“ #23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.
The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.
As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more
Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more
High dose #FolicAcid is the worst thing a person with the MTHFR gene mutation should take.
If a doctor tells a person with the #MTHFR gene mutations to take Folic ACID then that doctor does not really understand anything about the #L-Methyl Folate receptors on the Blood Brain Barrier [BBB]. The doctor does not realize that high dose Folic ACID is just going to block up the L-Methyl Folate Receptors on the BBB. When Folic ACID gets into the L-Methyl Folate Receptors it BLOCKS the receptor and it doesn't get into the brain and neither does the L-Methyl ... ..more
VITAMIN D Receptor BSM Single Nucleotide Polymorphism [SNP] and AUTOIMMUNE DISEASE
PICTURE: Vitamin D Receptor BSM1 [A60890G]
Most doctors don't check for Vitamin D 1,25 because it’s half-life is so very short and the doctors were generally taught in medical school not to bother checking Vitamin D1,25 levels.
People with the Vitamin D Receptor mutations called VDR BSM end up readily converting their vitamin D to D1,25 and meanwhile their Total Vitamin D 25 appears to be low [because it is all getting converted to D 1,25, and their doctors aren’t checking their ... ..more
There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?
I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.
The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more
"As explained well in the revised STTM book, which you should have on hand and bookmarked at the doctors office. The book is in English, Spanish, German and Swedish.
TSH: for diagnosis of hypopituitary, NOT to diagnose or dose your hypothyroidism (unless it’s high). If you allow a doctor to diagnose or dose you by this lab test and range i.e. to say you are normal simply because it’s in range or below 10…you’ll could still be hypothyroid.
Free #T4 and Free #T3 (note the word “free”–important since it measures ... ..more
ME/CFS patients are notoriously very sensitive to medicines and supplements. It’s common to have adverse reactions, or to only be able to tolerate small doses.
Newbies are especially prone to taking too large of doses or going too fast. The following explains how to manage such sensitivity.
Start Low and Go Slow
Whenever you start a new medicine or supplement, it is suggested to practice Start Low and Go Slow.
This means starting with very small doses, much less than a normal dose, such as 1/8 of pill. That way, if you're going ... ..more
Understanding #chronic #fatigue Syndrome #CFS
I left the Mayo Clinic in 2007 a little relieved, a little angry and very poor. Now, I know exactly why I was angry after watching the series of videos below (more about that later). Unfortunately, my anger at being diagnosed with Chronic Fatigue prevented me from doing my own research – I was fed up and I just retreated to my cave for five years to try to heal with diet and lifestyle improvements. That was a big mistake because it appears that a number of researchers have figured out chronic fatigue. If you’ve ... ..more
Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting terms for a nutrient they really need.
Understanding which form of methylfolate is best must be clear.
Why all the confusion?
Because there are so many different terms used for methylfolate.
By the end, you will understand everything you need to know about methylfolate.
More significantly – you will understand how to pick the right form of methylfolate.
Terms often used for methylfolate are:
6(S)-5-Methyltetrahydrofolate ... ..more
The two groups of doctors who are the most likely to know something about the Methyltetrhydrofolate Reductase [MTHFR] enzymatic gene mutation[s] are the OB/GYNs and the Psychiatrists. I would think more Cardiologists would be on top of this topic because of the associated elevated HOMOCYSTEINE levels but they are starting to pay attention. The Geneticists aren't very interested in MTHFR because it isn't lethal or seriously dangerous in and of or by itself.
#Homozygous #MTHFR #Heterozygous #health #Livewello #23andMe #SNPs #Genes #Methylation