COMT and VDR Genes and DOPAMINE and NOREPINEPHERINE…and people sensitive to methyl donors.
Those with the Vitamin D Receptor Taq [VDR Taq (+/+)] mutations do not make Dopamine and therefore Norepinepherine very well.
Those with the Catechol-O-Methyl Transferase [COMT +/+] mutations cannot break down Dopamine and Norepinephrine very well.
A normal VDR [-/-] and the abnormal COMT [+/+] enzyme essentially aggravate the situation so that the concentration of Dopamine may be increased.
When the person has a perfect VDR taq [-/-] and they have the COMT [+/+] mutations then:
The good working VDR taq [-/-] allows them to make plenty of Dopamine.
The lousy COMT [+/+] causes ... ..more
The major problem with unnatural synthetic FOLIC ACID is that when there is more #FolicAcid floating around in the blood stream than the real thing…L-Methyl Folate, then the excess Folic ACID can get stuck in the Folate Receptor Alpha [ #FRa ] receptor sites on the Blood Brain Barrier [BBB].
How the “FOLATE CYCLE” connects to the “ #BH4 TetraHydroBiopterine CYCLE” and how this influences the making of Neurotransmitters: #Melatonin, #Dopamine, #Norepinepherine and #Epinephrine [ #Adrenalin ].
Folic ACID completely blocks up the FRa receptor site on the BBB and the entire complex then has to be completely broken down to be recycled.
ONLY ... ..more