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COMT and VDR Genes and DOPAMINE and NOREPINEPHERINE…and people sensitive to methyl donors.

Those with the Vitamin D Receptor Taq [VDR Taq (+/+)] mutations do not make Dopamine and therefore Norepinepherine very well.

Those with the Catechol-O-Methyl Transferase [COMT +/+] mutations cannot break down Dopamine and Norepinephrine very well.

A normal VDR [-/-] and the abnormal COMT [+/+] enzyme essentially aggravate the situation so that the concentration of Dopamine may be increased.

When the person has a perfect VDR taq [-/-] and they have the COMT [+/+] mutations then:

The good working VDR taq [-/-] allows them to make plenty of Dopamine.

The lousy COMT [+/+] causes ... ..more

Annonymous

Any idea what Methyl Donors are ?

  3 years, 8 months ago

Limit with COMT+/+ or VDR -/-
Unless you are consuming an excessive amount, there is really no need to limit natural foods with methyl or sulfur donors.
Foods: Eggs, Spinach, Kale, & Caffeine—Tea, Coffee, Chocolate
MSM
Melatonin CoQ-10/Idebenone
Carnitine
Theanine
SAMe
Methyl B-12
Curcumin
Quercetin
DMG
TMG
Folapro
Metafolin
Deplin (5-MTHF)
#MethylDonors #Methylation #Supplements ..more