The Methionine Cycle is the major work tag (methyl donor) manufacturer. SAMe has over 400 functions in the community. Also serves as the main route through to liver & Waste cycle.
Methionine (SAM) Cycle AKA “SAM’s Corporation,” As SAMe has over 400 known methylation reactions, SAM’s Corporation is the chief work tag producer. It’s also where most of the action occurs since it contains the major thoroughfare to the liver (CBS & transsulfuration). While this often works to its’ advantage, it can also pose a safety risk since failure along this route may result in calamity (see Waste Facility ... ..more
The recommendations to work on CBS is b6 active form p5p and molybdenum to balance copper and zinc and help break down excess sulfates. You can get some sulfate strips these ones http://www.amazon.com/gp/aw.... You want to get your urine sulfates down to at least 800 preferably 400 before adding in methylfolate and methylb12. ..more
#Excitotoxins excite the nerve or brain cell to death.
MSG/Glutamates Please do not attempt to eliminate every last version of #MSG from your diet or you’ll be absolutely insane by the end of the month, it is much too difficult. Just be mindful that there are a lot of hidden ingredients everywhere If a restaurant says they have no MSG in their food, they are almost always referring to the fact that they don’t add MSG to their food but it comes in vats that way already. Also, there are loopholes so that food manufacturers may label ... ..more
MAO-A (Monoamine oxidase A) is a critical enzyme involved in breaking down important neurotransmitters such as serotonin, norepinephrine, and dopamine. While a homozygous (+/+) mutation is very common, prolonged periods of stress, violence, or trauma can lead to epigenetic changes that further decrease enzyme activity. On the table above, males only have one allele since the gene is inherited through from their mother since it is located on the X chromosome.
Males are more likely to have this mutation, represented on the table as homozygous (+). Only females can be heterozygous (+/-) for this mutation.
When a (+/+) MAO-A mutation is combined with a ... ..more
CBS (cystathionine beta synthase) catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine. Dr. Yasko considers addressing CBS mutations as first priority aside from addressing the gut.
This enzyme converts homocysteine to cystathionine. In a separate reaction, cystathionine is then converted to cysteine which in turn goes to taurine or glutathione among other things.
CBS defects are actually upregulations. This means the enzyme works too fast. Therefore, it is common to see low levels of cystathionine and homocysteine since there is a rapid conversion to taurine. This leads to high levels of taurine and ammonia.
The upregulation ... ..more
You wanna work on cbs first because it's an upregulation when you start adding methylfolate and methylb12 and you don't have cbs under control all of the folate and b12 will used up down the cbs pathway instead of being recycled in the methylation pathway. It's a kind of a big balancing act. But once you start finding the right balance and getting better you will start to see the positives. The big ones I use for cbs is b6 active form p5p and molybdenum to balance copper and zinc and help break down excess sulfates. You ... ..more
The following are the most important issues to address as soon as you can:
Dietary changes: Reducing neurological irritation and achieving Glutamate #GABA balance is critical!
1). Excitotoxins: The more excitotoxins you have coming into your body will only serve to undo many of the helpful measures you’ve already implemented as well as those below. Therefore, I highly recommend a gluten (wheat, rye, barley), casein (*dairy), & soy free diet. See the attached sheets/PDF regarding dietary guidance. In the end, you can only do the best that you can so if finances do not permit this, simply avoid these ... ..more
CBS C699T cystathionine beta synthase AKA The Hole in the Bucket. This Priority # 3 Mutation
Tip! It is crucial to address any gut issues before you thoroughly address the CBS defect. Since chronic gut issues lead to higher bacterial loads, thus leading to higher ammonia production as well as leaky gut (reducing nutrient absorption and increased risk for food sensitivity) this area is paramount. You can begin to address the CBS prior to fully addressing gut issues though they should be done in concert. Since the CBS is one of the most important issues to address, I’ve decided to ... ..more
SUOX Sulfite oxidase AKA Sulfites to Sulfate Priority # 4 Mutation
This is the enzyme that converts sulfites to a less toxic form as sulfate and is heavily impacted by mercury.
This is a very strategic defect that converts less toxic sulfites to sulfates through the CBS region, AKA, transsulfuration. However, having MTR/MTRR defects will affect this enzyme so that it can have what we call a “functional defect”. This means that it isn’t actually defective but because it isn’t getting what it needs, it becomes faulty and doesn’t process nearly as well. Anyone who reacts to ... ..more