1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.
How does the Livewello App work with your Genetic Raw Data?
2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more
You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More
6 Ways A DNA Test Can Help You Optimize Your Diet
Matching Genes and Vitamins. A Personalized Plan May Be in Your Future
Why would you need to run a Genetics test?
LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!
b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas
DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more
A Standard Gene Report with information looks like this: https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.
1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more
It produces a defective MTHFR enzyme of different varieties i.e. it functions less than optimally, such as performing at only 40% of its capacity, or 70% of its capacity. It can mean you won’t break down toxins or heavy metals well i.e. you could find yourself with high iron, or high copper, or high mercury….etc. High copper can also cause low iron.
The defective enzyme doesn’t break down folate vitamins properly (of which folic acid is the precursor to), which can cause high homocysteine, which can increase your risk of coronary heart disease (arteriosclerotic vascular ... ..more
What does it mean to "spare dopamine"? As mentioned in the above COMT discussion. Not use it? Not create it? ..more
Methylenetetrahydrofolate reductase (MTHFR) supports one's health, well-being and detoxification and can be defective in a fairly large percentage of our population. About 45% of Caucasians, 70% of Hispanics and about 30% of southern Italians have a genetic defect.
The MTHFR gene produces the MTHFR enzyme. This enzyme is responsible for the circulating form of folate. Folate is very important in homocysteine regulation. The MTHFR enzyme metabolizes folic acid into 5-MTHF, which is needed to combine with homocysteine to break it down and to facilitate methylation (detoxification) processes in the body. The MTHFR enzyme is essential for the body to ... ..more
￼￼￼￼￼￼￼￼￼￼￼What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.
2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more
A chemical made in the BH4 cycle, which is used to produce dopamine and serotonin, neurotransmitters strategic in regulating mood, sleep, attention and focus, reward seeking behavior, addiction, and sense of wellbeing. BH4 is also critical in the urea cycle (waste facility) for cleaning up ammonia and making nitric oxide. A shortage of this important chemical has widespread repercussions.
Tetrahydrobiopterin BH4 Cycle produces the BH4 used for making neuro-talkers (dopamine, epinephrine, nor-epi, serotonin, & melatonin). It cleans up toxic ammonia in The Waste Cycle & makes Nitric oxide to protect the heart & brain.
Though controversy exists regarding this cycle’s function, Dr. Yasko’s theory indicates that The Big Motherflipper (MTHFR A1298C) may drive this cycle in the reverse direction and several independent studies support this finding. This leads to a chemical exchange among BH2 to BH4, a multi-purpose product that is used in both the Waste Facility (urea cycle) and BH4 Industry. Within the Better Health 4 Life Industry, BH4 produces chemicals known as neurotransmitters, or neurotalkers (NTs), including dopamine, serotonin, melatonin, norepinephrine, and epinephrine. NTs are central for the communication between nerves and cells as well as stabilizing the crisis response, mood, and sleep cycles. Chronically low BH4 levels increase the risk for ADD/ADHD, Bipolar Disorder, OCD, insomnia, depression, anxiety, and many other quality of life issues. Think of this company as AT&T with a philanthropic twist since it donates BH4 to the Waste Facility for environmental clean up as well as supporting the community in health & wellbeing.
The Waste Facility uses BH4 to clean up toxic ammonia and generates nitric oxide, an element that keeps blood vessels open and free of plaque. Yet if BH4 is scarce, it cannot clean up waste or deliver vital nutrients to the Power Plant (fumarate) so that noxious chemicals back up into SAM’s Corporation. Given the fact that it takes 2 grains of BH4 to clean up 1 granule of ammonia, as well as 2 of BH4 to create just 1 bit of nitric oxide, its easy to see how problems might arise. This underscores the BH4 Industry’s role throughout the community since unlike an actual factory; it isn’t permitted to shut down for repairs or maintenance.
While there are many factors that may impact this cycle, several are listed below:
1. A ... ..more
To learn more about COMT Gene:
Dr. Richard Deth PhD
Dr. Jill James PhD
1) http://www.ucdmc.ucdavis.ed... (2006 lectures, please scroll down for oxidative Stress Lecture as well).
2) http://www.ucdmc.ucdavis.ed... (2010 Lecture Methylation/Oxidative stress). http://www.youtube.com/watc...
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.
Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more
1) Biopterin/Neopterin: For those with A1298C mutations, #BH4 (also known as tetrahydrobiopterin) levels are typically quite low. This test provides insight to how low these levels are and why. If neopterin levels are high, then I am considering the possibility of a lingering infection, inflammation or chronic immune response that is preventing #biopterin from being formed. Thus, this test provides information not only potentially low biopterin levels but also why they may be low.
If a doctor simply prescribes BH4 without understanding the need to address the inflammation and chronic infections, it is band-aide treatment over a gaping wound ... ..more