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ACAT is Acetyl-Coenzyme A Acetyltransferase [ACAT] [mitochondria]
A block at this point in [ACAT] can lead to increased levels of MMA (Methylmalonic Acid)." ...."MMA may inhibit Succinate CoQ Reductase. The enzyme succinate CoQ Reductase is important in electron transport."
Methylmalonic Acid [MMA] is related to Vitamin B12 biochemistry.

#ACAT is treated with Adenosylcobalmin (for high MMA), bile salts, policosanol, pancreatic enzymes, vitamin K, vitamin E, lactoferrin, nucleotides, and CQ10. ...but which ones, how much and how long you take each of these (if at all) depends on your other mutations as well as biochemical testing. Things you want to monitor ... ..more

Annonymous

What is ACAT Gene Mutation

  4 years, 3 months ago

ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.

Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.

Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.

The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.

Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.

Labs:
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more

Annonymous

What is the Folate Cycle ?

  4 years, 3 months ago

The Folate Cycle Produces organic, homegrown RNA & DNA. Converts folate into usable forms to keep HCY* in check & sends on to SAM’s for more work tags. *HCY/Homocysteine

The Folate Cycle is the “Organic Farming Region” where everything is homegrown. This Region grows “organic” work tags (methyl groups) and is instrumental in the front-line production of new RNA and DNA. Still, this plantation is a bit old fashioned, employing a chain gang (homocysteine) to help them get the work done. Though rarely considered in everyday life, RNA & DNA are essential to making you unique, as well as directing health ... ..more

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#CBS #NOS Gene Mutation
• Flapping or hand tremors
• Dark circles under eyes
• Disorientation, and brain fog
• Hyperactive reflexes
• NMDA receptor activation, leading to glutamate excitotoxicity
• Tremor of the hands
• Paranoia, panic attacks
• Memory loss
• Headaches
• Irritability
• Hyperventilation (often associated with decreased Carbon dioxide/CO2)
• Central nervous system toxicity
• Dementia
• Seizures

How to reduce Ammonia levels:
The following examples assist in balancing this toxic waste
• Yucca with meals/protein snacks
• Charcoal flush (only 1-2 x week) after last meal of the day (typically 9-10PM)
• CBS/NOS Caps
• MTHFR A1298C Caps (L-Biopterrin increases BH4 levels and the milk thistle also provides ammonia ... ..more

Consistently elevated glucose
Consistently low glucose
Elevated triglycerides
VDR Fok Ff ( -+) or VDR Fok f f (+ +)
Imbalances in pancreatic elastase on a CSA/GI Profile
Imbalances in chymotrpsin values on a CSA/GI Profile
Imbalances in SCFA (Iso-butyrate, iso-valerate and n-valerate) on CSA/GI Profile
Imbalances in LCFA on a CSA/GI Profile

Supports for Pancreatic Health:
Prolongevity Formula RNA
CCK Support Formula RNA
VDR FOK Compounded Supplement
Vita D-Light Spray OR Vitamin D
Special Digestive Enzymes With Each Meal
Fenugreek
Chromium
Red Rice Yeast
Vanadyl
GABA
 ..more

Annonymous

How can I care for my Pancreas

  4 years, 3 months ago

Lab Tests indicating a need for Pancreatic Support:
Consistently elevated glucose
Consistently low glucose
Elevated triglycerides
#VDR Fok Ff ( -+) or VDR Fok f f (+ +)
Imbalances in pancreatic elastase on a CSA/GI Profile
Imbalances in chymotrpsin values on a CSA/GI Profile
Imbalances in SCFA (Iso-butyrate, iso-valerate and n-valerate) on CSA/GI Profile
Imbalances in LCFA on a CSA/GI Profile

#Supplements for #Pancreatic Health:
Prolongevity Formula RNA
CCK Support Formula RNA
VDR FOK Compounded Supplement
Vita D-Light Spray OR Vitamin D
Special Digestive Enzymes With Each Meal
Fenugreek
Chromium
Red Rice Yeast
Vanadyl
#GABA
#Methylation ..more

To find out if your #gut is #metabolizing or #absorbing #fat you can have your doctor run a Fecal fat and a #Sehcat test for #bile acid #malabsorption
Reasons can be Low #triglycerides, low #cholesterol , #choline deficiency, #FattyLiver......

Malabsorption can be described as the body’s inability to absorb certain nutrients from the #gastrointestinal ( #GI ) tract. This problem has become one of the leading health concerns all across the US today. There are several different types of malabsorption syndromes and the most common ones include the inability to absorb fat, proteins, vitamins and sugar. The different factors that could lead ... ..more

1). #MTHFR #A1298C + #Liver & #BH4 support
Start at a few crumbs per day and very gradually, go up over several weeks’ time (generally 4-6 weeks). The goal is 1⁄2 to 1 capsule daily ($54.95/60 caps & $29.95/30 caps). This is whether you have the MTHFR A1298C defect or not.

2). Black Bear Spray or Get B12 Spray
Start at 1-2 sprays per day and very gradually work up to 3-5 sprays once or twice daily. A tip for adults who develop headaches with wine, it is very likely that you are sensitive to sulfites and the ... ..more