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Annonymous

What does a CBS Gene Mutation mean ?

  3 years, 8 months ago

CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Dr. Yasko considers addressing CBS mutations as first priority aside from addressing the gut.
This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.

CBS defects are actually upregulations. This means the enzyme works too fast. Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia.

The upregulation ... ..more

Annonymous

How to generate a variance report

  2 years, 2 months ago

Here are the steps to generate your report;

- Go to your 23andMe account, and download your raw data to your desktop
- Go to https://livewello.com/snps/...
- Choose the file from your desktop
- Click the upload button, and the rest should happen automatically. The entire process should take less than 5 minutes depending on your network connection

https://vimeo.com/97308750

#Livewello ..more

Annonymous

How do I generate a report?

  3 years, 6 months ago

Here are the steps to generate your report;

- Go to your 23andMe account, and download your raw data to your desktop
- Go to https://livewello.com/snps/...
- Choose the file from your desktop
- Click the upload button, and the rest should happen automatically. The entire process should take less than 5 minutes depending on your network connection

https://vimeo.com/97308750

#Livewello ..more

VDR Taq has a minor allele (MAF) of "G":
http://www.ncbi.nlm.nih.gov...

Here are some studies that reference VDR Taq (rs731236):

"We observed that women with GG (rs731236), ... were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism"
http://www.ncbi.nlm.nih.gov...

"The VDR polymorphism, TaqI (rs731236), was associated with a 26 % risk reduction (TT vs. CC, OR 0.74)"
http://www.ncbi.nlm.nih.gov...

All ... ..more

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Annonymous

What does the Livewello Gene App do?

  2 years, 5 months ago

The Raw Data you receive from 23andMe can be translated by Livewello for a 1-time fee of $19:95. LiveWello is unique because it gives users much more than just a 900 SNP Gene report: LiveWello will give you your report for 600,000 SNPs, AND attaches 11 resources for learning to each Gene.

Updates are FREE for Livewello users: Free updates are crucial as it allows users get their results for new SNPs when 23andMe adds new SNPS to your raw data during their Chip updates. It is also crucial for when new research is added to information about ... ..more

1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.

How does the Livewello App work with your Genetic Raw Data?
https://docs.google.com/a/l...

2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more

For most people a Variance report with only 300 SNPs doesn't paint a complete picture.As such, they will need to delve deeper into their genome to figure out what is going on. Most people do not realize that their 23andMe Raw Data comes with 600,000 Disease related SNPs. All of which have research being added to the PubMed Database almost daily. Every Gene in your Livewello Report has a live connection to up-to-date research information from PubMed, SNPedia, WikiGenes, Malacards, GHR, Medline, OMIM, dbSNP, Ensembl and Google Scholar. New information and Research is being added almost daily ... ..more

This Livewello feature helps you find and generate your own results on Genes that Genome wide Research Studies have associated to certain Health Conditions based on research studies.

1) Go to: https://livewello.com/gwas and enter the name of your health condition. If research has been done on it, the SNPs/Genes and research studies associated with that health condition will pull up.

2) Once it does, click "copy to sandbox" and

3) Click build SNP Template to view your own report.

EXAMPLES:

HYPOTHYROIDISM GENES: https://livewello.com/snps/...
ULCERATIVE COLITIS GENES: https://livewello.com/snps/...

#Livewello ..more

Annonymous

What is SNP Sandbox?

  2 years, 5 months ago

The Sandbox tool is for creating an unlimited number of customized Health Reports with your raw data from 23andMe AncestryDNA or most other personal genomics testing companies. You can use it to create a customized report based on any Gene or SNP name you want added to it. It works best once you upload your raw data file.

This tool allows you to add thousands of SNPs of YOUR choice to your Report. You can use it to add SNPs to your Report that are not in your Standard Variance Report. So, if you've received your 23andMe, Ancestry, FTDNA ... ..more

Published by Frank Marshall · March 26, 2015 at 2:12pm

The Compare Reports Tool allows you to view and compare up to 5 different people's Gene variance reports side-by-side. Comparing your Gene Reports provides side-by-side comparison with other profiles like the friends or family members in your LiveWello Account.

This tool is for those who have received their Gene results from 23andMe AncestryDNA or almost any other Gene Testing company.

Before you can do this, please make sure that:



--Everyone has generated the same Livewello Gene report you want to compare.


--Everyone has exchanged their "Add-Me" link with each ... ..more

You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More

6 Ways A DNA Test Can Help You Optimize Your Diet

Matching Genes and Vitamins. A Personalized Plan May Be in Your Future

Why would you need to run a Genetics test?
https://docs.google.com/doc...

LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!

b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas

DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more

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A Standard Gene Report with information looks like this:  https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.

1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more

Vimeo

MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
………………….

MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]

The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.

L-Methyl Folate is most beneficial to ... ..more

MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

Whenever you need to find a SNP/Gene, first search the Gene Library at: https://livewello.com/snps/...
As long as a SNP is in your Raw Data with an rsiD, LiveWello will have it. Livewello comes with 600,000 SNPs!!!

If it's not in the library, use SNP Sandbox: https://livewello.com/snps/... 
Sandbox customizes Gene reports based on a Gene Name or any combination of SNPs. You can then share your template to the Gene Library and click “view report” to see your results for the SNPs in that Template.

EXAMPLE of Template built with SNP Sandbox ... ..more

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

If it is not already in the Gene Library https://livewello.com/snps/... then:

1) Go to https://livewello.com/gwas Read about the GWAS tool If a condition is not listed there, solid research connecting genes to that health condition, have not been found or made.

2) Type in the health condition slowly and you'll start to see options pull up. Select the appropriate one. Results showing rsIDs and Genes will pull up. If you'd like a detailed report, we suggest you go through each PubMed citation and click the "Read Pubmed Citation" button. It will open ... ..more

Physicians don't always know what to do with your genetic information because epigenetics and pharmacogenomics are relatively new fields, and everyone is trying to catch up.  Also Traditional/Allopathic physicians have very limited time in which to  go over all the information that you hand over to them, so the best way to present them with new information like this, is to share a link to your Report and make sure you tell them to read the associated medical references that come with your App. For instance, every Gene in the LiveWello Gene App report is directly linked to ... ..more

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