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ACAT is Acetyl-Coenzyme A Acetyltransferase [ACAT] [mitochondria]
A block at this point in [ACAT] can lead to increased levels of MMA (Methylmalonic Acid)." ...."MMA may inhibit Succinate CoQ Reductase. The enzyme succinate CoQ Reductase is important in electron transport."
Methylmalonic Acid [MMA] is related to Vitamin B12 biochemistry.

#ACAT is treated with Adenosylcobalmin (for high MMA), bile salts, policosanol, pancreatic enzymes, vitamin K, vitamin E, lactoferrin, nucleotides, and CQ10. ...but which ones, how much and how long you take each of these (if at all) depends on your other mutations as well as biochemical testing. Things you want to monitor ... ..more

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Annonymous

What is ACAT Gene Mutation

  5 years, 2 months ago

ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.

Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.

Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.

The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.

Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.

Labs:
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more

Lab Tests indicating a need to address #Yeast Imbalances:
Elevated arabinose on OAT/Metabolic test, CONFIRM with CSA/GI Profile
Presence of yeast on CSA/GI Profile
Low gut #pH , CONFIRM with CSA/GI Profile

#Supplements to balance / repopulate GI tract/ decrease yeast:
Rotate #probiotics (one each day of the week):
_ Florastor
_ Lactobacillus Plantarum
_ Lactobacillus Reuteri ( Gut Health or Probiotic drops)
_ Suprema Dophilus
_ Allerdophilus
_ FloraElite
_ Nutriclean probiotics
Candisol
IMF 7 (Immunfactor #7)
Lactoferrin
Nautromycin Spray
Naturomycin Caps
Bactisolve
Stomach pH Balancing Formula RNA
CCK Support RNA
Mycology Support Formula RNA
Buffer pH supplement ..more

Elevated arabinose on OAT/Metabolic test, CONFIRM with CSA/GI Profile
Presence of yeast on CSA/GI Profile
Low gut pH, CONFIRM with CSA/GI Profile

Supports to balance / repopulate GI tract/ decrease yeast:
Rotate probiotics (one each day of the week):
_ #Florastor
_ #Lactobacillus #Plantarum
_ Lactobacillus #Reuteri ( Gut Health or Probiotic drops)
_ Suprema Dophilus
_ Allerdophilus
_ FloraElite
_ #Nutriclean #probiotics
#Candisol
IMF 7 (Immunfactor #7)
Lactoferrin
Nautromycin Spray
Naturomycin Caps
Bactisolve
Stomach pH Balancing Formula RNA
CCK Support RNA
Mycology Support Formula RNA
Buffer pH #supplement
#Yeast ..more

Annonymous

What is the Krebs Cycle?

  5 years, 2 months ago

The Energy or Citric Acid Cycle:
The Krebs cycle, also called the citric acid cycle or the “Energy Cycle,” is a series of chemical reactions that convert food (sugar, protein, and fat) into energy (ATP). It is referred to as a cycle since it should always end where it began. This process occurs through three main stages within each cell:

1). Glycolysis, otherwise known as the breakdown of sugar, yields 2 molecules of ATP, 2 molecules of NADH, and two forms of pyruvate (6 forms of currency in all). This is actually a step that takes place before the energy ... ..more

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Annonymous

What is the AHCY Mutation?

  5 years, 2 months ago

The AHCY (Adenosylhomocysteine Hydrolase) Mutation activates Homocysteine.
This defect is a prime example of just how challenging nutrigenomics medicine is, particularly when trying to sort through methylation’s domino effect. This zone activates SAM into Homocysteine, which is then utilized within the system or eliminated through the CBS enzyme. When AHCY defects are present, one could have the MTHFR C677T enzyme mutation yet still have normal homocysteine levels. And, if a coexisting CBS upregulation is present, homocysteine levels may be even lower, despite having complete C677T and/or BHMT defects. Furthermore, when such AHCY defects are present, there is less ... ..more