. With this in mind, it is wise to start out with a sprinkle and gradually increase the dose over several weeks’ time.

Ideal organ support may vary depending on nervous system dominance:
#Liver
#Kidney

• #Pancreas

• #Adrenal (this will depend on the nervous system type)




Step TWO: Win the war with the gut
A). Address Gut Issues:
See for future consideration, depending on genetic testing This especially relates to the #SHMT & #ACAT defects, as these are priority mutations. However, the overwhelming majority of those plagued with chronic illness typically have several defects leading to gut problems. For many, these are the most important mutations to target since bacteria release ammonia and other wastes. The more ammonia your gut bugs make, the more waste you will have in the entire system, especially for those with the #CBS and/or #NOS defects. Nevertheless, genetic variations aside, the ensuing inflammation and #leakygut issues often lead to autoimmune and neurological activation, causing widespread complications. 


For those who have used birth control pills, #hormone replacement, steroids (prednisone/hydrocortisone), #antibiotics , and/or #antacid medications, the gut environment is often rife with harmful bacteria, #yeast OR #fungus and #parasites due to the hormonal imbalances and collateral damage instigated by such ubiquitous regimens.

Furthermore, if you cannot absorb the necessary vitamins, minerals, and amino acids, you lack the fuel required for every other body system, particularly those that have high requirements such as the brain, heart, bone marrow and nerves. Add in the surfeit of processed starchy carbohydrates, sugars, saturated fats and calorie rich nutrient devoid diets most consume and you have a recipe for disaster. For anyone troubled with irritable bowel syndrome, inflammatory bowel disease, chronic constipation, diarrhea, bloating, belching, acid reflux, nausea, abdominal pain, and/or “sensitive” stomachs, it is almost certain that one or more of the following defects are present: #BHMT , #AHCY , #SHMT , #ACAT , and/or the #MTHFR #A1298C.

However, #ACAT support should always come first with focus on the #SHMT as a close second. If these defects are not present, you are fortunate although mutations notwithstanding, gut support is almost universally central for the road to recovery, regardless of the disease or disorder.

Order for treating health issues & defects:
Evaluating the nervous system’s style or “dominance” is a key factor in the initial process. This will allow for a more targeted regimen, based on your individual needs.

1. Layering in a foundation of very basic supplements & support: general minerals, vitamin B’s & B12, #DigestiveEnzymes , #probiotics , #antioxidants , essential fatty acids, etc.

2. #Gut Health is critical. Since most chronically ill adults & children have at least 1-2 (if not 3-4 ) enzyme defects that affect the gut and digestion, the gut is always a factor. Gut bugs tend to harbor metals and many of them off gas ammonia and hydrogen sulfide, a poisonous sulfur byproduct. You can repeatedly clean up the gut yet if you have not addressed the underlying genetic contributions (SHMT, ACAT, MTHFR A1298C, #VDR Fok, AHCY, & BHMT) it will almost always resurface.

3. SHMT defect (Steals everything away from the system & causes gut issues as well as poor healing/recovery).

4.ACAT defect ( #Oxalates, #cholesterol, #mitochondrial issues, & severe gut #dysbiosis )

5. #CBS/NOS defects (drains everything through the #transsulfuration pathway = liver, kidney, & #urea cycle dysfunction).
Initially, targeting the gut bacteria is often more essential than fully addressing a CBS up- regulation. Many individuals have ammonia and sulfide producing bacteria within the gut and this noxious waste requires an escape route. Still, the CBS/NOS combination is often a significant issue and is important to address early on.

6. #MTHFR A1298C & MTHFR C677T: The A1298C is the more critical defect in #autism and other neurological disorders whereas the MTHFR 3 & #C677T (& ACE/NOS) are paramount for treating vascular diseases, such as heart disease, strokes, and clotting disorders. The MTHFR A1298C caps are critical for liver, gut, & BH4 support. Please consider that SAMe is only recommended for those who do not have the COMT +/+, although very low doses may be tolerated.

7. BHMT, also known as the “Shortcut” through the system. You need to have the short cut working prior to most other defects, particularly the MTR/MTRR defects, also known as the “Long Way Home.” Many have noted that #ADHD symptoms intensify with this defect as well as opening up this region, until the #MTR #MTRR is at least partially addressed.

8. MTR/MTRR or Long Route, which is essential for getting around the #methylation pathway as it converts #homocysteine into the critical methyl group known as #methionine .

9. Other Defects: Many others may need some management yet do not require as intensive focus. Pending the health issues and overall risks, enzymes such as the MTHFR’s, #COMT , NOS, ACE, #MAOA and VDR Taq & Fok often require some support since they contribute to heart, neurological & gut issues as well as mood swings, volatility, and increased stress with cortisol depletion.

To learn more, read:
Dr. Nancy Mullan & Amy Yasko PhD: How bacterial Imbalances May predispose to Seizure Disorder 


Dr. Nancy Mullan MD & Amy Yasko PhD: Gastrointestinal disorders and Neurotransmitter imbalances
The proper use of probiotics: They must be rotated every 2-3 weeks for best outcomes. For those who are more sensitive, it is important to consider starting with smaller doses to avoid a significant die off reaction.

Key beneficial organisms:
#Bifidobacteria #Acidophilus #Plantarum

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