Lipid Donors: Limit for CBS + & NOS +
Foods: High seafood/fish diet
Any transdermal creams
EFA’s: Omega 3’s or #DHA
The goal is to be mindful of accumulating methyl or sulfur donors rather than attempting to limit all of them. Whenever we try to remove everything “bad” in one category, we create imbalances in other categories. The key is balance. For instance, if you love broccoli & garlic yet have the SUOX & CBS defects, just limit the others on the list.
Andy Cutler informs us that many mercury toxic people are intolerant to certain #foods , commonly known as ‘sulfur foods’, which have a high free thiol content. Consuming foods high in thiols raises the circulating thiol levels that in turn mobilizes #mercury and creates symptoms. He notes, “You typically get a couple of hours of feeling good, energized, happy, and then libidinous, then you feel tired, draggy and depressed, which goes on for a day to a week. Of course if you are eating sulfur foods at each meal these all get stacked up and you can never figure out what ... ..more
CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Dr. Yasko considers addressing CBS mutations as first priority aside from addressing the gut.
This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.
CBS defects are actually upregulations. This means the enzyme works too fast. Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia.
The upregulation ... ..more
The Energy or Citric Acid Cycle:
The Krebs cycle, also called the citric acid cycle or the “Energy Cycle,” is a series of chemical reactions that convert food (sugar, protein, and fat) into energy (ATP). It is referred to as a cycle since it should always end where it began. This process occurs through three main stages within each cell:
1). Glycolysis, otherwise known as the breakdown of sugar, yields 2 molecules of ATP, 2 molecules of NADH, and two forms of pyruvate (6 forms of currency in all). This is actually a step that takes place before the energy ... ..more
CBS C699T cystathionine beta synthase AKA The Hole in the Bucket. This Priority # 3 Mutation
Tip! It is crucial to address any gut issues before you thoroughly address the CBS defect. Since chronic gut issues lead to higher bacterial loads, thus leading to higher ammonia production as well as leaky gut (reducing nutrient absorption and increased risk for food sensitivity) this area is paramount. You can begin to address the CBS prior to fully addressing gut issues though they should be done in concert. Since the CBS is one of the most important issues to address, I’ve decided to ... ..more
Sulfur Donors: Limit for CBS+/SUOX+
Unless you are consuming an excessive amount, there is really no need to limit natural foods with methyl or sulfur donors.
Eggs, Broccoli, Cauliflower, Garlic, Onions, & Cabbage
DMSA Glucosamine & Chondroitin Epsom salts/magnesium sulfate
#SulphurDonors #Supplements #Methylation ..more