Introduction to The Vagus Nerve
In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.
The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.
The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more
1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.
How does the Livewello App work with your Genetic Raw Data?
2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more
By Helen Janneson Bense
A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.
Functions of BH4
Cofactor for all three isotypes of nitric ... ..more
SYMPTOMS OF TOO MUCH HISTAMINE
“Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine is involved in the inflammatory response.” [wiki]
FOR MORE INFORMATION:
After eating certain histamine aggravating foods or when there is an excessive quantity of released HISTAMINE in the body symptoms may include:
Menstrual pain [worse]
Rhinitis [vasomotor rhinitis]
DIAMINE OXIDASE [DAO]
Reduced function of the enzyme Diamine ... ..more
The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.
Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more
HISTAMINE AND THE GUT By Carol Savage M.D.
Diamine Oxidase (DAO) is the enzyme in the gut responsible for the degradation of HISTAMINE.
Histamine N-MethylTransferase [HNMT] is an enzyme found inside cells so it breaks down histamine within cells. Diamine Oxidase [DAO] is likely “responsible for scavenging extracellular histamine after mediator release.”
Although Diamine Oxidase [DAO] is found everywhere in the body, the bowels are perhaps the most important site of the action of the enzyme DAO.
DAO is synthesized by mature and undamaged enterocytes [gut cells] in the small bowel, so any gut damage would decrease DAO release ... ..more
What does it mean to "spare dopamine"? As mentioned in the above COMT discussion. Not use it? Not create it? ..more
It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.
Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more
￼￼￼￼￼￼￼￼￼￼￼What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.
2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more
~FREE and Unlimited Access to the NEW Livewello SNP Sandbox tool.
With this feature, you can now add up to 250,000 SNPs to your Gene Report.
You now have the power to find out more about SNPs that are not included in other Standard Variance Reports.
~FREE SNP Library accessible at https://livewello.com/snp/l...
This is an example of a Livewello user's shared SNP Template using SNP Sandbox:
Histamine Template (HNMT SNPs): https://livewello.com/conne...
~FREE Compare Report Feature: Your Livewello Gene App allows you to compare and view 2 people's Gene Reports side ... ..more
The #MTHFR mutations can affect the proper function of the immune system, and allergies are a result of immune system dysfunction.
There are many ways that the Methyltetrahydrofolate Reductase [MTHFR] enzyme can weaken the immune system, but I do know that if we do not have enough #SAMe then we cannot deactivate Histamine via the #Histamine N-MethylTransferase [ #HNMT ] enzyme.
If Histamine cannot be inactivated then the symptoms of excess HISTAMINE will be perpetuated.
You can find your Histamine Gene status on your #23andMe Gene Test ..more
From Dr Carol Savage:
DIAMINE OXIDASE [DAO]…HISTAMINE
Histamine is a very important molecule for the human body because it fulfils many vital functions, but too much is not good. Histamine is both produced in the body and taken in with the ingestion of various foods.
Problems develop when there is an EXCESSIVE amount of HISTAMINE or when it is not adequately degraded. In either case histamine will lead to allergic or “Pseudo-allergic Reactions” [reactions that appear to be allergic in nature but are not].
S-Adenyl Methionine [SAMe] is needed to inactivate histamine in ... ..more
After using SNP Sandbox to create your custom collection/template of SNPs, you can share them with others (without sharing your personal information of course). To do so, click on the share link to be taken to the SNP Templates library where you can add your template. After contributing your template to the library, you can share a link to it by clicking on the "Share this resource" button.
This is an example of a SNP Template shared by a LiveWello user using SNP Sandbox:
Histamine SNPs: https://livewello.com/conne...
Yasko Nutrigenomic Panel SNPs: https://livewello.com/resou...
Here ... ..more
#Histamine is most commonly known for it's role in #allergic reactions but it is also involved in other neurological functions and can affect your #emotions as well as behavior. Histamine helps control the #sleep -wake cycle and promotes the release of epinephrine and #norepinephrine . This may be the explanation for red ears and #flushed cheeks in susceptible children and adults with high histamine levels.
High levels have been linked to obsessive-compulsive ( #OCD ) tendencies, #depression , and #headaches . Low levels can contribute to #paranoia , low #libido , #fatigue , and multiple medication sensitivities.
it is important to consider that those with the #CBS ... ..more
To learn more about COMT Gene:
Dr. Richard Deth PhD
Dr. Jill James PhD
1) http://www.ucdmc.ucdavis.ed... (2006 lectures, please scroll down for oxidative Stress Lecture as well).
2) http://www.ucdmc.ucdavis.ed... (2010 Lecture Methylation/Oxidative stress). http://www.youtube.com/watc...
Most of us know histamines through #antihistamine drugs that relieve our suffering from #allergies to pollen, insect bites, and even foods.
Histamine is naturally produced in our body by #mastcells or white blood cells.
Histamine performs different functions by binding with histamine receptors. Depending upon their location, histamine receptors control very different body functions:
Histamine #H1 receptors:
Smooth muscle and endothelial cells affecting skin; blood vessels (Benadryl and Claritin block activity of these receptors)
Histamine #H2 receptors:
Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate
(Histamine H2 receptor antagonist ... ..more