Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS
Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more
8 Factors that Affect Your Methylation Process
--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine
--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more
Summary of analogies used in methylation community: CEOs: Directs each corporation in organized steps
Supervisors: Enzymes such as MTHFRs, COMT, SHMT, and BHMT
Enzymes are proteins that are produced by living cells and regulate the body’s process to breakdown products, such as ammonia.
Employees: Chemicals, proteins, DNA, etc.
Work tags: Methyl groups (Homocysteine, SAM, Methionine) The Chain Gang: Homocysteine (HCY)
Synopsis of the Cycles
1). Power Plant = Citric Acid Cycle =
Formerly known as the Kreb’s cycle) Recognized as the mitochondrial or energy cycle
2). Garbage Dump (& Recycling) =
The urea cycle, ammonia cleanup & nitric oxide production (heart/blood vessel protection)
3). Better Health 4 Life Corp (BH4) = Communications “AT&T” & toxic waste cleanup Neurotalkers: Dopamine, Serotonin, & Norepi
4). SAM’s Corp. = Methionine Cycle =
The major producer of methyl donors and the passageway to the garbage dump (NOS) & liver via the CBS enzyme
5). Farmer Folate = Folate Cycle =
Homegrown” RNA & DNA, methyl groups and Homocysteine (HCY) regulation
The Meaning of Methylation
Methylation is truly a multi-tasking marvel that allows us to be “healthy and human.” Though this highly intricate process occurs within each cell as well as in the fluid supplying the brain and within the liver, it is responsible for the most vital undertakings throughout body chemistry. Methylation determines who we are, what we look like, and how we behave and it is central to our physical, emotional, and mental wellbeing. Without methylation, we could not survive; hence, it is the perfect pathway to focus on for understanding autoimmune ... ..more
Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more
VITAMIN D Receptor BSM Single Nucleotide Polymorphism [SNP] and AUTOIMMUNE DISEASE
PICTURE: Vitamin D Receptor BSM1 [A60890G]
Most doctors don't check for Vitamin D 1,25 because it’s half-life is so very short and the doctors were generally taught in medical school not to bother checking Vitamin D1,25 levels.
People with the Vitamin D Receptor mutations called VDR BSM end up readily converting their vitamin D to D1,25 and meanwhile their Total Vitamin D 25 appears to be low [because it is all getting converted to D 1,25, and their doctors aren’t checking their ... ..more
HISTAMINE AND THE GUT By Carol Savage M.D.
Diamine Oxidase (DAO) is the enzyme in the gut responsible for the degradation of HISTAMINE.
Histamine N-MethylTransferase [HNMT] is an enzyme found inside cells so it breaks down histamine within cells. Diamine Oxidase [DAO] is likely “responsible for scavenging extracellular histamine after mediator release.”
Although Diamine Oxidase [DAO] is found everywhere in the body, the bowels are perhaps the most important site of the action of the enzyme DAO.
DAO is synthesized by mature and undamaged enterocytes [gut cells] in the small bowel, so any gut damage would decrease DAO release ... ..more
STEP ONE: Layering in The Foundation
Knowing your Nervous system #dominance is an integral part in establishing the treatment process.
A). Remove or limit triggers:
Processed foods contain excitotoxins, dyes, and #toxic preservatives. It is also crucial to remove obvious food #allergies . Please see Resqua pages on #excitotoxins for more information. This is simply defined and discussed in detail.
B). Begin general support:
Provide a good foundation for your nervous system type and begin nutritional support. Though life threatening reactions would be extremely rare (and to my knowledge, unheard of), moving too quickly can result in more intense symptoms of ... ..more
￼￼￼￼￼￼￼￼￼￼￼What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.
2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more
"Adrenal Fatigue" is a term that you hear a lot in the health community, but what is it exactly? In this article you'll learn the causes of adrenal fatigue, how it can impact how you feel, and what you can do about it!
Your adrenal glands sit on top of your kidneys and regulate many critical hormonal jobs in your body. One of those jobs is the secretion of your body's main stress hormone, cortisol. Our bodies have been designed for stressful events, and throughout time they have adapted to them. If our ancestors were chased by a ... ..more
1). #MTHFR #A1298C + #Liver & #BH4 support
Start at a few crumbs per day and very gradually, go up over several weeks’ time (generally 4-6 weeks). The goal is 1⁄2 to 1 capsule daily ($54.95/60 caps & $29.95/30 caps). This is whether you have the MTHFR A1298C defect or not.
2). Black Bear Spray or Get B12 Spray
Start at 1-2 sprays per day and very gradually work up to 3-5 sprays once or twice daily. A tip for adults who develop headaches with wine, it is very likely that you are sensitive to sulfites and the ... ..more
These days we don’t live in cabins on the remote Alaskan tundra so you can only do the best you can with the time and resources you have available. Take it one step at a time, and remember that this isn’t just about chronic neurological and autoimmune illness; it affects everyone. Work toward gradual changes and look for suitable alternatives, as even mild improvements can make a significant difference in health.
Remember that this is not an all or nothing lifestyle change. Gradually remove & replace what you reasonably can. If you can eliminate 40-50% of these toxins, you have made substantial progress toward lifelong neurological health.
There is no need to memorize all of the names for MSG. A good rule of thumb is if it takes you more than 1-2 minutes to read the ingredient list, it has too many #excitotoxins .
Make an #MSG limit & stick with it. Most GF/CF crackers or cookies have at least 3 to 5 hidden chemicals while the majority has 5 to 10, this is what makes them taste good.
A box of Hamburger Helper, RiceaRoni or a can of Campbell’s soup has at least 10 to 20 toxic ingredients. Try to limit each product to 5 or less and avoid having more than a few of these foodstuffs mixed in with homemade meals per day.
Remember, there is almost always a reasonable substitute for favorites. It is also important to realize that your taste buds will adapt once accustomed to less MSG.
Compromise to reduce your overall level.
For example, roasted peanut butter is more convenient & flavorful yet higher in glutamates than raw nut butter. Consider mixing 1⁄2 roasted nut butter with 1⁄2 raw nut butter to cut down on content and retain flavor.
Make up enormous batches of meatballs & patties, seasoned taco meat, stuffed meatloaf, chicken soup, chili, whole grain rice, sandwiches, stirfry, sausages, GF/CF pancakes & waffles, etc., and freeze them in meal size batches for busy nights & mornings. It’s much easier to reheat food in a toaster oven than to cook an entire meal three times a day.
If you occasionally eat fast food, limit the burger to “*protein style” with some plain fries. *This is without the bun.
Don’t forget that anything that is so delicious you just can’t stop eating it or often crave it is undoubtedly chock full of excitotoxins, which are triggering the addiction pathway.
Whenever possible, avoid any processed dipping sauces, soy sauce, soups, gravy, Worcester sauce, and many (not all) salad dressings as well as powder packs in foods such as Top Ramen, mac & cheese, bouillon, Accent, taco & other seasoning packs, etc.
Remember, life is short so it’s a compromise; when you really enjoy something and can’t make or find a good substitute ... ..more
The following are the most important issues to address as soon as you can:
Dietary changes: Reducing neurological irritation and achieving Glutamate #GABA balance is critical!
1). Excitotoxins: The more excitotoxins you have coming into your body will only serve to undo many of the helpful measures you’ve already implemented as well as those below. Therefore, I highly recommend a gluten (wheat, rye, barley), casein (*dairy), & soy free diet. See the attached sheets/PDF regarding dietary guidance. In the end, you can only do the best that you can so if finances do not permit this, simply avoid these ... ..more
1) Biopterin/Neopterin: For those with A1298C mutations, #BH4 (also known as tetrahydrobiopterin) levels are typically quite low. This test provides insight to how low these levels are and why. If neopterin levels are high, then I am considering the possibility of a lingering infection, inflammation or chronic immune response that is preventing #biopterin from being formed. Thus, this test provides information not only potentially low biopterin levels but also why they may be low.
If a doctor simply prescribes BH4 without understanding the need to address the inflammation and chronic infections, it is band-aide treatment over a gaping wound ... ..more
The methylation pathway can be likened to the body’s chief housekeeping and maintenance systems. It is responsible for many of the most complex and vital undertakings throughout the body, occurring each time the body takes one substance and turns it into another. This chemical exchange occurs between enzymes, amino acids, proteins, and other molecules in order to maintain cell function. Methylation regulates gene expression, allowing beneficial genes to function while keeping less desirable genes at bay. It also provides the backbone for the immune system, DNA, RNA, cellular repair, detoxification, hormone regulation, and communication between the cells and ... ..more
Understandably, human beings adapt much more readily to positive reinforcement, avoiding the negative experiences. While there are many approaches to #detox , experience has shown that it takes commitment on par with taking a seminar or, when really ill, getting through a longer flu or hospitalization. It takes an extensive amount of time, energy, and dedication, which is often extremely difficult for those who work full-time and/or have a difficult time slowing down. Regardless of the strategy, if you relegate the process to moments of “when I get time,” you cannot be successful. Many make the mistake of trying to ... ..more
The human genome is a string of over 3 billion chemical letters that spell out every inherited trait. Although the letters of all our genomes are virtually identical and have little variation, more and more frequently, nature gets a letter wrong, similar to a typo. Scientists call these genetic misspellings SNPs (Pronounced: snips), or single nucleotide polymorphisms, which occur as variations at a single site in DNA. In fact, a SNP is the most frequent variation in the human genome with about 5-10 million of them. Although not all of these disparities contribute to disease. Scientists are now using them ... ..more