The methylation pathway can be likened to the body’s chief housekeeping and maintenance systems. It is responsible for many of the most complex and vital undertakings throughout the body, occurring each time the body takes one substance and turns it into another. This chemical exchange occurs between enzymes, amino acids, proteins, and other molecules in order to maintain cell function. Methylation regulates gene expression, allowing beneficial genes to function while keeping less desirable genes at bay. It also provides the backbone for the immune system, DNA, RNA, cellular repair, detoxification, hormone regulation, and communication between the cells and organ systems by way of neurotransmitters. This intricate process occurs in the liver and in each cell as well as in the fluid supplying the brain and spinal cord. It is a rare find indeed; a multi-tasking marvel.
Methylation helps determine who we are, what we look like, and how we behave yet even more importantly, it is central to our physical, emotional, and mental wellbeing. Since methylation appears to be one of the major influences for each person’s response to medications, vaccines, and supplements, it has been under intense scrutiny with pharmaceutical companies and scientists throughout the world. In fact, this reaction is critical for survival, making it an indispensible sequence to focus on for grasping autoimmune and neurological diseases such as multiple sclerosis, colitis, diabetes, lupus, chronic fatigue syndrome, depression, anxiety, dementia and autism spectrum disorders.
The Science Behind Methylation
Methylation begins with a methyl group, which is held together with a carbon and three hydrogen atoms (water has two), and for the sake of simplicity, we will simply refer to these groups as tags. The tags act as work orders so that as “methylation” begins in any cycle, the department head passes on a work order to the employees. Once the employees, who in this case may be proteins, amino acids, or enzymes, receive their work orders, they have been methylated. Though we go on about our lives completely unaware of this elaborate process, methylation is responsible for making, maintaining, and repairing DNA, your genetic code.
Unquestionably, if you cannot create and mend what makes you so unique, there are going to be serious complications. Under optimal conditions, methylation restricts the activity of less beneficial genes while allowing the most advantageous to switch on so that the system runs more successfully. In fact, the methylation pathway serves as a fundamental mechanism for lifelong health and wellbeing by suppressing the appearance of viral or cancer- provoking genes. While this reaction, known as gene expression, has potential for great success, cancer and birth defects are excellent examples of when this process has gone awry.
DNA is Not Destiny: Discover Magazine
An Excellent 7 minute video for lay people on epigenetics & methylation
Another Excellent 7 minute video for lay people on epigenetics & methylation
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Methylation is a key biochemical process that is essential for the proper function of almost all of your body’s systems. It occurs billions of times every second; it helps repair your DNA on a daily basis; it controls homocysteine (an unhealthy compound that can damage blood vessels); it helps recycle molecules needed for detoxification; and it helps maintain mood and keep inflammation in check.
To keep methylation running smoothly you need optimal levels of B vitamins. Without enough B vitamins methylation breaks down, and the results can be catastrophic. In these cases we see more birth defects like spina bifida (as with the Chinese babies), more cases of Down’s syndrome, and more miscarriage.
A breakdown in methylation also puts you at higher risk for conditions like osteoporosis, diabetes, cervical dysplasia and cancer, colon cancer, lung cancer, depression, pediatric cognitive dysfunction ( mood and other behavioral disorders), dementia, and stroke. And like Mr. Roberts and Mr. McNally, you may be at higher risk for cardiovascular disease.
To avoid all of these problems, the key is to maximize methylation. That means avoiding the things that cause your methylation to break down, testing to find out how well your methylation is working, and including the things that support proper methylation. Let’s look at how to do that.
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What does Methylation do? 1 view
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