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What is APOE?

  4 years, 5 months ago

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The #APOE #gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in #apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma #cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by ... ..more