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What is ACAT Gene Mutation

  4 years, 3 months ago

ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.

Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.

Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.

The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.

Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.

Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more


What is the Folate Cycle ?

  4 years, 3 months ago

The Folate Cycle Produces organic, homegrown RNA & DNA. Converts folate into usable forms to keep HCY* in check & sends on to SAM’s for more work tags. *HCY/Homocysteine

The Folate Cycle is the “Organic Farming Region” where everything is homegrown. This Region grows “organic” work tags (methyl groups) and is instrumental in the front-line production of new RNA and DNA. Still, this plantation is a bit old fashioned, employing a chain gang (homocysteine) to help them get the work done. Though rarely considered in everyday life, RNA & DNA are essential to making you unique, as well as directing health ... ..more

Urine & stool changes throughout #detoxification . Oftentimes, the urine will change in color and/or clarity as you layer in important cofactors and #methyl groups. The following rules typically apply and if in doubt, obtain a UTM/UEE or fecal metals. Bear in mind that #cadmium precedes lead whereas #nickel often precedes #mercury. You may also see high cadmium levels due to the presence of #HPylori. Moreover, high viral #titers tend to coincide with the presence of heavy metals. Dr. Yasko has found that in some cases, the mercury and other metals were not eliminated (even with chelation therapy) until the ... ..more

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These are the ultimate “bad guys” that roam from place to place stealing every cell’s positive energy and leaving them for dead. How are these criminals produced? Though there are many contributing factors, the Urea Cycle
( waste facility ) is by far, the largest free radical and oxidant producer in the community. Remember the waste facility aka #urea cycle is responsible for cleaning up most of the toxic waste generated within the community. Think of this cycle as your local garbage dump replete with trucks transporting recyclables and trash via the liver’s main highway ( #CBS ). In the Waste Facility ... ..more

From: http://www.stopthethyroidma...
"As explained well in the revised STTM book, which you should have on hand and bookmarked at the doctors office. The book is in English, Spanish, German and Swedish.

TSH: for diagnosis of hypopituitary, NOT to diagnose or dose your hypothyroidism (unless it’s high). If you allow a doctor to diagnose or dose you by this lab test and range i.e. to say you are normal simply because it’s in range or below 10…you’ll could still be hypothyroid.
Free #T4 and Free #T3 (note the word “free”–important since it measures ... ..more

It produces a defective MTHFR enzyme of different varieties i.e. it functions less than optimally, such as performing at only 40% of its capacity, or 70% of its capacity. It can mean you won’t break down toxins or heavy metals well i.e. you could find yourself with high iron, or high copper, or high mercury….etc. High copper can also cause low iron.
The defective enzyme doesn’t break down folate vitamins properly (of which folic acid is the precursor to), which can cause high homocysteine, which can increase your risk of coronary heart disease (arteriosclerotic vascular ... ..more


What is an Excitotoxin ?

  4 years, 3 months ago

#Excitotoxins excite the nerve or brain cell to death.

MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more



What are Sulfur & Thiols

  4 years, 3 months ago

Andy Cutler informs us that many mercury toxic people are intolerant to certain #foods , commonly known as ‘sulfur foods’, which have a high free thiol content. Consuming foods high in thiols raises the circulating thiol levels that in turn mobilizes #mercury and creates symptoms. He notes, “You typically get a couple of hours of feeling good, energized, happy, and then libidinous, then you feel tired, draggy and depressed, which goes on for a day to a week. Of course if you are eating sulfur foods at each meal these all get stacked up and you can never figure out what ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

This means you have one mutation for the 1298C gene. You get one gene from each parent. If you are homozygous (+/+) for 1298A it means you got it from both parents.

From Carol Savage M.D.
Having just one copy of MTHFR A1298C is perhaps the most controversial of all the SNPs.
I have found a few sources that report that the A1298C may interfere with the reverse direction of the MTHFR enzyme and therefore affects the folate cycle more so than the Methylation Cycle.

In any case it is always better to just have one copy of a mutation ... ..more

From Dr Ben:
In general, those with C677T mutations have decreased ability to produce methylfolate, increased cardiovascular risk, increased risk of blood clots, increased pain and inflammation and increased chemical sensitivity. Recommendations below support the reduction of these issues by increasing the body’s inherent ability to restore function through nutritional biochemistry.
Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.
Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.
Avoid folic acid blocking drugs such as birth control or Methotrexate.
Avoid drugs which increase ... ..more

Many enzymes are dependent upon Selenium as a helper.
Rec: Selenium #Supplement 200 mcg/day

Selenium gets depleted when mercury levels are high.
One selenium molecule can sequester [grab up] 5-10 molecules of mercury. If Selenium is all bound up with Mercury then it will not be available to assist enzymes for proper thyroid function.

Avoid eating the fatty parts of deep sea fish where the Mercury tends to locate. For example cut away the fatty strip of Sward Fish and do not eat that.

MOST of the conversion of #T4 into #T3 and reverse T3 [rT3] occurs in ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

For some, heavy metals, virus and other toxins and pathogens are a significant factor. As you move through the adding in the foundation and methylation supports, many supports will aid in the release of considerable amounts of mercury, aluminum, virus, and other harmful substances. Still, some have a much higher toxic burden than others and will require more aggressive measures.
Rather than utilizing aggressive methods, apply less intensive measures that will generally accomplish this goal.
Nevertheless, if you have rigorously worked through the protocol and find that you have not reached your goal, this is the time to consider:

Natural ... ..more


What is the impact of a CBS Mutation ?

  4 years, 3 months ago

SUOX Sulfite oxidase AKA Sulfites to Sulfate Priority # 4 Mutation
This is the enzyme that converts sulfites to a less toxic form as sulfate and is heavily impacted by mercury.
This is a very strategic defect that converts less toxic sulfites to sulfates through the CBS region, AKA, transsulfuration. However, having MTR/MTRR defects will affect this enzyme so that it can have what we call a “functional defect”. This means that it isn’t actually defective but because it isn’t getting what it needs, it becomes faulty and doesn’t process nearly as well. Anyone who reacts to ... ..more