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What is IL13?

  5 years, 2 months ago

This #gene encodes an immunoregulatory cytokine produced primarily by activated #Th2 cells. This #cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, #IL3 , #IL5 , #IL4 , and #CSF2 form a cytokine gene cluster on chromosome 5q, with this #gene particularly close to IL4. [provided ... ..more