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VDR
Vitamin D Receptor “Determines donors”

VDR Taq tt = -/- (green, no defect) tolerates fewer methyl donors
VDR Taq TT = +/+ (red, complete defect) tolerates more methyl donors
Partial or complete defects may mean you will not readily absorb Vit D from sun exposure. This may also contribute to seasonal depression, particularly when the sun is at it's lowest in the fall/winter season. Many studies in the past decade have noted a strong correlation between Vitamin D deficiency and neurological degeneration. In fact, aside from having implications in Parkinson’s and dementia, this SNP is highly associated with Multiple Sclerosis ... ..more

#23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more

A Sample Standard Livewello 23andMe Gene Report:
https://livewello.com/conne...
[ This is just the Standard report. Livewello's Gene App also allows you to get your report with up to 297,000 SNPs which is the actual number of SNPs in your 23andMe Raw Data result ].

For those of who've received your 23andMe Raw Data and you're trying to decide which App works best for you, use this list of features as a comparison guide: https://livewello.com/23andMe
#Homozygous #MTHFR #Heterozygous #health #Livewello #23andMe #SNPs #Genes #Methylation #SampleGeneReport ..more

#23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more

Annonymous

Why is my B12 supplement not working?

  2 years, 10 months ago

Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

Annonymous

How can I stimulate my vagus nerve

  2 years, 8 months ago

SOURCE: http://selfhacked.com/2015/...


Introduction to The Vagus Nerve

In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.

The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.

The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more

Annonymous

Why is my B12 supplement not working?

  2 years, 10 months ago

Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

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Annonymous

What does the Livewello Gene App do?

  3 years, 1 month ago

The Raw Data you receive from 23andMe can be translated by Livewello for a 1-time fee of $19:95. LiveWello is unique because it gives users much more than just a 900 SNP Gene report: LiveWello will give you your report for 600,000 SNPs, AND attaches 11 resources for learning to each Gene.

Updates are FREE for Livewello users: Free updates are crucial as it allows users get their results for new SNPs when 23andMe adds new SNPS to your raw data during their Chip updates. It is also crucial for when new research is added to information about ... ..more

Published by Frank Marshall · March 26, 2015 at 2:12pm

The Compare Reports Tool allows you to view and compare up to 5 different people's Gene variance reports side-by-side. Comparing your Gene Reports provides side-by-side comparison with other profiles like the friends or family members in your LiveWello Account.

This tool is for those who have received their Gene results from 23andMe AncestryDNA or almost any other Gene Testing company.

Before you can do this, please make sure that:



--Everyone has generated the same Livewello Gene report you want to compare.


--Everyone has exchanged their "Add-Me" link with each ... ..more

Annonymous

What is MTHFR A1298C Gene Mutation ?

  3 years, 12 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

This is a statement from Dr. Iwegbue, Founder and Lead Developer of the Livewello Gene App:

I'd like to share with you the reason why 23andMe Variance Report results sometimes differ depending on the App used. Results are determined by the Minor Allele used:
All of LiveWello's Minor Allele information is retrieved directly from dbSNP. A link to dbSNP is added to every SNP in a Livewello Gene Variance Report. That way, a user and their Practitioner can verify minor allele information for themselves.

At Livewello, we only use the forward strand for interpreting all our SNPs. This ... ..more

Annonymous

What is The Citric Acid Cycle ?

  4 years, 3 months ago

The Citric Acid Cycle AKA “The Power Company” is essential for processing and converting all dietary nutrients (vitamins, minerals, fats, amino acids) into useable forms of energy just as any power industry processes coal, gas, or oil for energy production. If you visualize this cycle as a clock, each hour represents an area in which one nutrient converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within this clock. This may lead to significant metabolic (chemical processing) imbalances within ... ..more

Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more