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MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

The major problem with unnatural synthetic FOLIC ACID is that when there is more #FolicAcid floating around in the blood stream than the real thing…L-Methyl Folate, then the excess Folic ACID can get stuck in the Folate Receptor Alpha [ #FRa ] receptor sites on the Blood Brain Barrier [BBB].

How the “FOLATE CYCLE” connects to the “ #BH4 TetraHydroBiopterine CYCLE” and how this influences the making of Neurotransmitters: #Melatonin, #Dopamine, #Norepinepherine and #Epinephrine [ #Adrenalin ].

Folic ACID completely blocks up the FRa receptor site on the BBB and the entire complex then has to be completely broken down to be recycled.
ONLY ... ..more