VITAMIN D Receptor BSM Single Nucleotide Polymorphism [SNP] and AUTOIMMUNE DISEASE
PICTURE: Vitamin D Receptor BSM1 [A60890G]
Most doctors don't check for Vitamin D 1,25 because it’s half-life is so very short and the doctors were generally taught in medical school not to bother checking Vitamin D1,25 levels.
People with the Vitamin D Receptor mutations called VDR BSM end up readily converting their vitamin D to D1,25 and meanwhile their Total Vitamin D 25 appears to be low [because it is all getting converted to D 1,25, and their doctors aren’t checking their Vitamin D1,25 levels] And so, the doctor doesn’t realize that although their patient’s Total Vitamin D appears to be too low, in reality they have plenty of Vitamin D in the active form of Vitamin D 1,25.
VDR BSM +/+ is protective against cancer because it up-regulates the conversion of Vitamin D to the active form [Vitamin D 1,25], but when a person with the BSM mutation takes too much vitamin D it can become counterproductive and some have said that it actually could cause harm because it can lead to autoimmune diseases. If the person’s Vitamin D 1,25 is up but the other forms of Vitamin are low...then the VDR Bsm SNP may be causing the Vitamin D3 and D2 to be converted into D 1,25 quickly making the low D2 and D3 fool you and your doctor into thinking you need more Vitamin D, when in actuality you are really OK. #VitD
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