Resqua

What is the process of Methylation?

6 years, 8 months ago

Methylation is a key biochemical process that is essential for the proper function of almost all of your body’s systems. It occurs billions of times every second; it helps repair your DNA on a daily basis; it controls homocysteine (an unhealthy compound that can damage blood vessels); it helps recycle molecules needed for detoxification; and it helps maintain mood and keep inflammation in check.

To keep methylation running smoothly you need optimal levels of B vitamins. Without enough B vitamins methylation breaks down, and the results can be catastrophic. In these cases we see more birth defects like spina ... ..more

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What is Methylation?

6 years, 8 months ago

Methylation
The methylation pathway can be likened to the body’s chief housekeeping and maintenance systems. It is responsible for many of the most complex and vital undertakings throughout the body, occurring each time the body takes one substance and turns it into another. This chemical exchange occurs between enzymes, amino acids, proteins, and other molecules in order to maintain cell function. Methylation regulates gene expression, allowing beneficial genes to function while keeping less desirable genes at bay. It also provides the backbone for the immune system, DNA, RNA, cellular repair, detoxification, hormone regulation, and communication between the cells and ... ..more

YouTube

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDYx9oIDA Methylation Question: What is Methylation? Answer: Methylation The methylation pathway can be likened to the body’s chief housekeeping and maintenance systems. It is responsible for many of the most complex and vital undertakings throughout the body, occurring each time the body takes one substance and turns it into another. This chemical exchange occurs between enzymes, amino acids, proteins, and other molecules in order to maintain cell function. Methylation regulates gene expression, allowing beneficial genes to function while keeping less desirable genes at bay. It also provides the backbone for the immune system, DNA, RNA, cellular repair, detoxification, hormone regulation, and communication between the cells and organ systems by way of neurotransmitters. This intricate process occurs in the liver and in each cell as well as in the fluid supplying the brain and spinal cord. It is a rare find indeed; a multi-tasking marvel. Methylation helps determine who we are, what we look like, and how we behave yet even more importantly, it is central to our physical, emotional, and mental wellbeing. Since methylation appears to be one of the major influences for each person’s response to medications, vaccines, and supplements, it has been under intense scrutiny with pharmaceutical companies and scientists throughout the world. In fact, this reaction is critical for survival, making it an indispensible sequence to focus on for grasping autoimmune and neurological diseases such as multiple sclerosis, colitis, diabetes, lupus, chronic fatigue syndrome, depression, anxiety, dementia and autism spectrum disorders. The Science Behind Methylation Methylation begins with a methyl group, which is held together with a carbon and three hydrogen atoms (water has two), and for the sake of simplicity, we will simply refer to these groups as tags. The tags act as work orders so that as “methylation” begins in any cycle, the department head passes on a work order to the employees. Once the employees, who in this case may be proteins, amino acids, or enzymes, receive their work orders, they have been methylated. Though we go on about our lives completely unaware of this elaborate process, methylation is responsible for making, maintaining, and repairing DNA, your genetic code. Unquestionably, if you cannot create and mend what makes you so unique, there are going to be serious complications. Under optimal conditions, methylation restricts the activity of less beneficial genes while allowing the most advantageous to switch on so that the system runs more successfully. In fact, the methylation pathway serves as a fundamental mechanism for lifelong health and wellbeing by suppressing the appearance of viral or cancer- provoking genes. While this reaction, known as gene expression, has potential for great success, cancer and birth defects are excellent examples of when this process has gone awry. DNA is Not Destiny: Discover Magazine http://discovermagazine.com/2006/nov/cover An Excellent 7 minute video for lay people on epigenetics & methylation http://www.youtube.com/watch?v=Fj4d-9Jgl6g&NR=1 Another Excellent 7 minute video for lay people on epigenetics & methylation http://www.youtube.com/watch?v=Xjq5eEslJhw&NR=1 #Methylation #Epigenetics #Genes #23andMe #DNA #sclerosis #colitis #diabetes #lupus #chronicfatigue #depression #anxiety #dementia and #autism spectrum disorders #RNA http://resqua.com/702188759/what-is-methylation

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What are the factors that affect methylation?

6 years, 8 months ago

8 Factors that Affect Your Methylation Process

--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine

--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgID2qJMKDA Methylation Question: What are the factors that affect methylation? Answer: 8 Factors that Affect Your Methylation Process --Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine --Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat, coffee, and alcohol. Irradiation of food depletes nutrients, so foods treated this way may be lower in B vitamins, too --Smoking – The carbon monoxide from cigarette smoke inactivates vitamin B6 --Malabsorption - Conditions like digestive diseases, food allergies, and even aging can reduce absorption of nutrients --Decreased stomach acid – Aging and other conditions can reduce stomach acid — and therefore absorption of vitamin B12 --Medications – Drugs like acid blockers, methotrexate (for cancer and arthritis and other autoimmune diseases), oral contraceptives, HCTZ (for high blood pressure), and Dilantin (for seizures) can all affect levels of B vitamins --Other conditions – These include hypothyroidism, kidney failure or having only one kidney, cancer, and pregnancy --Toxic exposures – Some toxins can interfere with vitamin production Watch out for these factors and you will go a long way toward protecting your methylation. Measuring Your Own Methylation Process To find out if your methylation process is optimal, ask your doctor for the following tests: Complete blood count – Large red blood cells or anemia can be a sign of poor methylation. Red blood cells with a mean corpuscular volume (MCV) greater than 95 can signal a methylation problem Homocysteine – This is one of the most important tests you can ask for. The normal level is less than 13, but the ideal level is likely between 6 and 8 Serum or urinary methylmalonic acid – This is a more specific test for vitamin B12 insufficiency. Your levels may be elevated even if you have a normal serum vitamin B12 or homocysteine level Specific urinary amino acids – These can be used to look for unusual metabolism disorders involving vitamins B6 or B12 or folate, which may not show up just by checking methylmalonic acid or homocysteine http://resqua.com/702188759/what-are-the-factors-that-affect-methylation

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Is impaired methylation the cause of ME or Chronic Fatigue Syndrome CFS ? How can I recover from Chronic Fatigue Syndrome CFS ?

6 years, 11 months ago

Understanding #chronic #fatigue Syndrome #CFS

I left the Mayo Clinic in 2007 a little relieved, a little angry and very poor. Now, I know exactly why I was angry after watching the series of videos below (more about that later). Unfortunately, my anger at being diagnosed with Chronic Fatigue prevented me from doing my own research – I was fed up and I just retreated to my cave for five years to try to heal with diet and lifestyle improvements. That was a big mistake because it appears that a number of researchers have figured out chronic fatigue. If you’ve ... ..more

Vimeo

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICU55MKDA Methylation Question: Is impaired methylation the cause of ME or Chronic Fatigue Syndrome CFS ? How can I recover from Chronic Fatigue Syndrome CFS ? Answer: Understanding #chronic #fatigue Syndrome #CFS I left the Mayo Clinic in 2007 a little relieved, a little angry and very poor. Now, I know exactly why I was angry after watching the series of videos below (more about that later). Unfortunately, my anger at being diagnosed with Chronic Fatigue prevented me from doing my own research – I was fed up and I just retreated to my cave for five years to try to heal with diet and lifestyle improvements. That was a big mistake because it appears that a number of researchers have figured out chronic fatigue. If you’ve got fatigue, I can’t recommend the late Richard van Konynenburg’s video enough. Find some quiet time and watch all 3 parts. I’m already a believer because I’m in the process of titrating up folate and methyl #B12 (reached 2.4 mg folate and 3 mg B12 yesterday). The improvement I’m feeling has had me thinking about bypassing the titration and just chewing up a whole bottle of the stuff! By no means am I cured, but am feeling tantalizing improvements. In Part I, I got a good appreciation for the extent of chronic fatigue syndrome - it’s worldwide and sufferers number in the millions. Richard clearly understands what it’s like to have CFS even though he never experienced it. The biochemistry is the main event in Part I and it goes very deep: http://vimeo.com/36511892 You’ll see there is a lot of overlap with my last post on understanding methylation. But, Dr. Lynch’s presentation is very different from Richard van Konynenburg’s and you want to see them both. In Part II, you’ll start to hear about treatment protocols for CFS http://vimeo.com/36727242 In Part III, you’ll hear about the clinical study and specific case reviews… it’s fascinating: http://vimeo.com/30129653 Here are Richard’s comments about the Mayo Clinic (starts at about 57 minutes): "I guess this is being recorded so I have to be careful what I say. I’ll just tell you that over the past 15 years I’ve been on the patient Internet groups for chronic fatigue syndrome and I’ve heard from a lot of people some of whom have gone to Mayo and the report pretty much from every one, is that Mayo runs a whole lot of wonderful tests, they send you to various specialists and they all say “It’s normal and what you need to do is see our psychiatrist” and they send them over there and prescribe them an antidepressant. Okay — and that’s what Mayo does for chronic fatigue syndrome. And I think that’s still true." Well, that is precisely what they did to me in 2007 — years and years after Andy Cutler had published AI, and who knows how long after methylation treatments were being pioneered by Dr. Yasko, Konynenburg and others. I’ll never forget the psychiatrist using his leading questions on me, pushing me to admit that my physical problems might derive from depression. I’ll never forget the look of derision when I told him that anyone with my physical limitations would feel some depression, especially at the thought that I might be dying considering the downward spiral I was in. Check out the crap recommendations about cognitive behavioral therapy still on Wikipedia’s CFS page. They’re on the same level with Mayo Clinic. So exactly what improvements am I feeling? Because I’ve also radically changed my diet while chelating and taking lots of supplements including iodine, I can’t pin the improvements precisely on B-12 and folate but, I have felt little bursts of additional energy on the days I’ve increased my dosage. Yesterday, for example, I had a two-hour meeting after lunch and never felt like I was suffocating or jittery from energy debt. I never lost my train of thought irretrievably. I kind of stayed cool and collected mentally. Then, because I ran into a traffic jam on the way home ended up having to pick up the kids at school. So, I was out for three hours in situations that I consider high energy drains. Typically, I can always muscle through those on adrenaline fumes. When I got home I lay down for a nap and I actually drifted to sleep. When I’m running on adrenaline, I’m unable to rest and recover. so it seems something different happened yesterday. Later in the early evening, I was outside with neighbors and family and played a little bit of backyard soccer and still felt okay afterwards. had no trouble relaxing or falling asleep at bedtime. In other words, I had an active day and stayed out of the red zone. That’s kind of remarkable. On the other hand, had the meeting been three hours long I don’t know what would’ve happened. It’s still too early for me to say what’s going on! What I know for certain is I’m angry, or let’s say ‘trying hard not to be angry’ at the Mayo Clinic doctors and all the others I’ve seen over the last 12 years. At the same time, I’m terribly excited about helping my wife heal with the new knowledge I’ve absorbed this week. http://howirecovered.com/understanding-chronic-fatigue/ http://resqua.com/702188759/is-impaired-methylation-the-cause-of-me-or-chronic-fatigue-syndrome-cfs-how-can-i-recover-from-c

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What is Homocysteine ?

6 years, 11 months ago

#Homocysteine is a toxic waste by-product of protein and amino acid metabolism, and #methylation in the body is going on constantly, converting this damaging homocysteine into the #antioxidant #glutathione.
Methylation also converts homocysteine into an important biochemical called #SAMe , a vital methyl donor for the production of the all important neurotransmitters dopamine, serotonin and their derivatives. This is how the body makes good use of this toxic element.

Keeping homocysteine at a healthy, low level is extremely important for keeping our risk of heart disease, stroke and Alzheimer's disease as low as possible. High levels of homocysteine, if left ... ..more

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How does Methylation influence mood ?

6 years, 11 months ago

It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.

Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICk7pIKDA Methylation Question: How does Methylation influence mood ? Answer: It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered. Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is producing too many neurotransmitters, and an under methylator is not producing enough, this is because firstly, it falls in line with majority thinking, and secondly, it makes more chemical sense. There are #genetic factors that can cause some people to be slow methylators, and others to be fast methylators. The really exciting thing about methylation is that you can manipulate your methylation processes to create dramatic, positive #mood changes within yourself. #Homocysteine Homocysteine is a toxic waste by-product of protein and amino acid metabolism, and methylation in the body is going on constantly, converting this damaging homocysteine into the antioxidant glutathione. Methylation also converts homocysteine into an important biochemical called SAMe, a vital methyl donor for the production of the all important neurotransmitters dopamine, serotonin and their derivatives. This is how the body makes good use of this toxic element. Keeping homocysteine at a healthy, low level is extremely important for keeping our risk of heart disease, stroke and Alzheimer's disease as low as possible. High levels of homocysteine, if left unchecked, can cause stroke, brain inflammation, vascular disease, erectile dysfunction, liver and kidney disease, thyroid problems, Alzheimer's disease, dementia and depression. Vitamin deficiencies most associated with high homocysteine levels are B6, B12 and folic acid. The excitatory neurotransmitters are; Dopamine, histamine, norepinephrine, epinephrine, noradrenaline, glutamate, acetylcholine. The inhibitory neurotransmitters are; #GABA , #serotonin, #acetylcholine . Note: A few reports have stated that #dopamine , #serotonin and acetylcholine, can be #excitatory or inhibitory depending on which receptor site in the nerve sinapse they bind to. From my own experience, I have only found this to be accurate with #acetylcholine . High dopamine has at times resulted in an overdriven mood, agitation and ensuing mental #exhaustion etc, bearing in mind it's the precursor to #noradrenaline ( #allergies etc), whereas high serotonin has resulted in poor memory, drowsiness, #apathy , poor motivation and concentration. It may well be that serotonin becomes excitatory only in the presence of adequate #dopamine , which from my experience seems to be the case. You can see that having too many inhibitory #neurotransmitters working together could result in a flat, lifeless mood, especially if noradrenaline etc is low, then couple this with low blood sugar, a #CFS (chronic fatigue syndrome) or #FM (fibromyalgia) episode and you have another mood disaster. There doesn't seem to be a universal agreement on which nutrients increase methylation and which ones decrease it. One statement will say folic acid, #B6, #B12 , #TMG , #SAMe , #zinc , and another will maybe leave zinc out of the mixture and put choline, #B3 or #5-HTP in! With the exception of B3, I think that they all increase methylation, but different aspects of it, which is why taking all of these ingredients never really works well for most people with methylation problems. As an example, if you had excessive levels of dopamine and noradrenaline, and very low levels of serotonin, you would be overdriven with high agitation and anxiety. If you then supplemented with SAM-e, you would raise your serotonin but then push your dopamine etc even higher, because SAM-e raises both serotonin and dopamine, so there would be either no change, or another mood disaster. A shotgun approach to influence complex, chemical reactions is doomed to fail because a fault with methylation will be different from one person to another. As you can see, simply trying to raise or lower your methylation could easily end in disaster. Taking large doses of any of the suggested supplements to correct methylation problems will not always work well, simply because there seems to be a precise level to attain that is unique to each person. For instance, with higher than optimum B6 and magnesium, more homocysteine is taken away from methylation and converted to cysteine, which can interfere with insulin activity, and with lower than optimum levels of B6 and magnesium, the methylation target may not be met. Balance is everything. Allergies, food intolerances and blood sugar status will all have a detrimental effect on methylation efficiency, so these must be addressed before methylation can be tuned. http://resqua.com/702188759/how-does-methylation-influence-mood

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What is the Tetrahydrobiopterin BH4 Cycle ?

6 years, 11 months ago

A chemical made in the BH4 cycle, which is used to produce dopamine and serotonin, neurotransmitters strategic in regulating mood, sleep, attention and focus, reward seeking behavior, addiction, and sense of wellbeing. BH4 is also critical in the urea cycle (waste facility) for cleaning up ammonia and making nitric oxide. A shortage of this important chemical has widespread repercussions.

Tetrahydrobiopterin BH4 Cycle produces the BH4 used for making neuro-talkers (dopamine, epinephrine, nor-epi, serotonin, & melatonin). It cleans up toxic ammonia in The Waste Cycle & makes Nitric oxide to protect the heart & brain.

Though controversy exists regarding this cycle’s function, Dr. Yasko’s theory indicates that The Big Motherflipper (MTHFR A1298C) may drive this cycle in the reverse direction and several independent studies support this finding. This leads to a chemical exchange among BH2 to BH4, a multi-purpose product that is used in both the Waste Facility (urea cycle) and BH4 Industry. Within the Better Health 4 Life Industry, BH4 produces chemicals known as neurotransmitters, or neurotalkers (NTs), including dopamine, serotonin, melatonin, norepinephrine, and epinephrine. NTs are central for the communication between nerves and cells as well as stabilizing the crisis response, mood, and sleep cycles. Chronically low BH4 levels increase the risk for ADD/ADHD, Bipolar Disorder, OCD, insomnia, depression, anxiety, and many other quality of life issues. Think of this company as AT&T with a philanthropic twist since it donates BH4 to the Waste Facility for environmental clean up as well as supporting the community in health & wellbeing.

The Waste Facility uses BH4 to clean up toxic ammonia and generates nitric oxide, an element that keeps blood vessels open and free of plaque. Yet if BH4 is scarce, it cannot clean up waste or deliver vital nutrients to the Power Plant (fumarate) so that noxious chemicals back up into SAM’s Corporation. Given the fact that it takes 2 grains of BH4 to clean up 1 granule of ammonia, as well as 2 of BH4 to create just 1 bit of nitric oxide, its easy to see how problems might arise. This underscores the BH4 Industry’s role throughout the community since unlike an actual factory; it isn’t permitted to shut down for repairs or maintenance.

While there are many factors that may impact this cycle, several are listed below:

1. A ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICYn7QJDA Methylation Question: What is the Tetrahydrobiopterin BH4 Cycle ? Answer: A chemical made in the BH4 cycle, which is used to produce dopamine and serotonin, neurotransmitters strategic in regulating mood, sleep, attention and focus, reward seeking behavior, addiction, and sense of wellbeing. BH4 is also critical in the urea cycle (waste facility) for cleaning up ammonia and making nitric oxide. A shortage of this important chemical has widespread repercussions. Tetrahydrobiopterin BH4 Cycle produces the BH4 used for making neuro-talkers (dopamine, epinephrine, nor-epi, serotonin, & melatonin). It cleans up toxic ammonia in The Waste Cycle & makes Nitric oxide to protect the heart & brain. Though controversy exists regarding this cycle’s function, Dr. Yasko’s theory indicates that The Big Motherflipper (MTHFR A1298C) may drive this cycle in the reverse direction and several independent studies support this finding. This leads to a chemical exchange among BH2 to BH4, a multi-purpose product that is used in both the Waste Facility (urea cycle) and BH4 Industry. Within the Better Health 4 Life Industry, BH4 produces chemicals known as neurotransmitters, or neurotalkers (NTs), including dopamine, serotonin, melatonin, norepinephrine, and epinephrine. NTs are central for the communication between nerves and cells as well as stabilizing the crisis response, mood, and sleep cycles. Chronically low BH4 levels increase the risk for ADD/ADHD, Bipolar Disorder, OCD, insomnia, depression, anxiety, and many other quality of life issues. Think of this company as AT&T with a philanthropic twist since it donates BH4 to the Waste Facility for environmental clean up as well as supporting the community in health & wellbeing. The Waste Facility uses BH4 to clean up toxic ammonia and generates nitric oxide, an element that keeps blood vessels open and free of plaque. Yet if BH4 is scarce, it cannot clean up waste or deliver vital nutrients to the Power Plant (fumarate) so that noxious chemicals back up into SAM’s Corporation. Given the fact that it takes 2 grains of BH4 to clean up 1 granule of ammonia, as well as 2 of BH4 to create just 1 bit of nitric oxide, its easy to see how problems might arise. This underscores the BH4 Industry’s role throughout the community since unlike an actual factory; it isn’t permitted to shut down for repairs or maintenance. While there are many factors that may impact this cycle, several are listed below: 1. A defect within the Big Motherflipper leads to lower BH4 levels. 2. Chronic bacterial infections create more ammonia, cleave to aluminum, & use up tryptophan, a serotonin precursor; leading to more BH4 depletion. 3. Though high protein diets create more ammonia, for those with Big Motherflipper defect alone, it isn’t critical. In concert with other defects (BHMT, CBS, NOS), this diet becomes more of a problem. 4. Weaknesses within the BHMT, CBS, and/or NOS imply that critical levels of BH4 are being used up, leading to greater system malfunction. 5. Aluminum & other toxins greatly impact the Big Motherflipper’s output, thus reducing BH4 supplies. 6. The janitors below this cycle (MAO/COMT) work too efficiently and clean up dwindling supplies of NTs. 7. Although not depicted on the diagram, there may also be a defect within the DHPR enzyme, which converts BH2 to BH4 via the Big Motherflipper. Fortunately, this Industry has contingency plans in place for keeping communication open in times of crisis. Should the plant suffer a major decline in BH4 production, reserves may be activated in order to maintain as many byproducts of BH4 as possible. For instance, you may have inherited a stopgap that allows dopamine & norepinephrine conservation (COMT) or another for serotonin (MAO A). The COMT, in conjunction with the VDR, influences the overall need for work tags. As with many things, such options can be highly beneficial or tricky, depending on the mixture of problems. In its’ quest for survival of the fittest, the body’s immediate goal is preservation in the here & now, rather than later consequences. In the end, epigenetics increases the odds for survival, but with a price. Normally, the BH4 to ammonia ratio should be: 2 molecules of BH4 to clean up 1 molecule of ammonia = 0 waste, as it’s eliminated through the kidneys and liver. However, with a BH4 shortage, the ratio looks more like: 1 molecule of BH4 to clean up 1 molecule of ammonia = Peroxynitrate (PN) 0 molecules of BH4 to clean up 1 molecule of ammonia = Super Oxide (SO) To learn more Dr. Martin Pall’s Interview: Q& A regarding CFS/FM and this cycle http://www.chronicfatiguetreatments.com/wordpress/treatments/interview-with-dr-martin-pall/ Dr. Amy Yasko Discussion regarding BH4, NOS, & Microglial activation http://www.dramyyasko.com/resources/webisodes/bh4-nos-microglial-activation/ Dr. Nancy Mullan MD & Amy Yasko PhD: Methylation http://www.scribd.com/doc/63440767/Methionine-and-Methylation-Chicken-or-the-Egg Dr. Richard Van Konynenburg Methylation in CFS/ME http://vimeo.com/36511892 #BH4 #dopamine #epinephrine #norepinephrine #serotonin #melatonin #ammonia #NitricOxide http://resqua.com/702188759/what-is-the-tetrahydrobiopterin-bh4-cycle

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What is Ammonia ?

6 years, 11 months ago

#Ammonia is a product of protein digestion and the #urea cycle is required for the body to excrete ammonia. In patients with partial enzyme deficiencies, the first recognized clinical episode may be delayed for months or years. Early in life, infants with urea cycle disorders develop toxic levels of ammonia build-up in the blood.
#CBS #23andMe #health #MTHFR #Livewello
#Genes #Methylation #SNPs #gene ..more

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What is Super Oxide and Peroxynitrate ?

6 years, 11 months ago

These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle
( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgID47Z0KDA Methylation Question: What is Super Oxide and Peroxynitrate ? Answer: These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle ( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility, a lack of BH4 either leads to the free radical known as #peroxynitrate (PN) or the #oxidant that acts as a lethal weapon, super oxide ( #SO ). If there is only a mild #BH4 shortage, PN production begins whereas a severe deficiency leads to the manufacturing of SO. And so begins their violent rampage of murder and destruction while the healthy cells either flee the city or are crushed in the melee. It is important to consider that with continued and/or persistent exposures to harmful encounters and substances, you’ll find more criminals preying on the productive and healthier cells. There are many events and behaviors that contribute to toxic exposures, thereby markedly increasing your risks for developing chronic disease. Though there are hundreds of possibilities, below you will find the most common activities that increase free radicals: • Exercising outdoors on a high smog day • Eating fish (tuna) that is often laden with #mercury , #dioxin, and #PCBs • Drinking too much alcohol • Eating fast or fried foods • Smoking or second hand smoke • Using illicit drugs • Eating foods with pesticides & #toxic dyes, #preservatives & #phenols Regrettably, the processed #foods that most of us eat are bursting with glutamates ( #MSG / #aspartame ) and this causes substantial free radical damage. The chemicals and additives used in the food supply such as “natural flavors”, #bouillon , #hydrolyzed protein, #xanthum gum and #guar gum are all examples of hidden MSG. #Glutamates cause widespread #mitochondrial , nerve and brain cell damage by allowing free radicals to flourish. Sadly, this doesn’t even begin to account for the effect of pesticides, toxic preservatives, and artificial coloring. If you’ve ever wondered why you feel so poorly after a day of eating processed, fast foods or after festive night with too much wine or beer, you now know the culprits. To make matters worse, those with the #CBS and/or #NOS defects have even more damage. Needless to say, it pays to be mindful of these bad boys and to reduce your risks as much as possible. There are also many nutrients and supplements that support this process, thereby helping to offset the damage. Anything that enhances #BH4 levels or acts as a free radical scavenger or #antioxidant is often highly beneficial. To summarize the chief issues associated with free radical damage and oxidation: 1). Blood vessels won’t have nitric oxide (NO) for protection & may develop spasms/narrowing or plaques. 2). There will be a shortage of #dopamine and #serotonin production for communication throughout the brain. 3). Increased toxic waste activates untold damage throughout the entire system. 4). Two new bad guys emerge from the wreckage, the free radicals known as Peroxynitrate (PN) and Super Oxide (SO). http://resqua.com/702188759/what-is-super-oxide-and-peroxynitrate

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