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What is MTHFR A1298C Gene Mutation ?

  3 years, 12 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

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Annonymous

What is Sympathetic Dominance

  4 years, 3 months ago

#Sympathetic Nervous System “Fight or flight” or “Type A’s”
There are 3 basic #SNS Dominant subtypes: Basic, Extreme, & Inefficient SNS Dominant types. The following is a summary of the average SNS Dominant types.
Personality traits vary widely in this group depending on whether they are more analytical vs. emotional. For instance, more emotionally based SNS Dominants are likely to be more volatile and “nervous” whereas the more analytical type does not. 
 


The sympathetic nervous system (SNS) activates the glands and organs that defend the body against attack, whether it is running from a saber toothed tiger or you are struggling with a dreadful job and difficult boss. It is called the fight or flight system and once activated, it directs more blood to the muscles, #adrenals and the brain yet away from the digestive organs and skin. The adrenals pump out #epinephrine while the sympathetic nerve endings throughout the body release #norepinephrine . This system is #catabolic , which simply means that energy is used to prepare for defense, rather than for nourishment, healing, or waste removal. #Sympathetic activity triggers the thyroid and adrenal glands to provide extra energy for fighting or running away. The heart rate and blood pressure also increase, just as the blood flow to the digestive system and kidneys decreases. This process is largely due to the intensified release of stimulating chemicals, known as #neurotransmitters #epinephrine and #norepinephrine . While this activity is critical for survival, those who have chronic activation of the SNS often develop #anxiety, #insomnia , heart racing or disease (heart failure), and adrenal #fatigue . They also have “goose bumps” more frequently than other types and tend to do best in warmer weather. 
 
A Sympathetic Dominant Nervous System often leads to significant gastro-intestinal issues due to the poor #digestion of meats and fats. These folks often feel as though food "sits like a rock in my gut". Due to the rising levels of Norepinephrine (the body’s flight or fight neurotransmitter), digestion shuts down to reserve precious resources for survival. Chronic activation can lead many to feel agitated, jittery, wired, & restless as well as prone to sleep disturbances and anxiety. They may also experience the vicious cycle of the “Wired but tired” sensation when eating an inappropriate diet or taking the wrong supplements, which in their case, is filled with sweets and other junk foods or heavy proteins. When a dysfunctional sympathetic nervous system reigns supreme, one may experience anxiety, stress, or feelings of panic, which should normally only occur in response to a perceived threat. Subsequently, they may overreact to even the mildest of daily troubles. 



These individuals often start out thin and active yet poor diets—usually filled with sweets and starchy carbs often lead to later weight gain. When busy or stressed, they frequently forget to eat regularly, if at all. They are often pale, do not tolerate cold weather and tend to have colder hands & feet. Such individuals are often impatient and easily frustrated or angered, yet it appears to quickly pass. They often make for volatile partners and bosses, in that they frequently explode; yet minutes later have already moved on. They are also frequently viewed as “intense,” “aloof,” or “bold,” and have a tendency of “sticking their foot in their mouths” by being too aggressive or forward. Nevertheless, #genetic & environmental factors influence this area considerably.


They are also very driven, ambitious, and motivated people who may excel in academics or in high energy vocations that require multi tasking and social interaction. Many also enjoy a stimulating debate or confrontation (attorneys, politicians, generals). When healthy ... ..more

#Neurotransmitter
Lab Tests indicating a need for #Glutamate #GABA balance:
Elevated glutamate, #glutamine #glutamic acid on urine AA test
Elevated #aspartate #aspartic acid on urine AA test
Low GABA (gamma aminobutyric acid) on a urine AA test
Low GABA on a Neurotransmitter test
Elevated #quinolinic on #OAT #Metabolic Test
#Seizures
#Stims
Poor eye contact
#Aggressive behavior

#Supplements to balance Glutamate and GABA:
Nerve Calm Formula RNA
Comfort RNA
Be Calm Glutamate Spray/Gaba Spray
Melatonin Sleep Spray
#Progesterone cream- Pro-Gest Body Cream
GABA
Pycnogenol
Grape Seed Extract
Valerian Root
Jujube
#Lithium Orotate based on UEE levels
L-Theanine
Taurine (not for ... ..more

Elevated #glutamate , glutamine, glutamic acid on urine AA test
Elevated aspartate, aspartic acid on urine AA test
Low #GABA (gamma aminobutyric acid) on a urine AA test
Low GABA on a Neurotransmitter test
Elevated quinolinic on OAT/Metabolic Test
#Seizures
#Stims
Poor eye contact
#Aggressive behavior

Supports to balance Glutamate and GABA:
Nerve Calm Formula RNA
Comfort RNA
Be Calm Glutamate Spray/Gaba Spray
Melatonin Sleep Spray
Progesterone cream- Pro-Gest Body Cream
GABA
#Pycnogenol
Grape Seed Extract
Valerian Root
Jujube
#Lithium Orotate based on UEE levels
L-Theanine
Taurine (not for CBS + or SUOX Mutation unless suggested on testing)

#supplements ..more

1) Biopterin/Neopterin: For those with A1298C mutations, #BH4 (also known as tetrahydrobiopterin) levels are typically quite low. This test provides insight to how low these levels are and why. If neopterin levels are high, then I am considering the possibility of a lingering infection, inflammation or chronic immune response that is preventing #biopterin from being formed. Thus, this test provides information not only potentially low biopterin levels but also why they may be low.

If a doctor simply prescribes BH4 without understanding the need to address the inflammation and chronic infections, it is band-aide treatment over a gaping wound ... ..more