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MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

Annonymous

What is MTHFR A1298C Gene Mutation ?

  4 years, 2 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

COMT, GAD, MAOA/B and addressing methylation too soon can definitely cause neuro-psych issues, but it all comes back to methyl pooling. SNPs in these genes can also contribute: ACE, DAO, MTHFR (e.g., A1298C). Homozygous or 'AA' results for COMT V158M is particularly associated with anxiety & startle response. Quite a few SNPs & quite a few medical conditions can contribute to anxiety, of course (e.g., gut health & bacteria resulting in toxin exposure).

For brain fog / concentration issues, follow up on SNPs affecting ammonia (such as NOS gene, etc.) & BH4 levels (DHPR gene, etc.), also.

With anxiety as a chief ... ..more

1. Start eating 'clean'. Organic, non-GMO home made meals should become a priority. Eliminating #gluten and dairy to relieve your body from the burden of processing them should also begin.

2. Avoid taking any extra Folic Acid. There is already a lot of it in the nation's food supply, as it is added to [fortified] to many processed foods. If a person has the #MTHFR mutations then #L-Methyl Folate is the better choice. Choose this #supplement carefully.
Folic Acid will get turned into #Dihydrofolate and will be all gone, except for any more you may eat due to ... ..more

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Folic ACID will get turned into Dihydrofolate and will be all gone... except for any more you may eat due to eating many fortified cereals and bread products.

A little Folic ACID will not be a problem. The problems occur when the amount of Folic ACID outweighs the availability of L-Methyl Folate regarding the BRAIN since Folic ACID blocks up the #L-Methyl Folate [ #5-MTHF ] #Folate Receptor Alpha receptors and prevents the real thing [5-MTHF] from getting into the brain.

The rest of the body doesn't suffer from too much #Folic ACID....only the brain.
Folic ACID is synthetic ... ..more

Annonymous

What does the COMT Gene Mutation mean?

  4 years, 6 months ago

What does it mean to "spare dopamine"? As mentioned in the above COMT discussion. Not use it? Not create it?  ..more

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#Neurotransmitter
Lab Tests indicating a need for #Glutamate #GABA balance:
Elevated glutamate, #glutamine #glutamic acid on urine AA test
Elevated #aspartate #aspartic acid on urine AA test
Low GABA (gamma aminobutyric acid) on a urine AA test
Low GABA on a Neurotransmitter test
Elevated #quinolinic on #OAT #Metabolic Test
#Seizures
#Stims
Poor eye contact
#Aggressive behavior

#Supplements to balance Glutamate and GABA:
Nerve Calm Formula RNA
Comfort RNA
Be Calm Glutamate Spray/Gaba Spray
Melatonin Sleep Spray
#Progesterone cream- Pro-Gest Body Cream
GABA
Pycnogenol
Grape Seed Extract
Valerian Root
Jujube
#Lithium Orotate based on UEE levels
L-Theanine
Taurine (not for ... ..more

You should take the B12 first, followed up by methylfolate later on to avoid methyl-trapping. Lithium can be used at night. You can read further about it if you're interested in the specifics here: http://www.ncbi.nlm.nih.gov... ..more

Elevated #glutamate , glutamine, glutamic acid on urine AA test
Elevated aspartate, aspartic acid on urine AA test
Low #GABA (gamma aminobutyric acid) on a urine AA test
Low GABA on a Neurotransmitter test
Elevated quinolinic on OAT/Metabolic Test
#Seizures
#Stims
Poor eye contact
#Aggressive behavior

Supports to balance Glutamate and GABA:
Nerve Calm Formula RNA
Comfort RNA
Be Calm Glutamate Spray/Gaba Spray
Melatonin Sleep Spray
Progesterone cream- Pro-Gest Body Cream
GABA
#Pycnogenol
Grape Seed Extract
Valerian Root
Jujube
#Lithium Orotate based on UEE levels
L-Theanine
Taurine (not for CBS + or SUOX Mutation unless suggested on testing)

#supplements ..more

1). #MTHFR #A1298C + #Liver & #BH4 support
Start at a few crumbs per day and very gradually, go up over several weeks’ time (generally 4-6 weeks). The goal is 1⁄2 to 1 capsule daily ($54.95/60 caps & $29.95/30 caps). This is whether you have the MTHFR A1298C defect or not.

2). Black Bear Spray or Get B12 Spray
Start at 1-2 sprays per day and very gradually work up to 3-5 sprays once or twice daily. A tip for adults who develop headaches with wine, it is very likely that you are sensitive to sulfites and the ... ..more

Annonymous

Lithium orotate or Lithium carbonate?

  4 years, 6 months ago
Annonymous

What does the COMT Gene Mutation mean?

  4 years, 6 months ago

To learn more about COMT Gene:
Dr. Richard Deth PhD
http://wn.com/oxidative_str...

Dr. Jill James PhD
1) http://www.ucdmc.ucdavis.ed... (2006 lectures, please scroll down for oxidative Stress Lecture as well).

2) http://www.ucdmc.ucdavis.ed... (2010 Lecture Methylation/Oxidative stress). http://www.youtube.com/watc...
 ..more

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Annonymous

Any thoughts on MTHFR and Lithium ?

  4 years, 5 months ago

#MTHFR #Lithium
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.

Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more

Understandably, human beings adapt much more readily to positive reinforcement, avoiding the negative experiences. While there are many approaches to #detox , experience has shown that it takes commitment on par with taking a seminar or, when really ill, getting through a longer flu or hospitalization. It takes an extensive amount of time, energy, and dedication, which is often extremely difficult for those who work full-time and/or have a difficult time slowing down. Regardless of the strategy, if you relegate the process to moments of “when I get time,” you cannot be successful. Many make the mistake of trying to ... ..more