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Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

Annonymous

What does the Livewello Gene App do?

  2 years, 11 months ago

The Raw Data you receive from 23andMe can be translated by Livewello for a 1-time fee of $19:95. LiveWello is unique because it gives users much more than just a 900 SNP Gene report: LiveWello will give you your report for 600,000 SNPs, AND attaches 11 resources for learning to each Gene.

Updates are FREE for Livewello users: Free updates are crucial as it allows users get their results for new SNPs when 23andMe adds new SNPS to your raw data during their Chip updates. It is also crucial for when new research is added to information about ... ..more

1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.

How does the Livewello App work with your Genetic Raw Data?
https://docs.google.com/a/l...

2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more

Published by Frank Marshall · March 26, 2015 at 2:12pm

The Compare Reports Tool allows you to view and compare up to 5 different people's Gene variance reports side-by-side. Comparing your Gene Reports provides side-by-side comparison with other profiles like the friends or family members in your LiveWello Account.

This tool is for those who have received their Gene results from 23andMe AncestryDNA or almost any other Gene Testing company.

Before you can do this, please make sure that:



--Everyone has generated the same Livewello Gene report you want to compare.


--Everyone has exchanged their "Add-Me" link with each ... ..more

You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More

6 Ways A DNA Test Can Help You Optimize Your Diet

Matching Genes and Vitamins. A Personalized Plan May Be in Your Future

Why would you need to run a Genetics test?
https://docs.google.com/doc...

LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!

b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas

DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more

Vimeo

A Standard Gene Report with information looks like this:  https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.

1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more

Vimeo

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

If it is not already in the Gene Library https://livewello.com/snps/... then:

1) Go to https://livewello.com/gwas Read about the GWAS tool If a condition is not listed there, solid research connecting genes to that health condition, have not been found or made.

2) Type in the health condition slowly and you'll start to see options pull up. Select the appropriate one. Results showing rsIDs and Genes will pull up. If you'd like a detailed report, we suggest you go through each PubMed citation and click the "Read Pubmed Citation" button. It will open ... ..more

Physicians don't always know what to do with your genetic information because epigenetics and pharmacogenomics are relatively new fields, and everyone is trying to catch up.  Also Traditional/Allopathic physicians have very limited time in which to  go over all the information that you hand over to them, so the best way to present them with new information like this, is to share a link to your Report and make sure you tell them to read the associated medical references that come with your App. For instance, every Gene in the LiveWello Gene App report is directly linked to ... ..more

Vimeo

Annonymous

What is pharmacogenomics?

  3 years, 10 months ago

Pharmacogenomics is the study of how genes affect a person’s response to drugs. This relatively new field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.

Many drugs that are currently available are “one size fits all,” but they don’t work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions ... ..more

A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a person’s genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent. These genetic changes contribute to the development of a disease but do not directly cause it. Some people with a predisposing genetic variation will never get the disease while others will, even within the same family.

Genetic variations can have large or small effects on the likelihood of developing a particular disease. For example, certain mutations in the BRCA1 or BRCA2 ... ..more

The University of Utah Genetic Science Learning Center provides information about genetic disorders that explains why some mutations cause disorders but others do not. #Livewello

The National Coalition for Health Professional Education in Genetics explains how mutations can be harmful, neutral, or beneficial.

#Livewello ..more

Annonymous

What is MTHFR A1298C Gene Mutation ?

  3 years, 10 months ago

By Helen Janneson Bense

A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.

Functions of BH4
Cofactor for all three isotypes of nitric ... ..more

Your #Livewello gene variance report is a graphical representation of your genetic raw data, displayed as a color coded chart. You can start learning by reviewing the phenotypes colored as red for homozygous, and yellow for heterozygous. Even though these SNPs appear as "abnormal phenotypes" on your report, this does not necessarily mean that you will manifest the associated disease. It is still a good starting point to learn more about these health conditions that may affect you.

Your report has 5 columns: SNP, rsID, Minor Allele, Genotype and Phenotype. Data in each of these columns has hyperlinks which take ... ..more

Annonymous

What is The Citric Acid Cycle ?

  4 years, 1 month ago

The Citric Acid Cycle AKA “The Power Company” is essential for processing and converting all dietary nutrients (vitamins, minerals, fats, amino acids) into useable forms of energy just as any power industry processes coal, gas, or oil for energy production. If you visualize this cycle as a clock, each hour represents an area in which one nutrient converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within this clock. This may lead to significant metabolic (chemical processing) imbalances within ... ..more

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#MTHFR #Lithium
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.

Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more

Annonymous

What is Glutamate ?

  4 years, 1 month ago

Glutamate is the major excitatory #neurotransmitter and the most commonly found NT in the brain. It is required for #learning and #memory , however, an excess of #glutamate is actually toxic to brain cells and nerves. #LouGehrig’s is the most well known disease of glutamate excess but newer evidence reveals many other disorders may be related such as #Autism , #CFS, many #seizure disorders, #Migraines , #MS , and many more. Glutamate balances #GABA ’s calming effect.
High levels can cause nerve and brain cell death and injury through inflammation. High or imbalanced glutamate levels are clearly involved in many neurological diseases such ... ..more

Julie Matthews: There is overwhelming scientific support for “diet and nutrition intervention” for ADHD and autism. Many studies indicate that children with autism and ADHD have deficiencies in nutrients such as zinc, iron, fatty acids, and that supplements improved symptoms. There are studies showing benefit with nutritional support for autism and ADHD. There are also studies on B6 and magnesium helping improve symptoms of autism. One study on children with autism showed that a multivitamin-mineral formula improved all areas of autistic symptoms studied including: language, play, sociability, hyperactivity, cognition, eye contact, and more. The aggregate science screams “pay attention to ... ..more