Vitamin D Receptor “Determines donors”
VDR Taq tt = -/- (green, no defect) tolerates fewer methyl donors
VDR Taq TT = +/+ (red, complete defect) tolerates more methyl donors
Partial or complete defects may mean you will not readily absorb Vit D from sun exposure. This may also contribute to seasonal depression, particularly when the sun is at it's lowest in the fall/winter season. Many studies in the past decade have noted a strong correlation between Vitamin D deficiency and neurological degeneration. In fact, aside from having implications in Parkinson’s and dementia, this SNP is highly associated with Multiple Sclerosis and “atypical” MS. Yet along with the COMT enzyme, the VDR also clearly impacts dopamine levels.
VDR Taq & COMT Status
These two defects have different effects on methyl groups and dopamine levels within the body. The normal for COMT is -/- and reflects efficient clean-up function of dopamine & norepinephrine with less dopamine available to the body. COMT +/+ indicates much less neurotransmitter cleanup with higher levels of nor-epinephrine and dopamine in the system.
The VDR Taq -/- is normal, which may yield optimal Vitamin D levels, yet it also leads to fewer methyl groups overall. Conversely, the abnormal enzyme function reflected as VDR taq +/+ suggests that there may be more methyl groups available overall. This is due to the fact that a well functioning VDR Taq borrows methylcobalamin from the MTR/MTRR region in order to make dopamine and vitamin D. When the VDR Taq enzyme is defunct, it doesn’t use methyl B-12 from this critical region, leaving more methyl groups within the system.
1.Vitamin D with sage & rosemary for enhanced absorption (they provide synergy).
2.Support B-12 levels based on COMT/VDR Taq status (hydroxocobalamin vs. Methylcobalamin).
Examples of various combinations: Methyl Donor tolerance (See list below)
VDR Taq & COMT Status:
*Examples of various combinations:
VDR Taq -/- (more dopamine) along with COMT +/+ (more dopamine) equals a VERY LOW NEED for Methyl Donors. In this case, you have a significant “Methyl Budget”, in that very few, if any, may be tolerated at all. Use methyl donors VERY carefully & sparingly!
VDR Taq +/+ (less dopamine) along with COMT +/+ (more dopamine) equals a neutral state with a mild to moderate "Methyl budget" since there is some need for methyl donors, though its prudent to choose wisely.
VDR Taq +/+ (less dopamine) along with COMT +/- (moderate dopamine) equals need for more methyl donors.
VDR Taq +/- (moderate dopamine) along with COMT +/- (moderate dopamine) equals a neutral state in which some methyl donors are needed with a larger "Methyl budget" since they will be tolerated in mild to moderate doses and combinations, though its prudent to choose wisely.
VDR Taq -/- (higher dopamine) along with COMT +/- (moderate dopamine) equals a more restricted "Methyl budget" because you receive a fair amount of dopamine with both of these enzymes so often cannot tolerate as many methyl donors.
VDR Taq -/- (higher dopamine) Plus COMT -/- (lower dopamine) equals a mild to moderate Methyl budget because you receive a fair amount of dopamine with VDR status to offset COMT status.
VDR Taq +/- (moderate dopamine) along with COMT +/+ (higher dopamine) equals a much more restricted methyl donor state in which only a small amount of methyl donors are needed with a larger "Methyl budget" since they will be tolerated in mild to moderate doses and combinations, though its prudent to choose wisely.
VDR +/- (moderate dopamine) along with COMT -/- (little dopamine) equals very little dopamine overall and therefore requires MORE methyl donors!
VDR Taq +/+ (lower dopamine) plus COMT -/- (lower dopamine) equals a Substantially HIGHER NEED for Methyl Donors! The VDR Taq status here offers little dopamine while COMT status cleans up dopamine normally rather than preserving anything so there is a severe deficit!
METHYL DONORS: (Avoid if comt++ and encourage if comt—or COMT +/- unless VDR status is -/- )
• FgF (not used as much in the United States)
• Curcumin (small amount in HHC multi okay)
• TMG (small amount in HHC multi is okay)
• Methyl B12
• Folapro (1/4 tablet)
• Intrinsic B12 (1/4 tablet)
• Phosphatidylserine can act as one
• Caffeine products
• Idebenone (this is an active version of Co Q 10 & is in many products)
• Methylmate B (dose 3 drops)
Foods: Eggs, spinach, & kale have natural 5 MTHF Caffeine also acts as a methyl donor: Tea, Coffee, Chocolate
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