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*Circulatory & blood clotting factors
*DNA synthesis & repair via thymidine synthesis
*Gene expression via epigenetic regulations such as histone modification
*Nitric oxide synthesis, aka blood vessel elasticity
*Removal of homocysteine, a potentially toxic and atherogenic amino acid
*Synthesis of powerhouse antioxidants such as Glutathione & SOD
*Neurotransmitter synthesis & degradation - dopamine, serotonin, norepinephrine, glutamate, GABA
*Biotransformation (aka “metabolism & detoxification”) of chemicals, carcinogens & drugs
*Synthesis of immune cells
*B-12 & Folate utilization
*Organ, tissue and fetal development

While their program is expensive it does seem like it would really make one a kind of expert.

Now if I could just find common, insured tests for ... ..more

Annonymous

What is pharmacogenomics?

  4 years, 2 months ago

Pharmacogenomics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.

Many drugs that are currently available are “one size fits all,” but they don’t work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions ... ..more

Genome-wide association studies are a relatively new way for scientists to identify genes involved in human disease. This method searches the genome for small variations, called single nucleotide polymorphisms or SNPs (pronounced “snips”), that occur more frequently in people with a particular disease than in people without the disease. Each study can look at hundreds or thousands of SNPs at the same time. Researchers use data from this type of study to pinpoint genes that may contribute to a person’s risk of developing a certain disease.

Because genome-wide association studies examine SNPs across the genome, they represent a promising ... ..more

People have two copies of most genes, one copy inherited from each parent. In some cases, however, the number of copies varies—meaning that a person can be born with one, three, or more copies of particular genes. Less commonly, one or more genes may be entirely missing. This type of genetic difference is known as copy number variation (CNV).

Copy number variation results from insertions, deletions, and duplications of large segments of DNA. These segments are big enough to include whole genes. Variation in gene copy number can influence the activity of genes and ultimately affect many body functions ... ..more

8 Factors that Affect Your Methylation Process

--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine

--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more

SYMPTOMS OF TOO MUCH HISTAMINE
Histamine def:
“Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine is involved in the inflammatory response.” [wiki]

FOR MORE INFORMATION:

http://headacheandmigrainen...

After eating certain histamine aggravating foods or when there is an excessive quantity of released HISTAMINE in the body symptoms may include:
Arrhythmia
Asthma
Depression
Dizziness
Dry nose
Gastrointestinal complaints
Hypotension
Itchy skin
Menstrual pain [worse]
Migraine headache
Red skin
Rhinitis [vasomotor rhinitis]
Soft stools
Tachycardia
DIAMINE OXIDASE [DAO]
Reduced function of the enzyme Diamine ... ..more

Annonymous

What does Methylation do?

  4 years, 5 months ago

The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.

Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more

These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle
( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility ... ..more


By Caledonia
1-21-2014

ME/CFS patients are notoriously very sensitive to medicines and supplements. It’s common to have adverse reactions, or to only be able to tolerate small doses.
Newbies are especially prone to taking too large of doses or going too fast. The following explains how to manage such sensitivity.

Start Low and Go Slow

Whenever you start a new medicine or supplement, it is suggested to practice Start Low and Go Slow.

This means starting with very small doses, much less than a normal dose, such as 1/8 of pill. That way, if you're going ... ..more

YouTube

Annonymous

What are Free Radicals ?

  4 years, 5 months ago

Although every living being requires oxygen for survival, oxygen is actually highly reactive and can damage living organisms by producing reactive oxygen species. In people, these unstable oxygen molecules occur with everyday living, during the normal breakdown of food or even as the #immune system is activated to fight off #bacteria & #virus. Other exposures include: smoking, using drugs or drinking too much alcohol, eating fried foods and refined sugars, air & water pollution, consuming #excitotoxins (MSG), dyes, toxic preservatives, and pesticides, as well as countless other contaminants that lead to widespread free radical damage, particularly once the body’s natural #antioxidants ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

From Dr Ben:
In general, those with C677T mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity. Recommendations below support the reduction of these issues by increasing the body’s inherent ability to restore function through nutritional biochemistry.
Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.
Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.
Avoid folic acid blocking drugs such as birth control or Methotrexate.
Avoid drugs which increase ... ..more

Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting terms for a nutrient they really need.

Understanding which form of methylfolate is best must be clear.

Why all the confusion?

Because there are so many different terms used for methylfolate.

By the end, you will understand everything you need to know about methylfolate.

More significantly – you will understand how to pick the right form of methylfolate.

Terms often used for methylfolate are:

Methylfolate
L-MTHF
L-Methylfolate
L-Methylfolate Calcium
D-Methylfolate
D-5-Methylfolate
Levomefolic Acid
Metafolin
5-MTHF
5-Methylfolate
5-Methyltetrahydrofolate
L-5-MTHF
L-5-Methyltetrahydrofolate
6(S)-5-MTHF
6(S)-5-Methyltetrahydrofolate ... ..more

1). #MTHFR #A1298C + #Liver & #BH4 support
Start at a few crumbs per day and very gradually, go up over several weeks’ time (generally 4-6 weeks). The goal is 1⁄2 to 1 capsule daily ($54.95/60 caps & $29.95/30 caps). This is whether you have the MTHFR A1298C defect or not.

2). Black Bear Spray or Get B12 Spray
Start at 1-2 sprays per day and very gradually work up to 3-5 sprays once or twice daily. A tip for adults who develop headaches with wine, it is very likely that you are sensitive to sulfites and the ... ..more

Annonymous

What is Dopamine ?

  4 years, 5 months ago

Think “delightful dialogue” with #dopamine since this #neurotransmitter is crucial for happiness, a sense of wellbeing, and language. It’s also involved in #muscle control and function. Dopamine is responsible for #motivation , interest, #mood , #speech , and contentment. It is also associated with positive #stress states such as being in love, exercising, listening to music, and of course, #sex . When you don't have enough dopamine, you may have difficulty initiating or completing tasks. Deficiencies also lead to poor #concentration , little or no energy, and lack of motivation. This could be the culprit if you lack the initiative to study the ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Annonymous

How does HISTAMINE affect you?

  4 years, 5 months ago

#HISTAMINE RECEPTORS
http://healthypixels.com/wp...

Most of us know histamines through #antihistamine drugs that relieve our suffering from #allergies to pollen, insect bites, and even foods.
Histamine is naturally produced in our body by #mastcells or white blood cells.
Histamine performs different functions by binding with histamine receptors. Depending upon their location, histamine receptors control very different body functions:

Histamine #H1 receptors:
Smooth muscle and endothelial cells affecting skin; blood vessels (Benadryl and Claritin block activity of these receptors)

Histamine #H2 receptors:
Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate
(Histamine H2 receptor antagonist ... ..more

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http://balancedconcepts.net...
Details of Liver Functions
The liver has a number of important functions, some of the main ones being:

Detoxification of potentially toxic chemicals from both inside and outside of the body including
drugs, alcohol and toxins from intestinal microbes. Accomplished with antioxidant nutrients
and enzymes such as glutathione. The liver detoxifies these harmful substances by a complex series of chemical reactions. The role of these various enzyme activities in the liver is to convert fat soluble toxins into water soluble substances that can be excreted in the
urine or the bile depending on the particular characteristics of ... ..more

The human genome is a string of over 3 billion chemical letters that spell out every inherited trait. Although the letters of all our genomes are virtually identical and have little variation, more and more frequently, nature gets a letter wrong, similar to a typo. Scientists call these genetic misspellings SNPs (Pronounced: snips), or single nucleotide polymorphisms, which occur as variations at a single site in DNA. In fact, a SNP is the most frequent variation in the human genome with about 5-10 million of them. Although not all of these disparities contribute to disease. Scientists are now using them ... ..more