MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]
The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.
L-Methyl Folate is most beneficial to ... ..more
MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.
If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:
FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.
DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more
Eating lots of dark green leafy vegetables will be a big benefit as well so we can get some Vitamin B2 [ 3Riboflavin ] which is needed by the #MTHFR Enzyme to have an adequate amount of its co-factor [helper/ Flavin Adenine Dinucleotide [ #FAD ]]
VITAMIN B2 [ #Riboflavin ] is important for the making of #Flavoproteins [FAD] which are cofactors in many biochemical reactions including the biochemical reaction involving the enzyme #MethylTetraHydroFolateReductase [MTHFR] enzyme.
#VitaminB2 is needed to help make FAD which is a cofactor for MTHFR enzyme so that the MTHFR enzyme can better convert #5-10-MethyleenTetraHydroFolate into #L-Methyl Folate.
MTHFR does NOT ... ..more