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I found this excellent description in Amy Yasko's forum: ch3nutrigenomics.com. It was posted by one of the members on the site- raji: http://www.ch3nutrigenomics...
This is a private blog, but it is a very rich source of information about methylation, nutrigenomics and dietary supplementation

Here is a copy of the post:

"Common Terminology:

Methyl group: A methyl group is simply a single carbon atom bonded to 3 hydrogen atoms (CH3).

Methylation: Transfer of methyl groups from one chemical to another is called methylation. Essentially any chemical compound that has a methyl group as part of its chemical ... ..more

VDR
Vitamin D Receptor “Determines donors”

VDR Taq tt = -/- (green, no defect) tolerates fewer methyl donors
VDR Taq TT = +/+ (red, complete defect) tolerates more methyl donors
Partial or complete defects may mean you will not readily absorb Vit D from sun exposure. This may also contribute to seasonal depression, particularly when the sun is at it's lowest in the fall/winter season. Many studies in the past decade have noted a strong correlation between Vitamin D deficiency and neurological degeneration. In fact, aside from having implications in Parkinson’s and dementia, this SNP is highly associated with Multiple Sclerosis ... ..more

Annonymous

What are Sulfur & Thiols

  4 years, 1 month ago

Andy Cutler informs us that many mercury toxic people are intolerant to certain #foods , commonly known as ‘sulfur foods’, which have a high free thiol content. Consuming foods high in thiols raises the circulating thiol levels that in turn mobilizes #mercury and creates symptoms. He notes, “You typically get a couple of hours of feeling good, energized, happy, and then libidinous, then you feel tired, draggy and depressed, which goes on for a day to a week. Of course if you are eating sulfur foods at each meal these all get stacked up and you can never figure out what ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more


It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.

Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more

From Dr Ben:
In general, those with C677T mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity. Recommendations below support the reduction of these issues by increasing the body’s inherent ability to restore function through nutritional biochemistry.
Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.
Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.
Avoid folic acid blocking drugs such as birth control or Methotrexate.
Avoid drugs which increase ... ..more

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Annonymous

What is Norepinephrine

  4 years, 1 month ago

#Norepinephrine:
Think “nervous, nimble and nightmares” with Nor-epi. This is due to nor-epinephrine’s #adrenalin effects on the body as the main “fight or flight” #neurotransmitter . It’s essential for action in order to ward off attackers and initiate battle or escape. When we encounter something frightening, such as the sound of someone in your house at 3am, your nervous system releases nor-epinephrine. Once tired, you’ll suddenly feel the need to spring into action! Your heart starts to pound and hearing and vision become extremely acute while muscles tighten for attack. Unless you panic, you’ll also have clearer ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Annonymous

Any idea what Methyl Donors are ?

  4 years, 1 month ago

Limit with COMT+/+ or VDR -/-
Unless you are consuming an excessive amount, there is really no need to limit natural foods with methyl or sulfur donors.
Foods: Eggs, Spinach, Kale, & Caffeine—Tea, Coffee, Chocolate
MSM
Melatonin CoQ-10/Idebenone
Carnitine
Theanine
SAMe
Methyl B-12
Curcumin
Quercetin
DMG
TMG
Folapro
Metafolin
Deplin (5-MTHF)
#MethylDonors #Methylation #Supplements ..more