*Circulatory & blood clotting factors
*DNA synthesis & repair via thymidine synthesis
*Gene expression via epigenetic regulations such as histone modification
*Nitric oxide synthesis, aka blood vessel elasticity
*Removal of homocysteine, a potentially toxic and atherogenic amino acid
*Synthesis of powerhouse antioxidants such as Glutathione & SOD
*Neurotransmitter synthesis & degradation - dopamine, serotonin, norepinephrine, glutamate, GABA
*Biotransformation (aka “metabolism & detoxification”) of chemicals, carcinogens & drugs
*Synthesis of immune cells
*B-12 & Folate utilization
*Organ, tissue and fetal development
While their program is expensive it does seem like it would really make one a kind of expert.
Now if I could just find common, insured tests for ... ..more
I found this excellent description in Amy Yasko's forum: ch3nutrigenomics.com. It was posted by one of the members on the site- raji: http://www.ch3nutrigenomics...
This is a private blog, but it is a very rich source of information about methylation, nutrigenomics and dietary supplementation
Here is a copy of the post:
Methyl group: A methyl group is simply a single carbon atom bonded to 3 hydrogen atoms (CH3).
Methylation: Transfer of methyl groups from one chemical to another is called methylation. Essentially any chemical compound that has a methyl group as part of its chemical ... ..more
Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more
The Urea Cycle filters & processes toxic waste. Makes nitric oxide to limit free radical injury & maintains open & clean blood vessels to protect the heart & brain.
#NitricOxide #UreaCycle #Methylation ..more
#bloodsugar #diabetes diet #glaucoma #glucose #insulin #vitaminc
Diabetes and Glaucoma: A New Perspective
A study at the University of Michigan found people with diabetes have a 35% higher chance of having Glaucoma than people who do not. The study went on to say the reason for the higher rates of glaucoma in diabetics is “unknown.” My purpose for writing this article is to explain the nutritional reasons that diabetes and glaucoma often go hand in hand.
Before going further, let me state this very clearly: The purpose of this article is to provide education. Both diabetes and glaucoma are serious ... ..more
STEP ONE: Layering in The Foundation
Knowing your Nervous system #dominance is an integral part in establishing the treatment process.
A). Remove or limit triggers:
Processed foods contain excitotoxins, dyes, and #toxic preservatives. It is also crucial to remove obvious food #allergies . Please see Resqua pages on #excitotoxins for more information. This is simply defined and discussed in detail.
B). Begin general support:
Provide a good foundation for your nervous system type and begin nutritional support. Though life threatening reactions would be extremely rare (and to my knowledge, unheard of), moving too quickly can result in more intense symptoms of ... ..more
Although every living being requires oxygen for survival, oxygen is actually highly reactive and can damage living organisms by producing reactive oxygen species. In people, these unstable oxygen molecules occur with everyday living, during the normal breakdown of food or even as the #immune system is activated to fight off #bacteria & #virus. Other exposures include: smoking, using drugs or drinking too much alcohol, eating fried foods and refined sugars, air & water pollution, consuming #excitotoxins (MSG), dyes, toxic preservatives, and pesticides, as well as countless other contaminants that lead to widespread free radical damage, particularly once the body’s natural #antioxidants ... ..more
We frequently hear terms such as free radicals, #oxidative stress, and #antioxidants yet what exactly do these mean? Normally, a healthy cell has paired electrons—one that is positive and another that is negative.
Free radicals are molecules without positive electrons and are created whenever there is oxidation, AKA oxidative stress. This is really just a normal part of the everyday fallout of metabolism and by itself, isn’t necessarily a bad thing. Nonetheless, a city overwrought by criminals easily overwhelms the honest and industrious residents. Soon enough, the best and brightest citizens flee to the suburbs while this once ... ..more
It is best to use a “masticator” such as the Champion juicer, or a “twin press” juicer such as the Green Star Elite, rather than a “centrifugal” juicer. The latter adds oxygen to the juice’s enzymes during the process and this leads to “oxidation” or breakdown of nutrients.
While there are some exceptional products on the market, they can also be cumbersome and expensive (Norwalk $2800). In an ideal world, the GreenStar Elite (GSE) 5000 offers the best of both worlds and is actually a good compromise from Norwalk (yet much more costly than the Champion) at $550. Twin ... ..more
CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Dr. Yasko considers addressing CBS mutations as first priority aside from addressing the gut.
This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.
CBS defects are actually upregulations. This means the enzyme works too fast. Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia.
The upregulation ... ..more
Evaluating the nervous system’s style or “dominance” is a key factor in the initial process i.e dopamine or seratonin dominance. This will allow for a more targeted regimen, based on your individual needs. This is why consulting with your Doctor is pivotal.
1. Slowly adding basic supplements & support: general minerals, vitamin B’s & B-12, digestive enzymes, probiotics, antioxidants, essential fatty acids, etc.
2. Gut Health is critical. Since most chronically ill adults & children have at least 1-2 (if not 3-4!) enzyme defects that affect the gut and digestion, the gut is always a factor. Gut bugs tend to ... ..more
CBS C699T cystathionine beta synthase AKA The Hole in the Bucket. This Priority # 3 Mutation
Tip! It is crucial to address any gut issues before you thoroughly address the CBS defect. Since chronic gut issues lead to higher bacterial loads, thus leading to higher ammonia production as well as leaky gut (reducing nutrient absorption and increased risk for food sensitivity) this area is paramount. You can begin to address the CBS prior to fully addressing gut issues though they should be done in concert. Since the CBS is one of the most important issues to address, I’ve decided to ... ..more
Details of Liver Functions
The liver has a number of important functions, some of the main ones being:
Detoxification of potentially toxic chemicals from both inside and outside of the body including
drugs, alcohol and toxins from intestinal microbes. Accomplished with antioxidant nutrients
and enzymes such as glutathione. The liver detoxifies these harmful substances by a complex series of chemical reactions. The role of these various enzyme activities in the liver is to convert fat soluble toxins into water soluble substances that can be excreted in the
urine or the bile depending on the particular characteristics of ... ..more
1) Let's treat all this stuff now! By and large, #supplements are probably some of the safest treatments you will ever find, particularly when one considers the side effects associated with most prescription medicines. However, every single thing that you take has benefits and drawbacks. Simply stated, this means that supplements should be treated as medication. When you consider that many of the #methylation defects require any number of vitamins, enzymes, and co-factors to work more efficiently, these replacements have a crucial purpose. Since #methylation is instrumental in so many reactions, from proper #immune system function and making new ... ..more