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What is ACAT Gene Mutation

  4 years, 11 months ago

ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.

Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.

Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.

The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.

Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.

Labs:
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more

Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more

Annonymous

What is an Excitotoxin ?

  4 years, 11 months ago

#Excitotoxins excite the nerve or brain cell to death.

MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more

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Julie Matthews, Author Nourishing Hope: Benefits range dramatically from child to child. Many parents report that their children make wonderful gains in language when starting a special diet, such as gluten-free casein-free – it may be an increase in words, speaking in sentences, or back and forth conversation. Some children make gains in behavior, a reduction in irritability or tantrums, or less hyperactivity. Other children have improvements in the quality of life, relief of digestive upset, fewer colds and infections, and are happier and healthier. While benefits differ, my experience as a Certified Nutrition Consultant specializing in autism for the past ... ..more

These days we don’t live in cabins on the remote Alaskan tundra so you can only do the best you can with the time and resources you have available. Take it one step at a time, and remember that this isn’t just about chronic neurological and autoimmune illness; it affects everyone. Work toward gradual changes and look for suitable alternatives, as even mild improvements can make a significant difference in health.

Remember that this is not an all or nothing lifestyle change. Gradually remove & replace what you 
reasonably can. If you can eliminate 40-50% of these toxins, you have made substantial progress toward 
lifelong neurological health.

There is no need to memorize all of the names for MSG. A good rule of thumb is if it takes you more than 1-2 minutes to read the ingredient list, it has too many #excitotoxins .

Make an #MSG limit & stick with it. Most GF/CF crackers or cookies have at least 3 to 5 hidden chemicals 
while the majority has 5 to 10, this is what makes them taste good.

A box of Hamburger Helper, RiceaRoni or a can of Campbell’s soup has at least 10 to 20 toxic ingredients. Try to limit each product to 5 or less and avoid having more than a few of these foodstuffs mixed in with homemade meals per day.
Remember, there is almost always a reasonable substitute for favorites. It is also important to realize that your taste buds will adapt once accustomed to less MSG.

Compromise to reduce your overall level.
For example, roasted peanut butter is more convenient & flavorful yet higher in glutamates than raw nut butter. Consider mixing 1⁄2 roasted nut butter with 1⁄2 raw nut butter to cut down on content and retain flavor.

Make up enormous batches of meatballs & patties, seasoned taco meat, stuffed meatloaf, chicken soup, chili, whole grain rice, sandwiches, stirfry, sausages, GF/CF pancakes & waffles, etc., and freeze them in meal size batches for busy nights & mornings. It’s much easier to reheat food in a toaster oven than to cook an entire meal three times a day.

If you occasionally eat fast food, limit the burger to “*protein style” with some plain fries. *This is without the bun.

Don’t forget that anything that is so delicious you just can’t stop eating it or often crave it is undoubtedly chock full of excitotoxins, which are triggering the addiction pathway.

Whenever possible, avoid any processed dipping sauces, soy sauce, soups, gravy, Worcester sauce, and many (not all) salad dressings as well as powder packs in foods such as Top Ramen, mac & cheese, bouillon, Accent, taco & other seasoning packs, etc.

Remember, life is short so it’s a compromise; when you really enjoy something and can’t make or find a good substitute ... ..more

The following are the most important issues to address as soon as you can:
Dietary changes: Reducing neurological irritation and achieving Glutamate #GABA balance is critical!
1). Excitotoxins: The more excitotoxins you have coming into your body will only serve to undo many of the helpful measures you’ve already implemented as well as those below. Therefore, I highly recommend a gluten (wheat, rye, barley), casein (*dairy), & soy free diet. See the attached sheets/PDF regarding dietary guidance. In the end, you can only do the best that you can so if finances do not permit this, simply avoid these ... ..more

Julie Matthews: There is overwhelming scientific support for “diet and nutrition intervention” for ADHD and autism. Many studies indicate that children with autism and ADHD have deficiencies in nutrients such as zinc, iron, fatty acids, and that supplements improved symptoms. There are studies showing benefit with nutritional support for autism and ADHD. There are also studies on B6 and magnesium helping improve symptoms of autism. One study on children with autism showed that a multivitamin-mineral formula improved all areas of autistic symptoms studied including: language, play, sociability, hyperactivity, cognition, eye contact, and more. The aggregate science screams “pay attention to ... ..more