Introduction to The Vagus Nerve
In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.
The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.
The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more
By Helen Janneson Bense
A1298C single nucleotide polymorphism (SNP) affects the enzyme known as 5,10 MethyleneTetraHydroFolate Reductase (MTHFR). This polymorphism involves a down regulation of the MTHFR enzyme, responsible for the backwards reaction of the folate cycle, where 5-methylfolate (5MTHF) is converted into tetrahydrofolate (THF). This reaction is most important for the production of BH4 – tetrahydrobiopterin. Each turn of the folate cycle and conversion of 5MTHF to THF produces 1 molecule of BH4. In heterozygous and homozygous states, enzyme activity will be compromised by
approximately 30% and 70% respectively.
Functions of BH4
Cofactor for all three isotypes of nitric ... ..more
High dose #FolicAcid is the worst thing a person with the MTHFR gene mutation should take.
If a doctor tells a person with the #MTHFR gene mutations to take Folic ACID then that doctor does not really understand anything about the #L-Methyl Folate receptors on the Blood Brain Barrier [BBB]. The doctor does not realize that high dose Folic ACID is just going to block up the L-Methyl Folate Receptors on the BBB. When Folic ACID gets into the L-Methyl Folate Receptors it BLOCKS the receptor and it doesn't get into the brain and neither does the L-Methyl ... ..more
There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?
I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.
The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more
It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.
Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more
￼￼￼￼￼￼￼￼￼￼￼What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.
2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more
#CBS #NOS Gene Mutation
• Flapping or hand tremors
• Dark circles under eyes
• Disorientation, and brain fog
• Hyperactive reflexes
• NMDA receptor activation, leading to glutamate excitotoxicity
• Tremor of the hands
• Paranoia, panic attacks
• Memory loss
• Hyperventilation (often associated with decreased Carbon dioxide/CO2)
• Central nervous system toxicity
How to reduce Ammonia levels:
The following examples assist in balancing this toxic waste
• Yucca with meals/protein snacks
• Charcoal flush (only 1-2 x week) after last meal of the day (typically 9-10PM)
• CBS/NOS Caps
• MTHFR A1298C Caps (L-Biopterrin increases BH4 levels and the milk thistle also provides ammonia ... ..more
Acetylcholine is known as the inhibitory #Neurotransmitter System
The first #neurotransmitter to be discovered in 1921. Its’ importance lies in the fact that it stimulates muscles to contract. This NT alters heart muscle contractions and impacts muscle function throughout the body. It’s also strategic in vocalizations/ #speech and #swallowing . Acetylcholine is critical for #attention , #alertness , and #memory . People with #Alzheimer’s , #Parkinson’s , #ALS , and #Myasthenia Gravis have substantial #dysfunction within acetylcholine activity or breakdown.
Low levels are associated with #depression , and a lack of #concentration & #emotion as well as poor #muscle tone, #forgetfulness , and poor #sleep “light sleepers ... ..more
Lithium has been known for years to be useful for #bipolar disorder. Despite all that is known about lithium and its impact on biochemical pathways, no one has defined the mechanism by which lithium has its impact on bipolar disorder. It is likely to be an effect on multiple pathways. There are a number of enzymes in the body that are known to be impacted and inhibited by lithium.
Lithium comes together with methylation at #COMT, the enzyme catechol-o-methyl-transferase. COMT breaks down #dopamine and #norepinephrine. Dopamine is a critical #neurotransmitter for motivation, focus and attention, among other functions ... ..more
Glutamate is the major excitatory #neurotransmitter and the most commonly found NT in the brain. It is required for #learning and #memory , however, an excess of #glutamate is actually toxic to brain cells and nerves. #LouGehrig’s is the most well known disease of glutamate excess but newer evidence reveals many other disorders may be related such as #Autism , #CFS, many #seizure disorders, #Migraines , #MS , and many more. Glutamate balances #GABA ’s calming effect.
High levels can cause nerve and brain cell death and injury through inflammation. High or imbalanced glutamate levels are clearly involved in many neurological diseases such ... ..more
CBS C699T cystathionine beta synthase AKA The Hole in the Bucket. This Priority # 3 Mutation
Tip! It is crucial to address any gut issues before you thoroughly address the CBS defect. Since chronic gut issues lead to higher bacterial loads, thus leading to higher ammonia production as well as leaky gut (reducing nutrient absorption and increased risk for food sensitivity) this area is paramount. You can begin to address the CBS prior to fully addressing gut issues though they should be done in concert. Since the CBS is one of the most important issues to address, I’ve decided to ... ..more
1) Let's treat all this stuff now! By and large, #supplements are probably some of the safest treatments you will ever find, particularly when one considers the side effects associated with most prescription medicines. However, every single thing that you take has benefits and drawbacks. Simply stated, this means that supplements should be treated as medication. When you consider that many of the #methylation defects require any number of vitamins, enzymes, and co-factors to work more efficiently, these replacements have a crucial purpose. Since #methylation is instrumental in so many reactions, from proper #immune system function and making new ... ..more