Introduction to The Vagus Nerve
In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.
The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.
The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more
Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS
Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more
You have been diagnosed with a chronic health condition. Your genetic information will help you determine which genes or biochemical pathways were altered to result in that health condition. Getting to the root cause, will help facilitate recovery by tailoring any treatment plans and lifestyle changes your Doctor recommends specifically to your body.
Several members of your family live with one or several chronic health issues. Genetic information will help your family uncover the inherited Gene sequence patterns that contribute to the chronic illnesses plaguing them.
You plan to have a baby: Research is implicating certain genetic mutations in a ... ..more
Genome-wide association studies are a relatively new way for scientists to identify genes involved in human disease. This method searches the genome for small variations, called single nucleotide polymorphisms or SNPs (pronounced “snips”), that occur more frequently in people with a particular disease than in people without the disease. Each study can look at hundreds or thousands of SNPs at the same time. Researchers use data from this type of study to pinpoint genes that may contribute to a person’s risk of developing a certain disease.
Because genome-wide association studies examine SNPs across the genome, they represent a promising ... ..more
By Helen Janneson Bense
A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.
Functions of BH4
Cofactor for all three isotypes of nitric ... ..more
1) You have been diagnosed with a chronic health condition.
Your genetic information will help you determine which genes or biochemical pathways altered to result in that health condition. Getting to the root cause, will help facilitate recovery by tailoring any treatment plans and lifestyle changes your Doctor recommends specifically to your body.
2) Several members of your family live with one or several chronic health issues.
Genetic information will help your family uncover the inherited Gene sequence patterns that contribute to the chronic illnesses plaguing them.
3) You plan to have a baby.
Research is implicating certain genetic mutations ... ..more
Lab Tests indicating a need to address Bacterial Imbalances:
History of chronic #ear infections
Maternal history of #Streptococcal infection
History of bacterial #pneumonia
Streptococcus, E coli on #CSA / #GI Profile
Other #bacterial #pathogens on CSA/GI Profile
Elevated kynurenic on #OAT / #Metabolic Test, CONFIRM with CSA/GI Profile
Elevated quinolinic on OAT/Metabolic Test, CONFIRM with CSA/GI Profile
Low gut #pH or high gut pH
High suberic on a #MAP or #OAT
High DHPPA on a MAP or OAT
#Supplements to balance / repopulate GI tract/ decrease E.coli and Strep:
Bowel Support Formula RNA
Special digestive enzymes
VDR Fok ... ..more
5 “Healthy” Foods That Aren’t
January 15, 2014 by Erin Ter Beest
In a world of competing health claims, it’s hard to know what foods are really nourishing and health-promoting. Sometimes it’s even hard to tell whether or not something is really food or just a “food-like substance!” While the occasional #junk food isn’t going to kill you (and stressing out about completely avoiding it might actually do more damage than the occasional junk food itself), there are many “health” foods that have made their way into our diets regularly that are doing serious damage to ... ..more
Summary of analogies used in methylation community: CEOs: Directs each corporation in organized steps
Supervisors: Enzymes such as MTHFRs, COMT, SHMT, and BHMT
Enzymes are proteins that are produced by living cells and regulate the body’s process to breakdown products, such as ammonia.
Employees: Chemicals, proteins, DNA, etc.
Work tags: Methyl groups (Homocysteine, SAM, Methionine) The Chain Gang: Homocysteine (HCY)
Synopsis of the Cycles
1). Power Plant = Citric Acid Cycle =
Formerly known as the Kreb’s cycle) Recognized as the mitochondrial or energy cycle
2). Garbage Dump (& Recycling) =
The urea cycle, ammonia cleanup & nitric oxide production (heart/blood vessel protection)
3). Better Health 4 Life Corp (BH4) = Communications “AT&T” & toxic waste cleanup Neurotalkers: Dopamine, Serotonin, & Norepi
4). SAM’s Corp. = Methionine Cycle =
The major producer of methyl donors and the passageway to the garbage dump (NOS) & liver via the CBS enzyme
5). Farmer Folate = Folate Cycle =
Homegrown” RNA & DNA, methyl groups and Homocysteine (HCY) regulation
The Meaning of Methylation
Methylation is truly a multi-tasking marvel that allows us to be “healthy and human.” Though this highly intricate process occurs within each cell as well as in the fluid supplying the brain and within the liver, it is responsible for the most vital undertakings throughout body chemistry. Methylation determines who we are, what we look like, and how we behave and it is central to our physical, emotional, and mental wellbeing. Without methylation, we could not survive; hence, it is the perfect pathway to focus on for understanding autoimmune ... ..more
The Citric Acid Cycle AKA “The Power Company” is essential for processing and converting all dietary nutrients (vitamins, minerals, fats, amino acids) into useable forms of energy just as any power industry processes coal, gas, or oil for energy production. If you visualize this cycle as a clock, each hour represents an area in which one nutrient converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within this clock. This may lead to significant metabolic (chemical processing) imbalances within ... ..more
Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more
It’s important to determine which treatments are temporary and only required for initial support and healing vs. those which are essential for life long health and well-being. Many of these will correlate with complete blocks, or full typos in your genetic code while some may be vital supports for partial blocks that lead to substantial illness or disability. Most will require anywhere from 10-15 nutrients for maintenance. Still, some will be indispensable, others will no longer be vital, and many others will only be needed as issues arise.
B). Nerve Repair: Depending on your health problems, this is the ... ..more
There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?
I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.
The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more
The Methionine Cycle is the major work tag (methyl donor) manufacturer. SAMe has over 400 functions in the community. Also serves as the main route through to liver & Waste cycle.
Methionine (SAM) Cycle AKA “SAM’s Corporation,” As SAMe has over 400 known methylation reactions, SAM’s Corporation is the chief work tag producer. It’s also where most of the action occurs since it contains the major thoroughfare to the liver (CBS & transsulfuration). While this often works to its’ advantage, it can also pose a safety risk since failure along this route may result in calamity (see Waste Facility ... ..more
These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle
( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility ... ..more
#Parasympathetic Nervous System “Rest, repair, & digest” or “Type B’s” There are 3 basic #PNS Dominant subtypes: Basic, Extreme, & Inefficient PNS Dominant types.
The following is a summary of the average PNS Dominant type. The parasympathetic nervous system (PNS) works to nourish, heal and regenerate the body. It is anabolic, which means it is concerned with rebuilding the body and storing nutrients. Its’ nerves stimulate the immune system, digestion, and urinary function. These organs include the liver, pancreas, stomach, intestines, kidneys, and bladder.
The parasympathetic nervous system, when activated by rest, relaxation and positive thinking, is essential for the elimination of wastes, emotional wellbeing and healing. When you feel absolutely stuffed and lethargic after a big Thanksgiving dinner, it is your PNS that is most active. In situations in which we have excessive parasympathetic nervous system dominance, we often find #disorganization , #depression , #apathy , and #lethargy . There may also be a decrease in clarity of thought such as “spaciness” or poor concentration. The #adrenal and #thyroid glands tend to be underactive and sex #hormones such as #estrogen , #progesterone , and #testosterone are abnormally low. There are frequently issues with multiple #allergies and sensitivities #MCS , dry skin, weight gain or a tendency toward #obesity . These are generally the people who go on the same exact “Healthy” diet as their friends or partner yet struggle to lose a few pounds. Meanwhile, everyone one else has lost 10-20 lbs and is back to their regular routine.
Other signs and symptoms include: frequent hunger, dry/irritated eyes, unexplained sneezing or coughing, #asthma , dizziness (particularly with standing), irregular heart beats or “skipped heart beats”, low blood pressure, and #hypoglycemia as well as increased production of all digestive enzymes and bowel activity, leading to more “stomach rumbling”. #PNS Dominants rarely struggle with #constipation and may have periods of loose or frequent stools. They are also more likely to experience the feeling of being “Tired yet wired,” particularly after eating a simple carbohydrate or sugary snack.
While #SNS Dominants may also struggle with this tired yet wired sensation, it is usually more prominent in PNS Dominance. Incidentally, those who cannot tolerate higher altitudes or the more rapid drops in barometric pressure (weather changes) are more likely the PNS Dominant or “Inefficient Balanced” types as a stronger SNS is required in adjusting to higher altitudes and changing weather patterns. These are the folks who know the weather is going to change before anyone else and often suffer with allergies or headaches. They are also prone to upper #respiratory infections, which may evolve to #bronchitis or #pneumonia . Despite this, they do not tolerate hot weather as well as the other types and prefer colder climates. They are also prone to flushing and may have pinker or darker ears and a “ruddy” complexion.
Nevertheless, when these individuals are well, they can be highly creative and productive and are often slow to anger. They tend to have less interest in “left brain” academics (math or science) and often prefer “right brain” academics (art, music, & lit).
According to Dr. Gonzalez, many Nobel Prize winners in art and literature are PNS Dominants (Hemmingway, Faulkner, & Lewis). PNS Dominants typically avoid confrontational professions and enjoy those, which allow their heightened creative abilities to flourish. And, depending upon where they reside within the PNS axis, many are “foodies” who live to eat rather than simply eating to live, as SNS types tend to do. These folks typically enjoy discussing good restaurants or engaging in discussions about great meals and recipes. They typically gravitate toward meat & potatoes with some veggies usually the root (potatoes, squash, yams) or cruciferous veggies (broccoli, cauliflower, Brussel Sprouts, cabbage). In general, PNS Dominants are more sociable than SNS types. Likewise, they may prefer to remain busy yet tend to avoid exercise. Still, #genetic factors also considerably influence many of these traits.
Finally, PNS Dominants are most likely to develop immune related cancers such as malignant #melanoma , #lymphoma , #sarcoma , and #leukemia . Food priorities: It is generally helpful to evaluate the foods you crave and how you tolerate each newly introduced food. For instance, after eating meat do you feel better and more clearheaded or are you more anxious, jittery, or depressed? If you’re having a lot of digestive issues, you may want to begin with mostly cooked foods, at least to some degree, in order to reduce the strain on your digestive system. Therefore, it is important to consider whether or not you tolerate raw vs. cooked foods. Those with PNS Dominance favor butter, cream, meat, and potatoes as well as sour flavors. Yet they avoid sweets, although a heavier pastry with butter or cream is acceptable.
Regrettably, many PNS Dominants have been heavily influenced by medical and nutrition experts and eat well outside their nutritional requirements. They may favor heavier, “meat & potato” meals yet eat leaner meats, whole grain carbs, fruits, and vegetables despite not feeling satisfied. While many desire bacon and egg breakfasts, they opt for the lighter fruit, toast, and yogurt fare of the SNS Dominant, thinking this is a “healthier” choice. And, even while they gag at the thought of oatmeal or cream of wheat, they do their best to find a “healthy” compromise. They frequently have a spurt of energy for 30 minutes or so, only to feel tired and lackluster within the space of an hour. Yet, if allowed to eat a thick slice of ham with potatoes, they’ll have the energy they need to work throughout the entire morning.
In fact, many “vegetarian” PNS Dominants feel much more alert and energetic when they start eating animal proteins While they sought out the heavier “allowed” proteins (cheese, eggs, hummus), most never felt satiated. For the PNS Dominant, eating meat is not “morally inferior”; it is essential for their health and survival Ultimately, each person should consume the most healthful foods for their metabolic make up. Though SNS Dominants require mostly vegetarian, raw foods, for greatest health, those who are PNS Dominant require fattier, red meats. They are hardwired to function well on the wholesome, omega 3 fats & #glutamate found in grass fed meats. Besides, most will develop a multitude of health problems if they adopt the SNS Dominant’s diet. For those with concerns regarding #sulfur , while foods such as #broccoli & #cauliflower contain a fair amount of sulfur ... ..more