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Annonymous

How can I stimulate my vagus nerve

  2 years, 10 months ago

SOURCE: http://selfhacked.com/2015/...


Introduction to The Vagus Nerve

In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.

The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.

The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more

*Circulatory & blood clotting factors
*DNA synthesis & repair via thymidine synthesis
*Gene expression via epigenetic regulations such as histone modification
*Nitric oxide synthesis, aka blood vessel elasticity
*Removal of homocysteine, a potentially toxic and atherogenic amino acid
*Synthesis of powerhouse antioxidants such as Glutathione & SOD
*Neurotransmitter synthesis & degradation - dopamine, serotonin, norepinephrine, glutamate, GABA
*Biotransformation (aka “metabolism & detoxification”) of chemicals, carcinogens & drugs
*Synthesis of immune cells
*B-12 & Folate utilization
*Organ, tissue and fetal development

While their program is expensive it does seem like it would really make one a kind of expert.

Now if I could just find common, insured tests for ... ..more

8 Factors that Affect Your Methylation Process

--Genetics – Like an estimated 20 percent of us, you could be genetically predisposed to high homocysteine

--Poor diet – The word “folate” comes from “foliage.” You need to eat plenty of leafy greens, beans, fruit, and whole grains to get adequate levels of vitamins B6 and B12, betaine, and folate. Egg yolks, meat, liver, and oily fish are the main dietary sources of vitamin B12 — so long-term vegan diets can be a problem. Plus, certain compounds can raise levels of homocysteine and deplete the B vitamins. These include excess animal protein, sugar, saturated fat ... ..more

I found this excellent description in Amy Yasko's forum: ch3nutrigenomics.com. It was posted by one of the members on the site- raji: http://www.ch3nutrigenomics...
This is a private blog, but it is a very rich source of information about methylation, nutrigenomics and dietary supplementation

Here is a copy of the post:

"Common Terminology:

Methyl group: A methyl group is simply a single carbon atom bonded to 3 hydrogen atoms (CH3).

Methylation: Transfer of methyl groups from one chemical to another is called methylation. Essentially any chemical compound that has a methyl group as part of its chemical ... ..more


Summary of analogies used in methylation community: CEOs: Directs each corporation in organized steps
Supervisors: Enzymes such as MTHFRs, COMT, SHMT, and BHMT
Enzymes are proteins that are produced by living cells and regulate the body’s process to breakdown products, such as ammonia.
Employees: Chemicals, proteins, DNA, etc.
Work tags: Methyl groups (Homocysteine, SAM, Methionine) The Chain Gang: Homocysteine (HCY)
Synopsis of the Cycles
1). Power Plant = Citric Acid Cycle =
Formerly known as the Kreb’s cycle) Recognized as the mitochondrial or energy cycle
2). Garbage Dump (& Recycling) =
The urea cycle, ammonia cleanup & nitric oxide production (heart/blood vessel protection)
3). Better Health 4 Life Corp (BH4) = Communications “AT&T” & toxic waste cleanup Neurotalkers: Dopamine, Serotonin, & Norepi

4). SAM’s Corp. = Methionine Cycle =
The major producer of methyl donors and the passageway to the garbage dump (NOS) & liver via the CBS enzyme
5). Farmer Folate = Folate Cycle =
Homegrown” RNA & DNA, methyl groups and Homocysteine (HCY) regulation

The Meaning of Methylation
Methylation is truly a multi-tasking marvel that allows us to be “healthy and human.” Though this highly intricate process occurs within each cell as well as in the fluid supplying the brain and within the liver, it is responsible for the most vital undertakings throughout body chemistry. Methylation determines who we are, what we look like, and how we behave and it is central to our physical, emotional, and mental wellbeing. Without methylation, we could not survive; hence, it is the perfect pathway to focus on for understanding autoimmune ... ..more

Annonymous

What is Epinephrine

  4 years, 5 months ago

#Epinephrine is one of the “Fight or Flight” #Hormones This NT is derived from #norepinephrine & released by the #adrenals. Hence, it is also known as #adrenaline . Epinephrine is also essential in #metabolism and regulates attention and mental focus & clarity as well as arousal (alertness & waking up), and thinking. It also inhibits #insulin release and raises the amount of fatty acids in the blood; both of which you’ll require for fuel. This very neurotransmitter induced anxiety and heart racing the moment you heard the word “ #Methyltetrahydrofolate ” or “ #methylation .” Epinephrine also raises your #bloodpressure and speeds up your heart rate.
High levels have been linked to sleep problems, #anxiety and #ADD or #ADHD. Low levels can result in #fatigue , lack of focus, and difficulty losing weight. ..more

Annonymous

What does Methylation do?

  4 years, 5 months ago

The Major Tasks of Methylation
In order to provide a brief overview, the following methylation tasks have been vastly streamlined. In reality, there is an endless array of both direct and indirect Methylation activities within the human body. Even so, this summary should provide greater understanding of this highly complex pathway, as well as the complications that can arise from various defects or toxic exposures.

Methylation is responsible for the following:
1. Nervous system function (brain, spinal cord, & nerve cells). It’s critical for the insulation around nerves (myelin), which allows signals to properly transmit via this sheath, or outer ... ..more

The Vitamin-D controversy…
by ADMIN on APRIL 7, 2013

As anyone who has read my regular posts online, you have learned that I am one of few wellness guys who isn’t ga-ga over Vitamin-D. It’s not the 1st time that I’ve cut against the grain in my career, but I want to offer an explanation that will hopefully explain my counter-cultural rationale…
http://gotmag.org/the-vitam...

In my humble opinion, Vit-D is the most misunderstood, but over-recommended supplement on the Planet. What is worth noting is that it is, in fact, a Hormone — not a Vitamin, and ... ..more

Kwame Iwegbue

What is CYP1A1?

@iwegbue   4 years, 5 months ago

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by ... ..more

MULTICHEMICAL SENSITIVITY…and #MTHFR
#Methyltetrahydrofolate [MTHFR]
The MTHFR Enzyme is in charge of making #L-Methyl Folate which is the final product of that enzymatic reaction.
L-Methyl folate [5-MTHF] is needed to convert #HOMOCYSTEINE into #Methionine.

HOMOCYSTEINE
With an insufficient amount of L-Methyl Folate there may be a buildup of HOMOCYSTEINE. Too much Homocysteine can cause all sorts of problems such as:
1. Increased blood clotting
2. Irritation and damage to the intima [inner lining of blood vessels]
3. Interfere with cartilage development and healing
As a result of the elevated HOMOCYSTEINE the person will be at greater risk of ... ..more

Annonymous

What is an Excitotoxin ?

  4 years, 5 months ago

#Excitotoxins excite the nerve or brain cell to death.

MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more

YouTube

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Annonymous

How does Methylation influence mood ?

  4 years, 5 months ago


It is important to understand the basics of methylation, and although a more detailed study of #methylation chemistry may be interesting, for our needs, it is not really necessary to study it here as it will only serve to confuse matters, so only the most important aspects will be considered.

Put simply, the methylation process makes #neurotransmitters (mood building blocks), and the issue of a person being an under or over methylator can be confusing, because there is contradiction between the various sources of information on the methylation process. For our purposes, we'll say that an over methylator is ... ..more

Annonymous

What are Free Radicals & Oxidants ?

  4 years, 5 months ago

We frequently hear terms such as free radicals, #oxidative stress, and #antioxidants yet what exactly do these mean? Normally, a healthy cell has paired electrons—one that is positive and another that is negative.

Free radicals are molecules without positive electrons and are created whenever there is oxidation, AKA oxidative stress. This is really just a normal part of the everyday fallout of metabolism and by itself, isn’t necessarily a bad thing. Nonetheless, a city overwrought by criminals easily overwhelms the honest and industrious residents. Soon enough, the best and brightest citizens flee to the suburbs while this once ... ..more

Annonymous

WHAT IS MTHFR?

  4 years, 6 months ago

MTHFR is a a key enzyme necessary for the metabolism of folate, an important B vitamin. In other words, MTHFR most often refers to a genetic mutation that affects our ability to methylate or convert folic acid from the food we eat, or supplements we take into Methylfolate (L-MTHF). L-MTHF is referred to as the "active" or usable form of folate that is required by our cells. Since our body's cells cannot utilize folic acid, it must go through a metabolic pathway or 4-step process to become converted into Methylfolate (L-MTHF) so our cells can use it. It is ... ..more

Annonymous

What is CYP1B1 R48G ?

  4 years, 5 months ago

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Data provided by NCBI ..more

Annonymous

What is Oxidation ?

  4 years, 5 months ago

This occurs when free oxygen radicals are created during the metabolism of normal oxygen cells. These free radicals are missing an electron and search out other molecules to combine with in order to become complete again. This is akin to having a single guy beat up another fellow so he can steal his girl. Unfortunately, in doing so, they create charges that damage other cells as well as the areas surrounding them. This process leads to oxidation or rust. In effect, your body is "rusting" as it goes through life and this is what leads to aging. It also explains ... ..more

Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting terms for a nutrient they really need.

Understanding which form of methylfolate is best must be clear.

Why all the confusion?

Because there are so many different terms used for methylfolate.

By the end, you will understand everything you need to know about methylfolate.

More significantly – you will understand how to pick the right form of methylfolate.

Terms often used for methylfolate are:

Methylfolate
L-MTHF
L-Methylfolate
L-Methylfolate Calcium
D-Methylfolate
D-5-Methylfolate
Levomefolic Acid
Metafolin
5-MTHF
5-Methylfolate
5-Methyltetrahydrofolate
L-5-MTHF
L-5-Methyltetrahydrofolate
6(S)-5-MTHF
6(S)-5-Methyltetrahydrofolate ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Besides the most obvious reason to take Oral Contraceptives/BCPs, you can also be prescribed them for medical reasons. It could be endometriosis, estrogen dominance or others. However taking BCPs when you have the MTHFR mutation may cause some problems. This would also be true if you already had pernicious anemia.

Taking the Pill effects Folate and B12 metabolism. Since having the MTHFR mutation already effects these two items taking BCPs just weakens the folate cycle further. I believe folks without the mutation can just up the amount of food they take with folate in it. But if you have ... ..more