Summary of analogies used in methylation community: CEOs: Directs each corporation in organized steps
Supervisors: Enzymes such as MTHFRs, COMT, SHMT, and BHMT
Enzymes are proteins that are produced by living cells and regulate the body’s process to breakdown products, such as ammonia.
Employees: Chemicals, proteins, DNA, etc.
Work tags: Methyl groups (Homocysteine, SAM, Methionine) The Chain Gang: Homocysteine (HCY)
Synopsis of the Cycles
1). Power Plant = Citric Acid Cycle =
Formerly known as the Kreb’s cycle) Recognized as the mitochondrial or energy cycle
2). Garbage Dump (& Recycling) =
The urea cycle, ammonia cleanup & nitric oxide production (heart/blood vessel protection)
3). Better Health 4 Life Corp (BH4) = Communications “AT&T” & toxic waste cleanup Neurotalkers: Dopamine, Serotonin, & Norepi
4). SAM’s Corp. = Methionine Cycle =
The major producer of methyl donors and the passageway to the garbage dump (NOS) & liver via the CBS enzyme
5). Farmer Folate = Folate Cycle =
Homegrown” RNA & DNA, methyl groups and Homocysteine (HCY) regulation
The Meaning of Methylation
Methylation is truly a multi-tasking marvel that allows us to be “healthy and human.” Though this highly intricate process occurs within each cell as well as in the fluid supplying the brain and within the liver, it is responsible for the most vital undertakings throughout body chemistry. Methylation determines who we are, what we look like, and how we behave and it is central to our physical, emotional, and mental wellbeing. Without methylation, we could not survive; hence, it is the perfect pathway to focus on for understanding autoimmune and neurological diseases such as multiple sclerosis, seizure disorders, dementia, Lou Gehrig’s, chronic fatigue syndrome, lupus, depression, anxiety, and autism spectrum disorders.
What are methyl groups & how do they work?
Lets get the mind-numbing part out of the way first so we can discuss this in everyday terms. Methylation begins with a methyl group, which is stuck together with a carbon and three hydrogen atoms, although we will simply call these tags. These tags are like passes, or work orders, so that as “methylation” begins within each department, a work tag is passed onto another worker, or molecule. Although we go about our lives completely unaware of this elaborate process, methylation is responsible for making, maintaining, and repairing DNA,
which is your genetic code. You don’t need to fully understand genetic code in order to understand the implications here. If you cannot create or mend what makes you distinctively you, there are going to be serious problems. This is analogous to crafting a car without bolts, wiring, or cables—while it might look like a car, be prepared for some surprises when you attempt to drive it off the lot. Just as a highly skilled assembly line manufactures quality automobiles, the methylation community regulates the switching on and off of the genetic codes, thereby creating a high functioning human being. Since many of us have several less desirable genetic variations, this is essential for regulating gene expression, particularly cancer causing genes. This system also silences virus and supports immunity while regulating sulfur metabolism, a major contributor in the body’s detoxification, or filtering, pathway. When functioning optimally, methylation assures that the less desired genes are switched off while the preferred genes are switched on so that the system runs successfully. This is known as gene expression and cancer and birth defects are an excellent example of where this process has gone awry.
What are those cycles?
The methylation community has specific areas, known as cycles. The cycles, designed much like well-run fortune 500 Companies, have very specific duties. Each one has a chief operating officer (CEO), that determines its’ purpose, as well as supervisors, employees, and work orders (tags), known as methyl groups. The CEO establishes protocols and delegates various tasks to each supervisor, who is really just the cycle’s enzyme (Big Motherflipper, COMT, or BHMT). The supervisor then meets with the employees to hand out assignments, via work tags (methyl groups). The employees are often chemicals, proteins, or DNA that need the work tags to function effectively. Still, once the supervisor gives each employee an assignment and hands out the work passes; the jobs should be carried out (methylation). And, just as each corporation has a time-honored system, the methylation pathway has stages for beginning, maintaining, and completing the job. Of course, this also means that problems can arise at any given juncture. Nevertheless, don’t let the chemistry names and processes intimidate you. As you review the “simplified” diagrams, remind yourself that every cycle is merely a factory that operates for a specific purpose. The CEO meets with the supervisors, who in turn, meet with the employees to pass on designated work tags (methylation). Though this is a simplified illustration of the methylation process, it includes the major elements of this biochemical pathway.
The above information is based upon ‘The Yasko Hypothesis of Neurodegenerative and Autoimmune Disease’ as well as the extensive research conducted by Dr. Jill James & colleagues on the Methylation Pathway (Folate & Methionine Cycles). I have also included information regarding nervous system dominance by Drs. Pottenger, Kelley, & Gonzalez.
#CitricAcid Cycle #UreaCycle #Methionine #Homocysteine #ammonia #Methylgroups #MTHFR #COMT #SHMT #BHMT
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