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#23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more

#23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more

#23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ #OvarianCancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your #BRCA1 and #BRCA2 locations. Genotype DI ... ..more

Trying to find your results on the BRCA Genes tested on by 23andMe? Here's an easy way to check your BRCA1/BRC2 results:

 23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ Ovarian Cancer Syndrome. 

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are ... ..more

Annonymous

What is pharmacogenomics?

  3 years, 11 months ago

Pharmacogenomics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.

Many drugs that are currently available are “one size fits all,” but they don’t work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions ... ..more

Statistical data can provide general information about how common a condition is, how many people have the condition, or how likely it is that a person will develop the condition. Statistics are not personalized, however—they offer estimates based on groups of people. By taking into account a person’s family history, medical history, and other factors, a genetics professional can help interpret what statistics mean for a particular patient.

Some statistical terms are commonly used when describing genetic conditions and other disorders. These terms include:

Common statistical terms
Incidence
The incidence of a gene mutation or a genetic disorder ... ..more

A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a person’s genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent. These genetic changes contribute to the development of a disease but do not directly cause it. Some people with a predisposing genetic variation will never get the disease while others will, even within the same family.

Genetic variations can have large or small effects on the likelihood of developing a particular disease. For example, certain mutations in the BRCA1 or BRCA2 ... ..more

Mitochondria (illustration) are structures within cells that convert the energy from food into a form that cells can use. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA (known as mitochondrial DNA or mtDNA). In some cases, inherited changes in mitochondrial DNA can cause problems with growth, development, and function of the body’s systems. These mutations disrupt the mitochondria’s ability to generate energy efficiently for the cell.

Conditions caused by mutations in mitochondrial DNA often involve multiple organ systems. The effects of these conditions are most pronounced ... ..more

Changes that affect the structure of chromosomes can cause problems with growth, development, and function of the body’s systems. These changes can affect many genes along the chromosome and disrupt the proteins made from those genes.

Structural changes can occur during the formation of egg or sperm cells, in early fetal development, or in any cell after birth. Pieces of DNA can be rearranged within one chromosome or transferred between two or more chromosomes. The effects of structural changes depend on their size and location, and whether any genetic material is gained or lost. Some changes cause medical problems ... ..more

The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the B-vitamin folate (also called folic acid or vitamin B9). Specifically, this enzyme converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.
How are changes in the MTHFR gene related to health conditions?
homocystinuria - caused by mutations ... ..more

Methylation is a key biochemical process that is essential for the proper function of almost all of your body’s systems. It occurs billions of times every second; it helps repair your DNA on a daily basis; it controls homocysteine (an unhealthy compound that can damage blood vessels); it helps recycle molecules needed for detoxification; and it helps maintain mood and keep inflammation in check.

To keep methylation running smoothly you need optimal levels of B vitamins. Without enough B vitamins methylation breaks down, and the results can be catastrophic. In these cases we see more birth defects like spina ... ..more

Annonymous

What is Methylation?

  4 years ago

Methylation
The methylation pathway can be likened to the body’s chief housekeeping and maintenance systems. It is responsible for many of the most complex and vital undertakings throughout the body, occurring each time the body takes one substance and turns it into another. This chemical exchange occurs between enzymes, amino acids, proteins, and other molecules in order to maintain cell function. Methylation regulates gene expression, allowing beneficial genes to function while keeping less desirable genes at bay. It also provides the backbone for the immune system, DNA, RNA, cellular repair, detoxification, hormone regulation, and communication between the cells and ... ..more

YouTube

8 Factors that Affect Your Methylation Process

--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine

--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more

23andme currently only tests for THREE mutations in these genes. So, even if 23andme says you are normal for all three mutations, you could still have a harmful mutation somewhere else in one of these genes. Any harmful mutation means a person has Hereditary Breast/ Ovarian Cancer Syndrome.

The three mutations 23andme tests for are found mostly in Ashkenazi (Eastern European) Jews. It just happens that these three mutations are easy to test for and are well-studied.

As a general rule, you are hoping NOT to see DI as the genotype at any of your BRCA1/BRCA2 locations. Genotype DI ... ..more

5 “Healthy” Foods That Aren’t
January 15, 2014 by Erin Ter Beest

In a world of competing health claims, it’s hard to know what foods are really nourishing and health-promoting. Sometimes it’s even hard to tell whether or not something is really food or just a “food-like substance!” While the occasional #junk food isn’t going to kill you (and stressing out about completely avoiding it might actually do more damage than the occasional junk food itself), there are many “health” foods that have made their way into our diets regularly that are doing serious damage to ... ..more


Summary of analogies used in methylation community: CEOs: Directs each corporation in organized steps
Supervisors: Enzymes such as MTHFRs, COMT, SHMT, and BHMT
Enzymes are proteins that are produced by living cells and regulate the body’s process to breakdown products, such as ammonia.
Employees: Chemicals, proteins, DNA, etc.
Work tags: Methyl groups (Homocysteine, SAM, Methionine) The Chain Gang: Homocysteine (HCY)
Synopsis of the Cycles
1). Power Plant = Citric Acid Cycle =
Formerly known as the Kreb’s cycle) Recognized as the mitochondrial or energy cycle
2). Garbage Dump (& Recycling) =
The urea cycle, ammonia cleanup & nitric oxide production (heart/blood vessel protection)
3). Better Health 4 Life Corp (BH4) = Communications “AT&T” & toxic waste cleanup Neurotalkers: Dopamine, Serotonin, & Norepi

4). SAM’s Corp. = Methionine Cycle =
The major producer of methyl donors and the passageway to the garbage dump (NOS) & liver via the CBS enzyme
5). Farmer Folate = Folate Cycle =
Homegrown” RNA & DNA, methyl groups and Homocysteine (HCY) regulation

The Meaning of Methylation
Methylation is truly a multi-tasking marvel that allows us to be “healthy and human.” Though this highly intricate process occurs within each cell as well as in the fluid supplying the brain and within the liver, it is responsible for the most vital undertakings throughout body chemistry. Methylation determines who we are, what we look like, and how we behave and it is central to our physical, emotional, and mental wellbeing. Without methylation, we could not survive; hence, it is the perfect pathway to focus on for understanding autoimmune ... ..more

The conventional cleaning industry has so many dirty little secrets. Here are a few of the big ones that you need to know before you use these products in your home.

1. Ingredients are privileged information.

About 70% of adults believe that companies are required to disclose all of the chemical ingredients contained in their products, which isn’t true. Manufacturers are only required to list the ingredients that are active disinfectants (because these are technically pesticides) or known to be acutely hazardous (which to them includes ingredients that cause fires or explosions, but not those that cause cancer or ... ..more

VITAMIN D Receptor BSM Single Nucleotide Polymorphism [SNP] and AUTOIMMUNE DISEASE

PICTURE: Vitamin D Receptor BSM1 [A60890G]

Most doctors don't check for Vitamin D 1,25 because it’s half-life is so very short and the doctors were generally taught in medical school not to bother checking Vitamin D1,25 levels.

People with the Vitamin D Receptor mutations called VDR BSM end up readily converting their vitamin D to D1,25 and meanwhile their Total Vitamin D 25 appears to be low [because it is all getting converted to D 1,25, and their doctors aren’t checking their ... ..more

There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?

I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.

The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more

Annonymous

What does Methylation do?

  4 years, 3 months ago

The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.

Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more