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It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.

Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more

#NMDA RECEPTORS
http://users.humboldt.edu/j...
Taking #Magnesium will help to block an otherwise over-active NMDA Receptors and… calm the brain.
HOMOCYSTEINE can occupy the #Glutamate Receptor on the NMDA Receptor and over stimulate the receptive dentritic neuron and can lead to neuronal damage or “burn out” [death].

Taking MAGNESIUM is calming because in part it blocks the NMDA Receptor and buffets the excessive stimulation by TOO MUCH HOMOCYSTEINE occupying the Glutamate Receptor site.
A synapse that is gated by only NMDA is less likely to cause an excitatory post synaptic potential (EPSP) because the ion channel is blocked ... ..more

Annonymous

What is Homocysteine ?

  4 years, 1 month ago

#Homocysteine is a toxic waste by-product of protein and amino acid metabolism, and #methylation in the body is going on constantly, converting this damaging homocysteine into the #antioxidant #glutathione.
Methylation also converts homocysteine into an important biochemical called #SAMe , a vital methyl donor for the production of the all important neurotransmitters dopamine, serotonin and their derivatives. This is how the body makes good use of this toxic element.

Keeping homocysteine at a healthy, low level is extremely important for keeping our risk of heart disease, stroke and Alzheimer's disease as low as possible. High levels of homocysteine, if left ... ..more

Annonymous

What is Glutamate ?

  4 years, 1 month ago

Glutamate is the major excitatory #neurotransmitter and the most commonly found NT in the brain. It is required for #learning and #memory , however, an excess of #glutamate is actually toxic to brain cells and nerves. #LouGehrig’s is the most well known disease of glutamate excess but newer evidence reveals many other disorders may be related such as #Autism , #CFS, many #seizure disorders, #Migraines , #MS , and many more. Glutamate balances #GABA ’s calming effect.
High levels can cause nerve and brain cell death and injury through inflammation. High or imbalanced glutamate levels are clearly involved in many neurological diseases such ... ..more