Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS
Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more
Introduction to The Vagus Nerve
In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.
The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.
The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more
From Dr Carol Savage
Dr. Yasko may include the Folic ACID in some of her supplements...because there are perhaps individuals who never eat greens or beans, and whose gut is so messed up that they cannot digest greens or beans, and who avoid and never eat the processed foods that are already stuffed with Folic ACID.
The enzyme DiHydroFolate Reductase [DHFR] that converts DiHydroFolate [DHF] into THF can also convert Folic ACID into DHF.
If a person has a faulty "Folate Pathway" and is at risk for NOT making adequate DNA base pairs and they also have ... ..more
By Helen Janneson Bense
A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.
Functions of BH4
Cofactor for all three isotypes of nitric ... ..more
Functional medicine testing involves laboratory tests for biochemical and nutrient imbalances. Testing is individualized for each patient, based on their symptoms and medical history.
“We can also test for imbalances in other areas that give us specific information to create a personalized treatment plan for each patient,” says Dr. Young. Examples include:
Detoxification and biotransformation imbalances
Underlying causes of inflammation
Digestive and absorptive imbalances
Imbalances in gut microbiota
Genetic mutations like MTHFR that influence methylation pathways
COMT, GAD, MAOA/B and addressing methylation too soon can definitely cause neuro-psych issues, but it all comes back to methyl pooling. SNPs in these genes can also contribute: ACE, DAO, MTHFR (e.g., A1298C). Homozygous or 'AA' results for COMT V158M is particularly associated with anxiety & startle response. Quite a few SNPs & quite a few medical conditions can contribute to anxiety, of course (e.g., gut health & bacteria resulting in toxin exposure).
For brain fog / concentration issues, follow up on SNPs affecting ammonia (such as NOS gene, etc.) & BH4 levels (DHPR gene, etc.), also.
With anxiety as a chief ... ..more
#Spirulina provides the raw materials [amino acids] for #DNA and #RNA repair. Spirulina is a rich source of B6 and Folate [B9]. Spirulina also contains #antioxidant phytonutrients called anthocyanins. #Anthocyanins are powerful #anticarcinogenics .
Spirulina has strong anti-microbial effects that help create a proper balance among the #gut flora. Spirulina is helpful in the gut because it helps to controlling the growth of pathogenic [Bad] #bacteria and #yeasts in the digestive system. A proper healthy balance of gut flora is critical for optimal digestion and nutritional absorption. Keeping the gut flora healthy and properly balanced is an important part of #detoxification ... ..more
SYMPTOMS OF TOO MUCH HISTAMINE
“Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine is involved in the inflammatory response.” [wiki]
FOR MORE INFORMATION:
After eating certain histamine aggravating foods or when there is an excessive quantity of released HISTAMINE in the body symptoms may include:
Menstrual pain [worse]
Rhinitis [vasomotor rhinitis]
DIAMINE OXIDASE [DAO]
Reduced function of the enzyme Diamine ... ..more
Lab Tests indicating a need to address Bacterial Imbalances:
History of chronic #ear infections
Maternal history of #Streptococcal infection
History of bacterial #pneumonia
Streptococcus, E coli on #CSA / #GI Profile
Other #bacterial #pathogens on CSA/GI Profile
Elevated kynurenic on #OAT / #Metabolic Test, CONFIRM with CSA/GI Profile
Elevated quinolinic on OAT/Metabolic Test, CONFIRM with CSA/GI Profile
Low gut #pH or high gut pH
High suberic on a #MAP or #OAT
High DHPPA on a MAP or OAT
#Supplements to balance / repopulate GI tract/ decrease E.coli and Strep:
Bowel Support Formula RNA
Special digestive enzymes
VDR Fok ... ..more
ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.
Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.
Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.
The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.
Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more
The Citric Acid Cycle AKA “The Power Company” is essential for processing and converting all dietary nutrients (vitamins, minerals, fats, amino acids) into useable forms of energy just as any power industry processes coal, gas, or oil for energy production. If you visualize this cycle as a clock, each hour represents an area in which one nutrient converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within this clock. This may lead to significant metabolic (chemical processing) imbalances within ... ..more
It’s important to determine which treatments are temporary and only required for initial support and healing vs. those which are essential for life long health and well-being. Many of these will correlate with complete blocks, or full typos in your genetic code while some may be vital supports for partial blocks that lead to substantial illness or disability. Most will require anywhere from 10-15 nutrients for maintenance. Still, some will be indispensable, others will no longer be vital, and many others will only be needed as issues arise.
B). Nerve Repair: Depending on your health problems, this is the ... ..more
The Methionine Cycle is the major work tag (methyl donor) manufacturer. SAMe has over 400 functions in the community. Also serves as the main route through to liver & Waste cycle.
Methionine (SAM) Cycle AKA “SAM’s Corporation,” As SAMe has over 400 known methylation reactions, SAM’s Corporation is the chief work tag producer. It’s also where most of the action occurs since it contains the major thoroughfare to the liver (CBS & transsulfuration). While this often works to its’ advantage, it can also pose a safety risk since failure along this route may result in calamity (see Waste Facility ... ..more
HISTAMINE AND THE GUT By Carol Savage M.D.
Diamine Oxidase (DAO) is the enzyme in the gut responsible for the degradation of HISTAMINE.
Histamine N-MethylTransferase [HNMT] is an enzyme found inside cells so it breaks down histamine within cells. Diamine Oxidase [DAO] is likely “responsible for scavenging extracellular histamine after mediator release.”
Although Diamine Oxidase [DAO] is found everywhere in the body, the bowels are perhaps the most important site of the action of the enzyme DAO.
DAO is synthesized by mature and undamaged enterocytes [gut cells] in the small bowel, so any gut damage would decrease DAO release ... ..more
STEP ONE: Layering in The Foundation
Knowing your Nervous system #dominance is an integral part in establishing the treatment process.
A). Remove or limit triggers:
Processed foods contain excitotoxins, dyes, and #toxic preservatives. It is also crucial to remove obvious food #allergies . Please see Resqua pages on #excitotoxins for more information. This is simply defined and discussed in detail.
B). Begin general support:
Provide a good foundation for your nervous system type and begin nutritional support. Though life threatening reactions would be extremely rare (and to my knowledge, unheard of), moving too quickly can result in more intense symptoms of ... ..more
What does it mean to "spare dopamine"? As mentioned in the above COMT discussion. Not use it? Not create it? ..more
Leaky Gut Syndrome affects millions of people worldwide. While some people show antibodies in their blood indicating an immune system response to the presence of various foods, others merely show signs and symptoms of sensitivity and intolerance. Both of these conditions, and many more, are indicators of leaky gut syndrome.
WHAT IS LEAKY GUT?
Leaky gut syndrome is an un-fancy name given to increased or excessive intestinal permeability. Essentially, the walls of our digestive tracts are compromised - more porous than is healthy and normal, and as a result, particles of food, toxins, bacteria and viruses all “leak” into the bloodstream ... ..more
Lab Tests indicating a need to address #Yeast Imbalances:
Elevated arabinose on OAT/Metabolic test, CONFIRM with CSA/GI Profile
Presence of yeast on CSA/GI Profile
Low gut #pH , CONFIRM with CSA/GI Profile
#Supplements to balance / repopulate GI tract/ decrease yeast:
Rotate #probiotics (one each day of the week):
_ Lactobacillus Plantarum
_ Lactobacillus Reuteri ( Gut Health or Probiotic drops)
_ Suprema Dophilus
_ Nutriclean probiotics
IMF 7 (Immunfactor #7)
Stomach pH Balancing Formula RNA
CCK Support RNA
Mycology Support Formula RNA
Buffer pH supplement ..more