ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.
Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.
Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.
The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.
Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more
The Citric Acid Cycle AKA “The Power Company” is essential for processing and converting all dietary nutrients (vitamins, minerals, fats, amino acids) into useable forms of energy just as any power industry processes coal, gas, or oil for energy production. If you visualize this cycle as a clock, each hour represents an area in which one nutrient converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within this clock. This may lead to significant metabolic (chemical processing) imbalances within ... ..more
These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle
( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility ... ..more
#Excitotoxins excite the nerve or brain cell to death.
MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more
Although every living being requires oxygen for survival, oxygen is actually highly reactive and can damage living organisms by producing reactive oxygen species. In people, these unstable oxygen molecules occur with everyday living, during the normal breakdown of food or even as the #immune system is activated to fight off #bacteria & #virus. Other exposures include: smoking, using drugs or drinking too much alcohol, eating fried foods and refined sugars, air & water pollution, consuming #excitotoxins (MSG), dyes, toxic preservatives, and pesticides, as well as countless other contaminants that lead to widespread free radical damage, particularly once the body’s natural #antioxidants ... ..more
#Sympathetic Nervous System “Fight or flight” or “Type A’s”
There are 3 basic #SNS Dominant subtypes: Basic, Extreme, & Inefficient SNS Dominant types. The following is a summary of the average SNS Dominant types.
Personality traits vary widely in this group depending on whether they are more analytical vs. emotional. For instance, more emotionally based SNS Dominants are likely to be more volatile and “nervous” whereas the more analytical type does not.
The sympathetic nervous system (SNS) activates the glands and organs that defend the body against attack, whether it is running from a saber toothed tiger or you are struggling with a dreadful job and difficult boss. It is called the fight or flight system and once activated, it directs more blood to the muscles, #adrenals and the brain yet away from the digestive organs and skin. The adrenals pump out #epinephrine while the sympathetic nerve endings throughout the body release #norepinephrine . This system is #catabolic , which simply means that energy is used to prepare for defense, rather than for nourishment, healing, or waste removal. #Sympathetic activity triggers the thyroid and adrenal glands to provide extra energy for fighting or running away. The heart rate and blood pressure also increase, just as the blood flow to the digestive system and kidneys decreases. This process is largely due to the intensified release of stimulating chemicals, known as #neurotransmitters #epinephrine and #norepinephrine . While this activity is critical for survival, those who have chronic activation of the SNS often develop #anxiety, #insomnia , heart racing or disease (heart failure), and adrenal #fatigue . They also have “goose bumps” more frequently than other types and tend to do best in warmer weather. A Sympathetic Dominant Nervous System often leads to significant gastro-intestinal issues due to the poor #digestion of meats and fats. These folks often feel as though food "sits like a rock in my gut". Due to the rising levels of Norepinephrine (the body’s flight or fight neurotransmitter), digestion shuts down to reserve precious resources for survival. Chronic activation can lead many to feel agitated, jittery, wired, & restless as well as prone to sleep disturbances and anxiety. They may also experience the vicious cycle of the “Wired but tired” sensation when eating an inappropriate diet or taking the wrong supplements, which in their case, is filled with sweets and other junk foods or heavy proteins. When a dysfunctional sympathetic nervous system reigns supreme, one may experience anxiety, stress, or feelings of panic, which should normally only occur in response to a perceived threat. Subsequently, they may overreact to even the mildest of daily troubles.
These individuals often start out thin and active yet poor diets—usually filled with sweets and starchy carbs often lead to later weight gain. When busy or stressed, they frequently forget to eat regularly, if at all. They are often pale, do not tolerate cold weather and tend to have colder hands & feet. Such individuals are often impatient and easily frustrated or angered, yet it appears to quickly pass. They often make for volatile partners and bosses, in that they frequently explode; yet minutes later have already moved on. They are also frequently viewed as “intense,” “aloof,” or “bold,” and have a tendency of “sticking their foot in their mouths” by being too aggressive or forward. Nevertheless, #genetic & environmental factors influence this area considerably.
They are also very driven, ambitious, and motivated people who may excel in academics or in high energy vocations that require multi tasking and social interaction. Many also enjoy a stimulating debate or confrontation (attorneys, politicians, generals). When healthy ... ..more
Monosodium glutamate #MSG
Yeast food or yeast nutrient Autolyzed yeast
Soy protein concentrate Soy protein isolate
Whey protein concentrate Whey protein isolate
AuxiGro (plant enhancer) Ajinomoto
*Examples of hydrolyzed*
Pea, soy, wheat, whey, corn, & vegetable protein.
This additive is the most harmful version as it contains all 3 excitotoxins: glutamate, aspartate, & cysteine as well as chemicals known to be carcinogenic.
*Some #vaccines also include ... ..more
Carrageenan Guar gum
Locust bean gum Bouillon and broth Stock
Any “flavors” or “flavoring” Maltodextrin
Anything “enzyme modified”
Anything containing “enzymes”
Soy sauce extract
Anything “protein fortified” Anything “fermented”
*Any ingredients listed as "seasoning," “spices,” "natural flavoring," or "protein fortified.
*Below are #MSG Flavor enhancers.
If these are present, MSG is as well:
Disodium 5'- ribonucleotides!
low calorie low fat foods almost always have multiple versions of MSG and/or aspartame or Amino Sweet included.
Corn starch ... ..more
These days we don’t live in cabins on the remote Alaskan tundra so you can only do the best you can with the time and resources you have available. Take it one step at a time, and remember that this isn’t just about chronic neurological and autoimmune illness; it affects everyone. Work toward gradual changes and look for suitable alternatives, as even mild improvements can make a significant difference in health.
Remember that this is not an all or nothing lifestyle change. Gradually remove & replace what you reasonably can. If you can eliminate 40-50% of these toxins, you have made substantial progress toward lifelong neurological health.
There is no need to memorize all of the names for MSG. A good rule of thumb is if it takes you more than 1-2 minutes to read the ingredient list, it has too many #excitotoxins .
Make an #MSG limit & stick with it. Most GF/CF crackers or cookies have at least 3 to 5 hidden chemicals while the majority has 5 to 10, this is what makes them taste good.
A box of Hamburger Helper, RiceaRoni or a can of Campbell’s soup has at least 10 to 20 toxic ingredients. Try to limit each product to 5 or less and avoid having more than a few of these foodstuffs mixed in with homemade meals per day.
Remember, there is almost always a reasonable substitute for favorites. It is also important to realize that your taste buds will adapt once accustomed to less MSG.
Compromise to reduce your overall level.
For example, roasted peanut butter is more convenient & flavorful yet higher in glutamates than raw nut butter. Consider mixing 1⁄2 roasted nut butter with 1⁄2 raw nut butter to cut down on content and retain flavor.
Make up enormous batches of meatballs & patties, seasoned taco meat, stuffed meatloaf, chicken soup, chili, whole grain rice, sandwiches, stirfry, sausages, GF/CF pancakes & waffles, etc., and freeze them in meal size batches for busy nights & mornings. It’s much easier to reheat food in a toaster oven than to cook an entire meal three times a day.
If you occasionally eat fast food, limit the burger to “*protein style” with some plain fries. *This is without the bun.
Don’t forget that anything that is so delicious you just can’t stop eating it or often crave it is undoubtedly chock full of excitotoxins, which are triggering the addiction pathway.
Whenever possible, avoid any processed dipping sauces, soy sauce, soups, gravy, Worcester sauce, and many (not all) salad dressings as well as powder packs in foods such as Top Ramen, mac & cheese, bouillon, Accent, taco & other seasoning packs, etc.
Remember, life is short so it’s a compromise; when you really enjoy something and can’t make or find a good substitute ... ..more
The following are the most important issues to address as soon as you can:
Dietary changes: Reducing neurological irritation and achieving Glutamate #GABA balance is critical!
1). Excitotoxins: The more excitotoxins you have coming into your body will only serve to undo many of the helpful measures you’ve already implemented as well as those below. Therefore, I highly recommend a gluten (wheat, rye, barley), casein (*dairy), & soy free diet. See the attached sheets/PDF regarding dietary guidance. In the end, you can only do the best that you can so if finances do not permit this, simply avoid these ... ..more
Tylenol/Acetaminophen, Copper, iron, taurine, *calcium, plain folate & folic acid, glycine, glutathione, and “chelated minerals” as these mineral versions often contain one of the following: aspartic acid/aspartame, glutamic acid/glutamate/Monosodium glutamate(MSG), which are all excitotoxins. *Those who are parasympathetic Dominants will probably require calcium, as will those who are closer to recovery once excitotoxicity is well regulated.