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By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
………………….

MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]

The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.

L-Methyl Folate is most beneficial to ... ..more

MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

I found this excellent description in Amy Yasko's forum: ch3nutrigenomics.com. It was posted by one of the members on the site- raji: http://www.ch3nutrigenomics...
This is a private blog, but it is a very rich source of information about methylation, nutrigenomics and dietary supplementation

Here is a copy of the post:

"Common Terminology:

Methyl group: A methyl group is simply a single carbon atom bonded to 3 hydrogen atoms (CH3).

Methylation: Transfer of methyl groups from one chemical to another is called methylation. Essentially any chemical compound that has a methyl group as part of its chemical ... ..more

1. Start eating 'clean'. Organic, non-GMO home made meals should become a priority. Eliminating #gluten and dairy to relieve your body from the burden of processing them should also begin.

2. Avoid taking any extra Folic Acid. There is already a lot of it in the nation's food supply, as it is added to [fortified] to many processed foods. If a person has the #MTHFR mutations then #L-Methyl Folate is the better choice. Choose this #supplement carefully.
Folic Acid will get turned into #Dihydrofolate and will be all gone, except for any more you may eat due to ... ..more

Folic ACID will get turned into Dihydrofolate and will be all gone... except for any more you may eat due to eating many fortified cereals and bread products.

A little Folic ACID will not be a problem. The problems occur when the amount of Folic ACID outweighs the availability of L-Methyl Folate regarding the BRAIN since Folic ACID blocks up the #L-Methyl Folate [ #5-MTHF ] #Folate Receptor Alpha receptors and prevents the real thing [5-MTHF] from getting into the brain.

The rest of the body doesn't suffer from too much #Folic ACID....only the brain.
Folic ACID is synthetic ... ..more

Annonymous

What does Methylation do?

  3 years, 8 months ago

The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.

Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more

VDR
Vitamin D Receptor “Determines donors”

VDR Taq tt = -/- (green, no defect) tolerates fewer methyl donors
VDR Taq TT = +/+ (red, complete defect) tolerates more methyl donors
Partial or complete defects may mean you will not readily absorb Vit D from sun exposure. This may also contribute to seasonal depression, particularly when the sun is at it's lowest in the fall/winter season. Many studies in the past decade have noted a strong correlation between Vitamin D deficiency and neurological degeneration. In fact, aside from having implications in Parkinson’s and dementia, this SNP is highly associated with Multiple Sclerosis ... ..more

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MULTICHEMICAL SENSITIVITY…and #MTHFR
#Methyltetrahydrofolate [MTHFR]
The MTHFR Enzyme is in charge of making #L-Methyl Folate which is the final product of that enzymatic reaction.
L-Methyl folate [5-MTHF] is needed to convert #HOMOCYSTEINE into #Methionine.

HOMOCYSTEINE
With an insufficient amount of L-Methyl Folate there may be a buildup of HOMOCYSTEINE. Too much Homocysteine can cause all sorts of problems such as:
1. Increased blood clotting
2. Irritation and damage to the intima [inner lining of blood vessels]
3. Interfere with cartilage development and healing
As a result of the elevated HOMOCYSTEINE the person will be at greater risk of ... ..more

Methylenetetrahydrofolate reductase (MTHFR) supports one's health, well-being and detoxification and can be defective in a fairly large percentage of our population. About 45% of Caucasians, 70% of Hispanics and about 30% of southern Italians have a genetic defect.

The MTHFR gene produces the MTHFR enzyme. This enzyme is responsible for the circulating form of folate. Folate is very important in homocysteine regulation. The MTHFR enzyme metabolizes folic acid into 5-MTHF, which is needed to combine with homocysteine to break it down and to facilitate methylation (detoxification) processes in the body. The MTHFR enzyme is essential for the body to ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

1. BEFORE reading the articles to help prevent miscarriages below PLEASE Keep this in Mind:
Whenever reading articles about folic acid supplementation.. the MOST important thing is to ingest the RIGHT FORM which is FOLATE:
AKA. ... L-Methyl Folate [5-MTHF].------NOT SYNTHETIC = folic acid.
Some of the names for the GOOD L-methyl folate include:
1. 5-L Methyltetrahydrofolate
2. L-methylfolate
3. 5-MTHFR
4. N5-methyl FH4 ----------All of the four terms mean exactly the same thing.

Here's the LINK discussing the RISK of CANCER when taking excess FOLIC Acid.---and why it's so important to get FOLATE instead. http://chriskresser.com ... ..more

Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting terms for a nutrient they really need.

Understanding which form of methylfolate is best must be clear.

Why all the confusion?

Because there are so many different terms used for methylfolate.

By the end, you will understand everything you need to know about methylfolate.

More significantly – you will understand how to pick the right form of methylfolate.

Terms often used for methylfolate are:

Methylfolate
L-MTHF
L-Methylfolate
L-Methylfolate Calcium
D-Methylfolate
D-5-Methylfolate
Levomefolic Acid
Metafolin
5-MTHF
5-Methylfolate
5-Methyltetrahydrofolate
L-5-MTHF
L-5-Methyltetrahydrofolate
6(S)-5-MTHF
6(S)-5-Methyltetrahydrofolate ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Annonymous

Any idea what Methyl Donors are ?

  3 years, 8 months ago

Limit with COMT+/+ or VDR -/-
Unless you are consuming an excessive amount, there is really no need to limit natural foods with methyl or sulfur donors.
Foods: Eggs, Spinach, Kale, & Caffeine—Tea, Coffee, Chocolate
MSM
Melatonin CoQ-10/Idebenone
Carnitine
Theanine
SAMe
Methyl B-12
Curcumin
Quercetin
DMG
TMG
Folapro
Metafolin
Deplin (5-MTHF)
#MethylDonors #Methylation #Supplements ..more