The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.
Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more
#Excitotoxins excite the nerve or brain cell to death.
MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more
Leaky Gut Syndrome affects millions of people worldwide. While some people show antibodies in their blood indicating an immune system response to the presence of various foods, others merely show signs and symptoms of sensitivity and intolerance. Both of these conditions, and many more, are indicators of leaky gut syndrome.
WHAT IS LEAKY GUT?
Leaky gut syndrome is an un-fancy name given to increased or excessive intestinal permeability. Essentially, the walls of our digestive tracts are compromised - more porous than is healthy and normal, and as a result, particles of food, toxins, bacteria and viruses all “leak” into the bloodstream ... ..more
￼￼￼￼￼￼￼￼￼￼￼What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.
2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, #sinusitus , #asthma , or #eczema . Polymorphisms in this #gene are also ... ..more
#Histamine is most commonly known for it's role in #allergic reactions but it is also involved in other neurological functions and can affect your #emotions as well as behavior. Histamine helps control the #sleep -wake cycle and promotes the release of epinephrine and #norepinephrine . This may be the explanation for red ears and #flushed cheeks in susceptible children and adults with high histamine levels.
High levels have been linked to obsessive-compulsive ( #OCD ) tendencies, #depression , and #headaches . Low levels can contribute to #paranoia , low #libido , #fatigue , and multiple medication sensitivities.
it is important to consider that those with the #CBS ... ..more
As far as I know the MTHFR mutations can affect the proper function of the immune system, and allergies are a result of immune system dysfunction.
PICTURE: Allergic orbital edema and conjunctivitis
From Dr. Carol Savage
I do not know all the ways that the Methyltetrahydrofolate Reductase [MTHFR] enzyme can weaken the immune system, but I do know that if we do not have enough SAMe then we cannot deactivate Histamine via the Histamine N-MethylTransferase [HNMT] enzyme.
If Histamine cannot be inactivated then the symptoms of excess HISTAMINE will be perpetuated.
#Homozygous #MTHFR #Heterozygous #health #Livewello #23andMe #SNPs #Genes #Methylation ... ..more
From Dr Carol Savage:
DIAMINE OXIDASE [DAO]…HISTAMINE
Histamine is a very important molecule for the human body because it fulfils many vital functions, but too much is not good. Histamine is both produced in the body and taken in with the ingestion of various foods.
Problems develop when there is an EXCESSIVE amount of HISTAMINE or when it is not adequately degraded. In either case histamine will lead to allergic or “Pseudo-allergic Reactions” [reactions that appear to be allergic in nature but are not].
S-Adenyl Methionine [SAMe] is needed to inactivate histamine in ... ..more