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Annonymous

What is MTHFR A1298C Gene Mutation ?

  3 years, 12 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more

There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?

I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.

The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more

Annonymous

What does the COMT Gene Mutation mean?

  4 years, 3 months ago

What does it mean to "spare dopamine"? As mentioned in the above COMT discussion. Not use it? Not create it?  ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Annonymous

What is Sympathetic Dominance

  4 years, 3 months ago

#Sympathetic Nervous System “Fight or flight” or “Type A’s”
There are 3 basic #SNS Dominant subtypes: Basic, Extreme, & Inefficient SNS Dominant types. The following is a summary of the average SNS Dominant types.
Personality traits vary widely in this group depending on whether they are more analytical vs. emotional. For instance, more emotionally based SNS Dominants are likely to be more volatile and “nervous” whereas the more analytical type does not. 
 


The sympathetic nervous system (SNS) activates the glands and organs that defend the body against attack, whether it is running from a saber toothed tiger or you are struggling with a dreadful job and difficult boss. It is called the fight or flight system and once activated, it directs more blood to the muscles, #adrenals and the brain yet away from the digestive organs and skin. The adrenals pump out #epinephrine while the sympathetic nerve endings throughout the body release #norepinephrine . This system is #catabolic , which simply means that energy is used to prepare for defense, rather than for nourishment, healing, or waste removal. #Sympathetic activity triggers the thyroid and adrenal glands to provide extra energy for fighting or running away. The heart rate and blood pressure also increase, just as the blood flow to the digestive system and kidneys decreases. This process is largely due to the intensified release of stimulating chemicals, known as #neurotransmitters #epinephrine and #norepinephrine . While this activity is critical for survival, those who have chronic activation of the SNS often develop #anxiety, #insomnia , heart racing or disease (heart failure), and adrenal #fatigue . They also have “goose bumps” more frequently than other types and tend to do best in warmer weather. 
 
A Sympathetic Dominant Nervous System often leads to significant gastro-intestinal issues due to the poor #digestion of meats and fats. These folks often feel as though food "sits like a rock in my gut". Due to the rising levels of Norepinephrine (the body’s flight or fight neurotransmitter), digestion shuts down to reserve precious resources for survival. Chronic activation can lead many to feel agitated, jittery, wired, & restless as well as prone to sleep disturbances and anxiety. They may also experience the vicious cycle of the “Wired but tired” sensation when eating an inappropriate diet or taking the wrong supplements, which in their case, is filled with sweets and other junk foods or heavy proteins. When a dysfunctional sympathetic nervous system reigns supreme, one may experience anxiety, stress, or feelings of panic, which should normally only occur in response to a perceived threat. Subsequently, they may overreact to even the mildest of daily troubles. 



These individuals often start out thin and active yet poor diets—usually filled with sweets and starchy carbs often lead to later weight gain. When busy or stressed, they frequently forget to eat regularly, if at all. They are often pale, do not tolerate cold weather and tend to have colder hands & feet. Such individuals are often impatient and easily frustrated or angered, yet it appears to quickly pass. They often make for volatile partners and bosses, in that they frequently explode; yet minutes later have already moved on. They are also frequently viewed as “intense,” “aloof,” or “bold,” and have a tendency of “sticking their foot in their mouths” by being too aggressive or forward. Nevertheless, #genetic & environmental factors influence this area considerably.


They are also very driven, ambitious, and motivated people who may excel in academics or in high energy vocations that require multi tasking and social interaction. Many also enjoy a stimulating debate or confrontation (attorneys, politicians, generals). When healthy ... ..more

What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.

2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more

A chemical made in the BH4 cycle, which is used to produce dopamine and serotonin, neurotransmitters strategic in regulating mood, sleep, attention and focus, reward seeking behavior, addiction, and sense of wellbeing. BH4 is also critical in the urea cycle (waste facility) for cleaning up ammonia and making nitric oxide. A shortage of this important chemical has widespread repercussions.

Tetrahydrobiopterin BH4 Cycle produces the BH4 used for making neuro-talkers (dopamine, epinephrine, nor-epi, serotonin, & melatonin). It cleans up toxic ammonia in The Waste Cycle & makes Nitric oxide to protect the heart & brain.

Though controversy exists regarding this cycle’s function, Dr. Yasko’s theory indicates that The Big Motherflipper (MTHFR A1298C) may drive this cycle in the reverse direction and several independent studies support this finding. This leads to a chemical exchange among BH2 to BH4, a multi-purpose product that is used in both the Waste Facility (urea cycle) and BH4 Industry. Within the Better Health 4 Life Industry, BH4 produces chemicals known as neurotransmitters, or neurotalkers (NTs), including dopamine, serotonin, melatonin, norepinephrine, and epinephrine. NTs are central for the communication between nerves and cells as well as stabilizing the crisis response, mood, and sleep cycles. Chronically low BH4 levels increase the risk for ADD/ADHD, Bipolar Disorder, OCD, insomnia, depression, anxiety, and many other quality of life issues. Think of this company as AT&T with a philanthropic twist since it donates BH4 to the Waste Facility for environmental clean up as well as supporting the community in health & wellbeing.

The Waste Facility uses BH4 to clean up toxic ammonia and generates nitric oxide, an element that keeps blood vessels open and free of plaque. Yet if BH4 is scarce, it cannot clean up waste or deliver vital nutrients to the Power Plant (fumarate) so that noxious chemicals back up into SAM’s Corporation. Given the fact that it takes 2 grains of BH4 to clean up 1 granule of ammonia, as well as 2 of BH4 to create just 1 bit of nitric oxide, its easy to see how problems might arise. This underscores the BH4 Industry’s role throughout the community since unlike an actual factory; it isn’t permitted to shut down for repairs or maintenance.

While there are many factors that may impact this cycle, several are listed below:

1. A ... ..more

The following are the most important issues to address as soon as you can:
Dietary changes: Reducing neurological irritation and achieving Glutamate #GABA balance is critical!
1). Excitotoxins: The more excitotoxins you have coming into your body will only serve to undo many of the helpful measures you’ve already implemented as well as those below. Therefore, I highly recommend a gluten (wheat, rye, barley), casein (*dairy), & soy free diet. See the attached sheets/PDF regarding dietary guidance. In the end, you can only do the best that you can so if finances do not permit this, simply avoid these ... ..more

Annonymous

What does the COMT Gene Mutation mean?

  4 years, 3 months ago

To learn more about COMT Gene:
Dr. Richard Deth PhD
http://wn.com/oxidative_str...

Dr. Jill James PhD
1) http://www.ucdmc.ucdavis.ed... (2006 lectures, please scroll down for oxidative Stress Lecture as well).

2) http://www.ucdmc.ucdavis.ed... (2010 Lecture Methylation/Oxidative stress). http://www.youtube.com/watc...
 ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Wow. What a thread! My serum B6 was a bit over ref range. My OAT showed it to be low. So my doctor thinks I'm not processing or absorbing it. She started me on P5P, but I have to spread my 33 mg of it throughout the day, or else I get jitters and tingly extremities. I'm not sure my OAT was interpreted optimally. My mag RBC was 5.5 before I recently increased supplementation. I know I have some kind of source of lack with zinc, because starting that cured my chronic insomnia. I have brain inflammation ... ..more

1) Let's treat all this stuff now! By and large, #supplements are probably some of the safest treatments you will ever find, particularly when one considers the side effects associated with most prescription medicines. However, every single thing that you take has benefits and drawbacks. Simply stated, this means that supplements should be treated as medication. When you consider that many of the #methylation defects require any number of vitamins, enzymes, and co-factors to work more efficiently, these replacements have a crucial purpose. Since #methylation is instrumental in so many reactions, from proper #immune system function and making new ... ..more