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Why is my B12 supplement not working?

2 years, 7 months ago

Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICxr5AKDA Genetics & Health Question: Why is my B12 supplement not working? Answer: Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to binding problems in the person whether genetic or acquired. Taking It In An Inactive Form – they take an inactive b12, either cyanob12 or hydroxyb12. The research “validating” their use was primarily for reducing blood cell size in Pernicious Anemia, keeping the serum b12 level over 300pg/ml at the end of the period between injections. They make a statistically significant effect that can be seen in lab tests in a significant percentage of people compared to placebo. They do not heal most damage done by active b12 deficiencies and have little or no effect on the vast majority of symptoms. They may even block active b12 from receptor sites hindering the effects of real b12. They both cause a keyhole effect of having only a very limited amount (estimated at 10mcg/day) that can actually be bound and converted to active forms. They in no way increase the level of unbound active cobalamins which appear required for most healing. Enzyme Problems – Some people are totally incapable of converting these to active forms because they lack the enzyme (see below) Improper Usage – They take a sublingual tablet of active b12 and chew it or slurp it down quickly reducing absorbtionback to that same 1% and limited to binding capacity. With sublingual tablets absorbtion is proportionate to time in contact with tissues. I performed a series of absorbtion tests comparing sublingual absorbtion to injection via hypersensitive response and urine colorimetry. The sublingual b12s must be retained under the upper lip or tongue for 45 minutes to two hours for effectiveness with verified absorbtion ranging from 15% to 25% with urine colorimetry and by effect. Wrong Brand – Of the many brands of sublingual methylb12 only some are very effective. Some are completely ineffective and some have a little effect. Of 10 brands of methylb12 systematically tested, 2 rated 5 stars with 5 hypersensitive testers. They were Enzymatic Therapy 1mg, and Jarrow Formulas 1 mg and 5mg. In addition Country Life Dibencozide rapy 1mg, and Jarrow Formulas 1 mg and 5mg. In addition Country Life Dibencozide (adenosylb12) also rated 5 stars. One brand of 5mg methylb12 rated ZERO stars, completely ineffective in all testers. The other 7 brands rated 1-3 stars. Solgar Metafolin (methylfolate) is one of two brands available and is superior to folic acid in every way. Decayed Product – or injectable methylb12, if it is exposed to too much light (very little light actually is too much) it breaks down. Broken down methylb12 is hydroxyb12. It doesn’t work at healing brain/cord problems of those who have a presumed low CSF cobalamin level. That requires a flood of unbound methylb12 and adenosylb12 (2 separate deficiencies) that can enter by diffusion. Adenosyl12from sublinguals can ride along with injected methylb12. They don’t take BOTH active b12s. Low Dosage – they don’t take enough active b12s for the purpose, espcially amounts needed to penetrate CSF by diffusion. Lack of methylfolate. Lack of other critical cofactors. Lack of basic cofactors. Taking glutathione or glutathione generating cofactors that induce an active b12 deficien Four Distinct Types of Vitamin B12 Deficiencies – Most people consider b12 deficiency to be a unitary thing. it isn’t. There are 4 distinct and different b12 deficiencies each with it’s own set of characteristics, and a person can have any combination of the 4. In addition is the definition of “deficiency” itself. Each type of active b12 has it’s own deficiency symptoms. The results of shutting down the neuronal mitochondria are different from loosing myelin or slowing down impulses or lacking a wide variety of neural transmitters or who knows what other effects. Unless a CSF draw is done, there is no way to detect these deficiencies. There are no standards of what is “deficient” even if a draw is done. Pragmatically these deficiencies can both be detected and differentiated. For a variety of reasons I won’t go into now, I could make a case for ME being a CSF deficiency of largely methylb12 specifically for instance. Potential Challenges To B12 Absorption Can’t absorb b12 for a wide variety of reasons including IF insufficiency (Pernicious Anemia) of either genetic or autoimmune causality. Can’t bind B12s for transport Genetic Challanges Decreased CSF cobalamin levels – hypothetical cause, confirmed problem Lacking Enzyme to convert methylb12 to adenosylb12 – confimed, named cobalamin letter disease Lacking Enzyme to convert adenosylb12 to methylb12 – confimed, named cobalamin letter disease Lacking Enzyme to convert cyanocobalamin to methylb12 or adenosylb12 – confimed, named cobalamin letter disease Lacking Enzyme to convert hydroxycobalamin to methylb12 or adenosylb12 – confimed, named cobalamin letter disease Lacking Enzyme to convert glutathionylcobalamin to methylb12 or adenosylb12 – hypothetical cause, some evidence for problem Lacking enough enzyme(s) to convert folic acid to sufficient methylfolate, – confirmed cause Each of those can be overcome. On top of the genetic reasons, the methylb12 generated by bacteria is not all the same and some bacteria breeds may generate superior methylb12. This is totally unexplored but may account for some brand differences. Personal Story –I personally appear to lack all of those enzymes for interconversion of forms of b12 and folic acid for instance and had all four b12 deficiencies. When I find something that works 5% of the time I find out why it doesn’t work 100% of the time. That’s engineering. Because my body is hypersensitive to these changes it’s very much like debugging software and I can know sometimes in hours or less what takes others weeks or months to find out. The information I am presenting here is a distillation of decades of experience and 6 years of active experimentation on myself and children. And I always do much reading to find why I should try some things or why they worked/didn’t work afterwards. By Fred: http://phoenixrising.me/folder/treating-chronic-fatigue-syndrome-mecfs-vitamin-b12-when-it-doesnt-work-by-fred #B12 #MTHFR #ChronicFatigue http://resqua.com/100005927200207/why-is-my-b12-supplement-not-working

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How can I stimulate my vagus nerve

2 years, 5 months ago

SOURCE: http://selfhacked.com/2015/...

Introduction to The Vagus Nerve

In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.

The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.

The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDKlZAKDA Genetics & Health Question: How can I stimulate my vagus nerve Answer: SOURCE: http://selfhacked.com/2015/07/30/28-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it/ Introduction to The Vagus Nerve In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate. The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology. The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve in the parasympathetic system, but it’s by far the most important one in that it has the most far reaching effects. The word vagus means “wanderer,” because it wanders all over the body to various important organs. The vagus nerve connects to the brain, gut (intestines, stomach), heart, liver, pancreas, gallbladder, kidney, ureter, spleen, lungs, fertility organs (females), neck (including pharynx, larynx, esophagus), ears and tongue. In the brain, it helps control anxiety and depression. In the gut, it helps control stomach acidity, digestive juices and gut flow. Since the vagus nerve is very important for increasing gut flow/motility, having less vagus activation will increase your IBS-C risk, which is a result of a slower flow (R). Stimulating the vagus nerve increases the release of histamine in stomach cells, which helps with the release in stomach acid (R). So low stomach acidity is usually, in part, a vagus nerve problem. By releasing intrinsic factor, the vagus nerve is important help you absorb B12 (R). In the heart, it controls heart rate variability, heart rate and blood pressure. Vagus activation will lower the risk for heart disease and other major killers (R). In the liver and pancreas, it helps controls glucose balance (R). In the gallbladder, it helps release bile, which can help you get rid of toxins and break down fat. In the kidney, the vagus nerve promotes general kidney function. It helps with glucose control and increases blood flow (R), which helps filtrate your blood better. Vagus activation also releases dopamine in the kidneys, which helps excrete sodium (R) – and thereby lower blood pressure. The vagus nerve goes to the bladder. (R) A side effect of vagus nerve stimulation is urinary retention (R), which may mean that less vagus stimulation can cause you to urinate frequently. Indeed, I see frequent urination among many of my clients (also due to low vasopressin, aldosterone and high cortisol). In the spleen, it can reduce inflammation (R). But vagus activation will reduce inflammation in all target organs (by releasing acetylcholine) (R). It helps control fertility and orgasms in women by connecting to the cervix, uterus and vagina. Women can actually experience orgasms simply from the vagus nerve (R). In the tongue it controls taste and saliva and in the eyes it controls the tear producing glands (R). A friend asked me what connection between having to go to the bathroom and congestion. It’s the vagus nerve because it controls mucous production and also your colon flow. Satiety and relaxation following a meal is in part caused by an activation of vagus nerve transmission to the brain in response to food intake (R). The vagus nerve explains why a person may cough when tickled on the ear, such as when trying to remove ear wax with a cotton swab (R). Vagus nerve stimulation helps people with tinnitus because of its connection to the ear. It matters in conditions like GERD not only because it controls stomach acidity, but also because it it controls the esophagus. The vagus nerve is largely responsible for the mind-body connection, since the vagus nerve goes to all your major organs (except your adrenals and thyroid). It’s intimately tied to how we connect with one another — it links directly to nerves that tune our ears to human speech, coordinate eye contact and regulate emotional expressions. It influences the release of oxytocin, a hormone that is important in social bonding (R). Studies have found that higher vagal tone is associated with greater closeness to others and more altruistic behavior (R). Vagal activity has also been notably elevated during mother-infant interactions. Infants had lower vagus activity with mothers who were depressed/angry/anxious during pregnancy (R). These studies emphasize the impact in being a good, positive and happy person. So many studies show that optimistic and happy people are much healthier. Your health and the health of your kids will pay a big price if you’re an anal curmudgeon. Also, don’t surround yourself with moody and high strung people. “Type A” personalities (of which I’m one) need to learn how to chill the fuck out. There’s no where to go and nothing to accomplish, when it comes down it. Your happiness is the only goal and we are the only ones putting extra stress on ourselves, creating inner and interpersonal conflicts when they aren’t needed. If you’re too focused on money and “accomplishing” and less on being a good and loving person, you will pay for it. The Vagus Nerve and Hormones Vagus Nerve Stimulation normalizes an elevated HPA axis (CRH, ACTH and Cortisol) (R). The vagus nerve is important for releasing testosterone. If it’s not working well, it could be a reason for low testosterone (R). Testosterone can make people more aggressive, but this is not the case when the vagus nerve is functioning right (R). Estradiol can reduce pain in some circumstances and this is mediated by the vagus nerve (R). Insulin activates the vagus nerve in some ways through a domino of steps and leads to decreased glucose production by the liver (activates K-ATP channels in the arcuate nucleus, decreases AgRP release, and through the vagus nerve decreases enzymes that increase blood glucose -G6P, PEPCK) (R). In rats, the thyroid hormones (T3) increase appetite through activating the vagus nerve, which also increases ghrelin (R). Ghrelin increases growth hormone and hunger by stimulating the vagus nerve signal from the brain to the gut, and this is abolished by capsaicin (in chili) (R). Proper functioning of the vagus nerve is important for production of GHRH (growth hormone releasing-hormone), and IGF-1 (R). The vagus nerve can stimulate other hormones such as your Parathyroid hormone (R), which is important for conversion of vitamin D3 to active D (1,25). Stimulating the vagus nerve causes it to release vasoactive intestinal peptide (VIP) (R), which is often low in people with mold conditions. NPY, an anti-anxiety and hunger increasing hormone, prevents the decrease in heart rate from vagal stimulation (R), so it’s antagonistic to its effects. The Vagus Nerve and the Circadian Rhythm Signals from the circadian control center (SCN) are often transmitted by the vagus nerve. For example, mucin production by your gut and lungs has a rhythm that’s controlled from your SCN (R). The point is if your circadian rhythm is broken, your vagus nerve will be broken to some degree. Conditions Which Vagal Nerve Activation Can Help Because the vagus nerve is associated with many different functions and brain regions, research shows positive effects of vagal stimulation for a variety of conditions, including but not limited to (R): Various Anxiety Disorders, Heart disease, Leaky gut, OCD, Alzheimer’s, Memory and Mood disorders, Migraines, Fibromyalgia, Obesity, Tinnitus, Alcohol addiction, Autism, Bulimia, Severe mental diseases, Multiple sclerosis Chronic heart failure Acetylcholine Acetylcholine is the principle vagal neurotransmitter. This means that it will have many of the same effects as vagal stimulation because this is how the vagus nerve stimulates various organs. Acetylcholine significantly lessens the release of cytokines such as TNF, IL-1beta, IL-6 and IL-18 in LPS-stimulated human immune cultures (R). Alpha GPC is the best way to increase acetylcholine. However, I don’t know if it will get to where it needs to go and in the proper dosage, so I doubt it’s as good as vagus stimulation. Some Basics on How the Vagus Nerve Works (Technical) Take a deep breath (or skip)…. You can stimulate or inhibit the vagus nerve in two ways. First, the vagus nerve impulse (activation) can flow from the brain to the rest of the body or from the body to the brain. When it flows from the brain it’s called a “vagal efferent.” When it flows from a place like the gut or some other part of the body, it’s called a “vagal afferent.” I don’t use these terms for simplicity. When the signal goes to the brain, it goes to a place called the nucleus tractus solitarius (NTS). Information from various places converges at the NTS and are assimilated. So in computer terms, the NTS is the processor when it comes to the vagus nerve. Information comes in form of neurotransmitters, peptides and hormonal signals to shape the resulting output response (R). From the NTS, there are nerve fibers that connect to another area called the dorsal motor nucleus of the vagus (DMV). Hormones or neurotransmitters can activate the vagus nerve from the DMV. For example, GABA in the DMV slows gut flow, but interestingly, other neurotransmitters don’t have an effect by themselves (they need other inputs) (R). From the DMV, the electrical or nerve signal gets transmitted to a place like the gut, via the vagus nerve (R). This happens via vagal “pre-ganglionic” parasympathetic neurons. These pre-ganglionic neurons connect to other “post-ganglionic” neurons and these use acetylcholine to stimulate organs that they connect to, like the gut. These neurons can also inhibit gut function by releasing nitric oxide (NO) or vasoactive intestinal polypeptide (VIP) (R). When you stimulate pre-ganglionic neurons in the DMV (animals), it excites the neurons that connect to the gut and increases gut flow (R). So your vagus nerve system can be messed up in 3 main ways: Communication to the brain (from an organ…via glutamate), communication within the brain (such as from the NTS or to the DMV) or communication from the brain to other areas in the body like the heart, liver, gut, etc…(R). Given the importance of the vagus nerve in the gut (and other organs), when it’s not working right, it will cause digestive disorders including dyspepsia, gastroparesis, esophageal reflux, colitis, anorexia and bulimia nervosa, to name a few (R). The higher the high-frequency heart rate variability is associated with more vagus nerve/parasympathetic activity (R, R2). The higher the low-frequency HRV, the more sympathetic and parasympathetic activation (both of them) (R, R2). 1) ICES/PEMF Magnetic fields are capable of stimulating the vagus nerve (R). Studies have found that PEMF can increase heart rate variability and increase vagus stimulation (R). I use a pulsed magnetic stimulator called ICES/PEMF on my gut and brain, which increases my appetite and stimulates me. This accords with the idea that it’s stimulating my vagus nerve. I recommend using this on your gut, brain, side of your neck, etc…. I notice my gut flow increases and inflammation is reduced everywhere when I put this on my gut. At first I didn’t understand how it can have systemic effects if I placed it on my gut, but the vagus nerve is probably why, given that the vagus nerve is stimulated by magnets. Buy: ICES® DigiCeutical® A9a Model System. Use the code SHCOIL to get a free coil or equivalent money off. International shipping is available. The batteries run out really quickly and many rechargeable batteries do not fit in. I use these rechargeable batteries. They fit and work well. I use these two Bandages for ICES: Bandage (3 Inch) or Bandage 6 Inch. I also use this tape to reach spots that aren’t suitable for the bandages, including my shoulder, where I got an injury. It doesn’t really hurt when you rip the tape off. Read more about ICES. 2) Meditation There are two types of meditation that can stimulate the vagus nerve. Loving-kindness meditation increases vagal tone, as measured by heart rate variability (R) (found via a link from low histamine chef). Jon Kabat-Zinn has a Guided Mindfulness Meditation that includes loving-kindness meditation. Also “Om” chanting stimulates the vagus nerve (R, R2). 3) Have Positive Social Relationships You can do this as a meditation or you can actually find someone truly special who is worth your love and kindness. The latter is better, but not easy to get. I truly believe that to live an optimally happy life you need to be a good and giving person, especially to the people you love and those close to you. In a study, participants were instructed to sit and think compassionately about others by silently repeating phrases like “May you feel safe, may you feel happy, may you feel healthy, may you live with ease,” and keep returning to these thoughts when their minds wandered (R). Compared to the controls, the meditators showed an overall increase in positive emotions, like joy, interest, amusement, serenity and hope after completing the class. And these emotional and psychological changes were correlated with a greater sense of connectedness to others — as well as to an improvement in vagal function as seen in heart-rate variability (R). Simply meditating, however, didn’t always result in a more toned vagus nerve. The change only occurred in meditators who became happier and felt more socially connected; for those who meditated just as much but didn’t report feeling any closer to others, there was no change in the tone of the vagal nerve (R). I also get immense pleasure when I’m kind to a someone I like. I want my loved ones to be safe, comfortable, at ease, happy and live a good life….. And it gives me tremendous joy if I can help someone I care about get to that state. I guess because I feel happier, I can be considered selfish. So be it. If you’re interested, you can read my rant on relationships. 4) Breath Deeply and Slowly Your heart and neck contain neurons that have receptors called “baroreceptors.” These specialized neurons detect your blood pressure and transmit the neuronal signal to your brain (NTS), which goes on to activate your vagus nerve that connects to your heart to lower blood pressure and heart rate. The result is a lower fight or flight activation (sympathetic) and more rest and digest (parasympathetic). The baroreceptors can be more or less sensitive. The more sensitive they are, the more likely they are going to fire and tell your brain that the blood pressure is too high and it’s time to activate the vagus nerve to lower it. Slow breathing, with a roughly equal amount of time breathing in and out increases the sensitivity of baroreceptors and vagal activation, which lowers blood pressure and reduces anxiety by reducing your sympathetic nervous system and increasing your parasympathetic system (R). Breathing around 5-6 breaths per minute in the average adult can be very helpful (R). Tip: You need to breath from your belly and slowly. That means when you breath in, your belly should expand or go out. When you breath out it your belly should cave in. The more your belly expands and the more it caves in, the deeper you’re breathing. 5) The Breathing Exerciser, and Exercises Breathing in and out with resistance will likely stimulate your vagus nerve better-kind of like jogging with a backback. I use this Breathing Exerciser, which I am happy with. I bought a different one that I didn’t like. You can use the Emwave2 to increase Heart Rate Variability, which will increase your vagal tone. This device will give you feedback and it will allow you to pace your breathing better. Another breathing exercise it to breathe out as hard as you can until it’s really uncomfortable and until you notice how awake you are. I haven’t seen studies on this, but I suspect it will help with your vagus nerve by transiently increasing your sympathetic system, which will react with a parasympathetic response. Diaphragmatic breathing: http://www.clevelandclinicwellness.com/programs/NewSFN/pages/default.aspx?Lesson=1&Topic=5&UserId=00000000-0000-0000-0000-000000000705 6) Probiotics The gut nervous system connects to the brain through the vagus. There is increasing evidence pointing to an effect of the gut microbiota on the brain. Animals given L. rhamnosus caused various positive changes in GABA receptors that were mediated by the vagus nerve (R). ((((GABA(B1b) receptors increased in cortical regions (cingulate and prelimbic) and decreased in the hippocampus, amygdala, and locus coeruleus. It reduced GABA(Aα2) expression in the prefrontal cortex and amygdala, but increased GABA(Aα2) in the hippocampus.)))) These are my recommended products. All of them work: Probiotic (Garden of Life) Probiotics (Swanson) Probiotic (VSL-3) Probiotics (prescript assist) 7) Exercise Mild exercise stimulates gut flow. This is mediated by the vagus nerve, which means that exercise stimulates the vagus nerve (R). 8) Cold I have unreleased interviews with Todd Becker and Ben Greenfield (will release them), who have been measuring their HRV and found cold showers to improve their HRV the most. Studies show that when your body adjusts to cold, your fight or flight (sympathetic) system declines and your rest and digest (parasympathetic) system increases – and this is mediated by the vagus nerve (R). Any kind of acute cold exposure will increase vagus nerve activation (R). You can dip your face in cold water to start (R). I graduated and now take fully cold showers, expose myself to cold, and drink cold water. I use an Ice Cube Tray and Ice Cube Maker to make ice cubes to put in my smoothie. I wear a Ice Helmet/Cryohelmet – (I use the adult regular size). A cheaper Cold Hat is also good, but the cryohelmet is better. I use both. I actually have 2 Cryohelmets. I also use a Cold Vest. If you’re obese, you need to expose your whole body to cold. If you’re thin and have cognitive issues, it’s most important that your head be exposed to cold. 9) Massages Massaging certain areas like your carotid sinus, which is located on your neck can stimulate the vagus nerve. This helps reduce seizures (R). Pressure massages are used to help infants gain weight by stimulating gut function and this is largely mediated by activating vagus nerve (R, R2). Foot massages can also increase vagal activity, heart rate variability and lower your heart rate and blood pressure (R). All of these decrease heart disease risk. My preferred approach is to have a loved one or friend massage you or pay for a massage if you’ve got a lot of money (they’re extremely pricey). I love getting and giving massages, especially to a partner. 10) Fasting Intermittent fasting or reducing calories increases the high frequency heart rate variability (animals) (R), which is a marker of vagal tone. Indeed, many anecdotal reports show that intermittent fasting benefits heart rate variability. When you fast, part of the decrease in metabolism is mediated by the vagus nerve. Specifically, the vagus detects a decline in blood glucose and a decrease of mechanical and chemical stimuli from the gut. This increases the vagus impulses to the brain (NTS) from the liver vagus nerve, which slows the metabolic rate and raises our body temperature (i.e. we feel hotter) (R). Hormones such as NPY increase and CCK and CRH decrease when this happens (R). When we eat, the opposite happens. Satiety-related stimulatory signals from the gut contribute to increased sympathetic activity and stress-responsiveness (higher CRH, CCK and lower NPY) (R). Fasting can increase activity in the subdiaphragmatic vagus, which can increase the sensitivity to pain (not good) (animals) (R). In female rats, fasting increases the number of estrogen receptors in certain parts of the brain (NTS and PVN) and this requires the vagus nerve (R). So the vagus nerve can make you more sensitive to estrogen. 11) Sleep or Lay on Your Right Side Studies have found that laying on your right side increases heart rate variability/vagal activation more than being on other sides. Laying on your back leads to the lowest vagus activation (R). 12) Yoga Yoga increases vagus nerve activity and your parasympathetic system in general (R, R2). A 12-week yoga intervention was associated with greater improvements in mood and anxiety than a control group who just did walking exercises. The study found increased thalamic GABA levels, which were associated with improved mood and decreased anxiety (R). Watch and perform this Yoga video, which I find very helpful to do at night. 13) Tai Chi Tai chi increases heart rate variability, and very likely vagus activation (R). 14) Tongue Depressors Tongue Depressors stimulate the gag reflex…. Gag reflexes are like doing push-ups for the vagus while gargling and singing loudly are like doing sprints. You need to perform them for several weeks to produce change. 15) Gargling Before you swallow water, gargle it first. The vagus nerve activates the muscles in the back of the throat that allow you to gargle. Gargling contracts these muscles, which activates the vagus nerve and stimulates the gastrointestinal tract. 16) Singing Loudly I do Om meditations in my Infrared Sauna. I also sing loudly. Sing at the top of your lungs while at home or in your car. This works the muscles in the back of the throat to activate the vagus. Just make sure I’m not around you when you do sing 😉 17) Acupuncture Traditional acupuncture points may offer vagus nerve stimulation (R). In particular, acupuncture to the ear stimulates the vagus nerve (R). Acupuncture is powerful enough that it stimulated someone’s vagus nerve enough that they died from too low of a heart rate (R). 18) Oxytocin Brain and oral intake of oxytocin increases vagal nerve activity from the brain to the gut (R), which induces relaxation and decreases appetite. Mice who had their vagus taken out didn’t have the appetite reducing effects of oxytocin (R). I use an Oxytocin spray once in a blue moon, but an Oxytocin sublingual should also work. 19) Serotonin Serotonin is capable of activating the vagus nerve through various receptors. The effects are mediated in part by activation of 5HT1A (R), 5-HT2 (R), 5-HT3 (R), 5-HT4 (R) and perhaps 5-HT6 (R) receptors. On the other hand, 5-HT7 receptors reduce vagus activation (R, R2). So serotonin will have some mixed effects, but overall it should stimulate the vagus nerve. You can take 5-htp to increase serotonin. 20) Chew Gum: CCK CCK directly activates vagal impulses to the brain (R). CCK’s ability to reduce food intake and appetite is dependent on the vagus nerve impulse to and from the brain (R). Chewing Gum should help increase CCK release. 21) Resistant Starch/GLP-1 GLP-1 is a satiating hormone that stimulates vagus impulses to the brain, which acts to slow the emptying of your stomach and make you feel fuller (R). (It also works by increasing CRH (R)). Hi-maize Resistant Starch is the best way to increase GLP-1. Use 40g a day to start. 22) Laughter As the saying goes, laughter is the best medicine. Many studies show health benefits from laughing (R). Laughter is good for cognitive function (R) and protects against heart disease (R). Laughter increases beta endorphins, nitric oxide and benefits the vascular system (R, R2). A study looked at 20 healthy older adults in their 60s and 70s, measuring their stress levels and short-term memory. One group was asked to sit silently, not talking, reading, or using their cellphones, while the other group watched funny videos. After 20 minutes, the participants took a short memory test. Participants who viewed the funny videos had much higher improvement in recall abilities, 43.6 percent, compared with 20.3 percent in the non-humor group. The humor group showed lower levels of cortisol (R). It seems like laughter is capable of stimulating the vagus nerve. A study done on yoga laughter found increased HRV in the laughter group. (R) There are various case reports of people fainting from laughter and this may be from the vagus nerve/parasympathetic system being stimulated too much. For example, fainting can come after laughter, urination, coughing, swallowing or shitting -all of which are helped along by vagus activation (R). There are case reports of people passing out from laughter who have a rare syndrome (Angelman’s) that’s associated with increased vagus stimulation (R, R2). Laughter is also sometimes a side effect of vagus nerve stimulation (R). 23) Coffee Enemas Enemas are like sprints for your vagus nerve. Expanding the bowel increases vagus nerve activation and caffeine increases bowel flow. First you need to purchase an Enema Bag, which includes the corresponding tubing. If you can spend a little more cash, go with the more pure, Stainless Steel Enema Buckets, especially if you have multiple chemical sensitivities. These are also easier to clean. I recommend watching some youtube videos so that you feel comfortable with the procedure before attempting it yourself. Make your organic coffee on the stove (best), or in your coffee pot with non-chlorinated filters to save time. For an example of how much coffee to use, if you use a drip coffee pot, use 2 tablespoons of coffee, and 4 cups of purified water. Then fill the enema bucket with the 4 cups of coffee (make sure the clamp on the silicon tubing attached to your enema bucket is closed before you do this, or you will spill coffee everywhere). Fill the rest of the bucket with 6 cups of purified water (or just leave an inch of space at the top of the enema bucket). The coffee mixture should be at room temperature/slightly warm. You will then need to lie on your right side. It is best to do this in the bathtub in case you spill anything. Place the bucket no more than 18 inches above your head, otherwise the coffee will flow too fast and you will not be able to retain it. Lubricate the anal tip of the tube with coconut oil, then insert the tube into your anus. Allow the coffee to slowly make its way in. If necessary, hold the clamp down on the silicone tube periodically to allow your body to adjust and absorb the coffee slowly. Once the coffee has drained from the bucket into your intestines, try to hold the contents in your bowel for 5 to 15 minutes. Over time you should be able to hold it the full 15 minutes. You will have urges to have a bowel movement, but hold the contents as long as you can. Some people do two coffee enemas back-to-back for the best effect. Be sure to replace your electrolytes and minerals shortly after. 24) Coughing or Tensing the Stomach Muscles When you bear down to eject your shit, you stimulate your vagus nerve. That’s why you might feel relaxed after taking a crap. So if you use your craping muscles, it will stimulate your vagus nerve (R). Just don’t shit your pants please. And don’t shart either. 25) Fish Oil – EPA and DHA EPA and DHA are capable of increasing heart rate variability and lowering heart rate (R). Fish oil/DHA (AMZN) or Fish Oil/DHA (IHERB)-LEF…IFOS certified… Fish Oil (AMZN) or Fish Oil (IHERB)-Nordic Naturals – High DHA…Triglyceride form.. 26) Make Sure Your Thyroid Hormones/T3 Are Normal In rats, the thyroid hormones (T3) increase appetite through activating the vagus nerve, which also increases ghrelin. (R) Put LLLT on your thyroid if it’s low. 27) MSH Alpha-MSH injection in the DMV moderately excites the vagus nerve to a degree in some conditions (R). Alpha-MSH is capable of preventing damage from a stroke via activating the vagus nerve, which suppresses inflammation (R, R2). I’ve tried MSH on myself. It has positive effects on the gut and libido as well, and is commonly low in people with mold sensitivities. 28) Ghrelin Ghrelin increases growth hormone and hunger by stimulating the vagus nerve signal from the brain to the gut, and this is abolished by capsaicin (in chili) (R). Ghrelin stimulates the pancreas from the brain via the vagus (R). I’ve taken GHRP2, which is a ghrelin acts on ghrelin receptors and has a similar effect. 29) Insulin Insulin activates the vagus nerve in some ways through intermediaries (activates KATP channels in the arcuate nucleus, decreases AgRP release, and through the vagus nerve, leads to decreased glucose production by the liver by decreasing enzymes that increase blood glucose (G6P, PEPCK)) (R). Having some carbs here and there might not be the worst idea. 30) Orexin Orexin neurons are found in NTS, DMV, and the area postrema – centers which control vagus nerve activation from the brain (R). Orexin stimulates the vagus nerve from the brain, which promotes gut flow (R). Orexin A can stimulate the pancreas from the brain (R). Orexin is capable of increasing glucose tolerance or insulin sensitivity via the liver vagus nerve (R). On the other hand, Orexin is capable of inhibiting the activation of the vagus nerve signals to the brain by competing with CCK (A) (R). #MTHFR http://resqua.com/100005927200207/how-can-i-stimulate-my-vagus-nerve

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Why is my B12 supplement not working?

2 years, 7 months ago

Learn more about Genetics & Health 13 views 3 more answers 2 Upvote

What to do after you receive your Gene Report?

2 years, 10 months ago

1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.

How does the Livewello App work with your Genetic Raw Data?
https://docs.google.com/a/l...

2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDMj4oKDA Livewello FAQs Question: What to do after you receive your Gene Report? Answer: 1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file. How does the Livewello App work with your Genetic Raw Data? https://docs.google.com/a/livewello.com/document/d/1FkQ5bZFPvwP_U2h3ufFiUTH3m6NwYgSwxWlS9ExhBuU/edit# 2) Get a Healthcare Practitioner who is qualified and understands Epigenetics. Share your Report with your Healthcare Practitioner Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is your own knowledgeable Healthcare Practitioner. Everyone differs in their symptoms, diagnosis and Gene mutations. Your own personal Healthcare practitioner will be the best recourse to helping you put a treatment or lifestyle plan in place once you have your Gene results. This is because, they will have the benefit of crucial information like a personal consult, examination and your functional lab results to efficiently address your health issues. Tips on How to Find a Qualified and Experienced Doctor: https://docs.google.com/document/d/16BrSnsxLEQ9dmAhPUoX030sJCaK2YNyzwnnRDwFF3Kg/edit?usp=sharing Health Practitioner Directory: https://livewello.com/practitioners a) Share all your Variance Reports with your Doctor. b) Read and Share the Notes in this Sample Report with your Doctor. It has some very good information which you should print and share with your Doctor too: https://livewello.com/snps/share?for=martin.dawson.606 (Contains only about 300 SNPs but Livewello's Gene App comes with 600,000 SNPs so it is a value for the money). You also get 12 resources for learning attached to each Gene and free updates so that when 23andMe adds SNPs to your raw data Livewello generates reports for them for free. c) Read about Personalized Medicine and the need to have have your Healthcare Practitioner customize a treatment plan to your needs based on your Gene Report, labs and a physical examination: http://www.vox.com/cards/genetictesting/what-is-personalized-medicine 3) Get even MORE Health Reports: Go to the Gene Library to search and install as many Health Reports as you'd like. Select any and click on "view report" to see your results: https://livewello.com/snps/library 4) Get your health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas Generate these reports and share them with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a LIvewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit! DIRECTIONS; a) Go to: https://livewello.com/gwas and enter the name of your health condition. If research has been done on it, the SNPs/Genes and research studies associated with that health condition will pull up. b) Once it does, click "copy to sandbox" and c) Click build SNP Template to view your own report. 5) Focus on certain Genes or SNPs by customizing Gene Reports: https://livewello.com/snps/sandbox Learn more about Sandbox: https://docs.google.com/a/livewello.com/document/d/1IrRpSqjVjPylUZ8bJvndF9u69YpiukfZvSXVUEvrT6E/mobilebasic 6) Network: Compare gene reports side-by-side with trusted family or friends to create a community around your journey to recovery. You can compare up to 5 people at a time. Start here: https://livewello.com/snps/compare Learn how to do this here: https://www.facebook.com/notes/livewello/how-to-share-your-gene-report-with-others-and-compare-your-results-side-by-side/946094618735093 Make sure everyone sharing has done this: a) https://www.facebook.com/notes/livewello/how-to-share-your-gene-report-with-others-and-compare-your-results-side-by-side/946094618735093 b) How to Share a Livewello Profile: http://resqua.com/100005927200207/how-do-i-share-a-profile 7) Empower yourself: Click on and use the 12 resources to information linked directly to each Gene and item in your Report to learn more. Each link composes their information to suit different learning styles. How to get more health information from your Gene Report: http://resqua.com/100005927200207/how-can-i-get-more-info-from-my-gene-report 8) Share all your Variance Reports with your Doctor and share the resources below with them too: Resources to read and share with your Doctor: a) Methylation Overview for Professionals http://www.drkendalstewart.com/wp-content/uploads/2011/09/Methylation-Overview-for-Professionals-10.11.pdf b) Information for Health Professionals http://www.kdheks.gov/newborn_screening/download/ACT/HCY_Info_for_Health_Professionals.pdf http://www.cdph.ca.gov/programs/nbs/Documents/NBS-DisordersDetectable011312.pdf c) Methylation Defects in Autism Disorders By Cindy Schneider M.D. http://www.center4autism.org/therapyMETH.asp d) Neil Rawlins 4-Part Video on MTHFR: http://www.youtube.com/watch?v=ZA8GUIRqIkE&sns=em e) MTHFR Related Health Problems by Stephen Smith M.D. http://www.mindmeister.com/12694596/mthfr-related-health-problems f) Heartfixer Online Dr. James Roberts: http://heartfixer.com/AMRI-Nutrigenomics.htm g) Autism Must Be Treated with Genetic Testing of Methylation:https://vimeo.com/81065604 h) Why does this Gene Report matter to your Patient ?http://www.sciencedaily.com/releases/2014/11/141114181115.htm?utm_source=feedburner i) What is Personalized Medicine? http://en.wikipedia.org/wiki/Personalized_medicine j) Genetic Testing: http://livewello.wordpress.com/2014/09/23/our-growth-so-far users k) About Livewello: https://www.facebook.com/notes/livewello/about-livewellos-gene-app/863565933654629 l) The Impact of Toxicity on us today: https://docs.google.com/a/livewello.com/document/d/1LF_3t-AjRdDGQMlbQJcQk2RCiNDyI6uZVOGahq29f2s/edit m) Tips on Finding a Qualified and Experienced Doctor:https://docs.google.com/a/livewello.com/document/d/1c_OhYd7iaUp53ZZbxqqhK4S10ZMYHWKyPhVrgc_oeJw/edit n) Steps to take when sharing your Report with your Doctor: https://www.facebook.com/notes/livewello/how-do-i-share-my-gene-report-with-my-doctor/888849811126241 9) Keep Track of your other Functional Lab results in order to monitor your progress or regress: https://livewello.com/data-apps 10) CONSIDERING SOME LIFESTYLE CHANGES? Use the free Lifestyle Data App with your doctor to: https://livewello.com/data-apps/review_app?name=lifestyle-data-app All of the above are free with your 1-time purchase of the Gene App at https://livewello.com/snps ( $19:95 ) The journey to recovery can be long and the field of genetics is gathering new information and research almost daily. With free updates, you need a tool that can partner with your for the long haul while respecting your need for personalized and integrative health care. All the best... ~ https://livewello.com/genetics Don't Forget to LIKE & FOLLOW us on Facebook: https://facebook.com/livewello QUESTIONS??? CONTACT US AT https://livewello.com/support DIRECTIONS to translate your Genetic Raw Data: 1) Download your Raw Data and save to your Desktop 23andMe users: https://www.23andme.com/you/download/ Ancestry users: Download & unzip the Autosomal Raw Data to get the text file 2) Upload it to your LiveWello Gene App at https://livewello.com/snps [The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.] Email https://livewello.com/support with questions Follow the links below and install as many Health Reports as you'd like by clicking "view report": These reports are all stored in the Gene Library where you can install as many as you'd like. MTHFR Gene SNPs: https://livewello.com/snps/library?action=preview&index=393575&for=demo TYPE 2 DIABETES GENES: https://livewello.com/snps/library?action=preview&index=806504&for=demo AUTISM SPECTRUM DISORDER, ADHD, BIPOLAR DISORDER, MAJOR DEPRESSIVE DISORDER, AND SCHIZOPHRENIA: https://livewello.com/snps/library?action=preview&index=379628&for=johnadams CELIAC DISEASE: https://livewello.com/snps/library?action=preview&index=417820&for=demo HYPOTHYROIDISM GENES: https://livewello.com/snps/library?action=preview&index=335986&for=demo ULCERATIVE COLITIS: https://livewello.com/snps/library?action=preview&index=186332&for=martin.dawson.606 THYROID RELATED GENES: https://livewello.com/snps/library?action=preview&index=427779&for=florence EHLERS-DANLOS GENES: https://livewello.com/snps/library?search=EDS POTS Genes: https://livewello.com/snps/library?search=pots POLYCYSTIC OVARIAN SYNDROME: https://livewello.com/snps/library?action=preview&index=482838&for=demo PORPHYRIA GENES: https://livewello.com/library/porphyria?author=demo METHYLATION: https://livewello.com/snps/share?for=martin.dawson.606 Histamine and Mast Cell related Gene Reports: HNMT Gene: https://livewello.com/snps/library?action=preview&index=420933&for=demo DAO Gene: https://livewello.com/snps/library?action=preview&index=431474&for=demo KIT Gene and Mast Cell Activation Disorder: https://livewello.com/snps/library?action=preview&index=811549&for=demo AOC1 & ABP1 Genes: https://livewello.com/snps/library?action=preview&index=600494&for=demo #Livewello http://resqua.com/100005927200207/what-to-do-after-you-receive-your-gene-report

Learn more about Livewello FAQs 8 views 0 Upvote

What is SNP Sandbox?

2 years, 10 months ago

The Sandbox tool is for creating an unlimited number of customized Health Reports with your raw data from 23andMe AncestryDNA or most other personal genomics testing companies. You can use it to create a customized report based on any Gene or SNP name you want added to it. It works best once you upload your raw data file.

This tool allows you to add thousands of SNPs of YOUR choice to your Report. You can use it to add SNPs to your Report that are not in your Standard Variance Report. So, if you've received your 23andMe, Ancestry, FTDNA ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICO8pAJDA Livewello FAQs Question: What is SNP Sandbox? Answer: The Sandbox tool is for creating an unlimited number of customized Health Reports with your raw data from 23andMe AncestryDNA or most other personal genomics testing companies. You can use it to create a customized report based on any Gene or SNP name you want added to it. It works best once you upload your raw data file. This tool allows you to add thousands of SNPs of YOUR choice to your Report. You can use it to add SNPs to your Report that are not in your Standard Variance Report. So, if you've received your 23andMe, Ancestry, FTDNA etc Raw Data results, and are looking for your results on a particular SNP or Gene, you can use The SNP Sandbox tool to check for it. SNP Sandbox is suitable for people who may have already run their Report with a different App and are looking to add even more SNPs/ Genes to their Variant Report. Once you’re done, you can add the Template to the Gene Library. There is NO EXTRA CHARGE for the SNP Sandbox Tool or the Gene Library. Once you pay for the Livewello Gene App, the SNP Sandbox and Gene Library features are free with your purchase. 1) Go to https://livewello.com/snps/sandbox or just click the ‘SNP Sandbox button’ on the left of your screen 2) Click on "rsIDs by Gene Name" and enter the Gene name. 3) Then click on "Search 23andMe" or ‘Show Suggestions’ button if your raw data is from another testing company. a) If you clicked the ‘Search 23andMe’ button you’d be prompted to sign in to 23andMe. b) Then you’d need to select and copy the entire page of results that 23andMe produces. c) Paste what you copied into the ‘SNP ids’ box 4) If your raw data is from another testing company, click on the ‘Show Suggestions’ button and click the ‘copy to sandbox’ button if results on your search are pulled up. 5) Click "Build SNP Template". Wait a few seconds for SNP Sandbox to fetch the data. 6) If the search was successful, the Gene Report will be populated. All SNP Sandbox templates are stored in the Gene library where it can be 7) Click “View Report” to see your results EXAMPLES of Templates built with the SNP Sandbox Tool: MTHFR: https://livewello.com/snps/library?action=preview&index=393575&for=demo YASKO's NUTRIGENOMICS GENES: https://livewello.com/snps/library?action=preview&index=356849&for=demo METHYLATION Genes: https://livewello.com/snps/library?action=preview&index=899200&for=demo DID YOU KNOW: The Livewello Gene App's SNP Sandbox Feature also allows you to: ~Compare 5 Variance Reports in your account side by side https://vimeo.com/86789213 and ~Copy a SNP Sandbox template to other profiles in your account. Frequently Asked Questions about the Livewello 23andMe Gene App: https://livewello.com/support #Livewello Questions? Email: support@livewello.com http://resqua.com/100005927200207/what-is-snp-sandbox

Learn more about Livewello FAQs 5 views 0 Upvote

How does the Livewello App work with your Genetic Raw Data?

2 years, 10 months ago

You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More

6 Ways A DNA Test Can Help You Optimize Your Diet

Matching Genes and Vitamins. A Personalized Plan May Be in Your Future

Why would you need to run a Genetics test?
https://docs.google.com/doc...

LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!

b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas

DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more

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ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDKgYEKDA Genetics & Health Question: How does the Livewello App work with your Genetic Raw Data? Answer: You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More 6 Ways A DNA Test Can Help You Optimize Your Diet Matching Genes and Vitamins. A Personalized Plan May Be in Your Future Why would you need to run a Genetics test? https://docs.google.com/document/d/1by5ivgZu3yKuOVFSZo3_C9IKwvvFYnZmrTnisgICsus/edit?usp=sharing LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it. So, how does the Livewello App work ? 1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop. 2) Go to the home page at: https://livewello.com/genetics On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents. 3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools: a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/library It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit! b) The GWAS Health Conditions Tool If you don’t see Gene Reports about your health issues in the Gene Library, use this tool: It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas DIRECTIONS FOR THE GWAS Health Conditions FEATURE To use the GWAS Health Conditions Tool go to <a>https://livewello.com/gwas</a> i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search. ii. Click on "copy to SNP sandbox" and iii. Click "build template" and "view report" to generate a report for yourself. c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972 EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/library?action=preview&index=786267&for=kems.86 MTHFR Gene SNPs: https://livewello.com/snps/library?action=preview&index=393575&for=demo d) Network with others like you in 2 ways! i) Users can join the Anonymous Gene community by clicking on any gene in your report then click on "connect anonymously": https://livewello.com/community ii) Compare Gene reports Users can Compare gene reports side-by-side with trusted family or friends. You can compare up to 5 different people's Gene Reports in 1 view. Start here: https://livewello.com/snps/compare Directions on How to Compare Gene reports side by side: https://www.facebook.com/notes/livewello/how-to-compare-gene-reports-side-by-side/1055190757842088 http://resqua.com/100005927200207/how-can-i-compare-reports-using-the-livewello-app Here are some of those thousands of reports. Follow the links below and install as many as you'd like by clicking "view report": HYPOTHYROIDISM GENES: https://livewello.com/snps/library?action=preview&index=335986&for=demo ULCERATIVE COLITIS: https://livewello.com/snps/library?action=preview&index=186332&for=martin.dawson.606 THYROID RELATED GENES: https://livewello.com/snps/library?action=preview&index=427779&for=florence Ehlers-Danlos Genes: https://livewello.com/snps/library?search=EDS POTS Genes: https://livewello.com/snps/library?search=pots POLYCYSTIC OVARIAN SYNDROME: https://livewello.com/snps/library?action=preview&index=482838&for=demo PORPHYRIA GENES: https://livewello.com/library/porphyria?author=demo TYPE 2 DIABETES GENES: https://livewello.com/snps/library?action=preview&index=806504&for=demo AUTISM SPECTRUM DISORDER, ADHD, BIPOLAR DISORDER, MAJOR DEPRESSIVE DISORDER, AND SCHIZOPHRENIA: https://livewello.com/snps/library?action=preview&index=379628&for=johnadams CELIAC DISEASE: https://livewello.com/snps/library?action=preview&index=417820&for=demo How-To Video: http://vimeo.com/96957497 e) Remember to take your Reports to your Dr or find a qualified healthcare practitioner: Health Practitioner Directory: https://livewello.com/practitioners Tips on How to Find a Qualified and Experienced Doctor: https://docs.google.com/document/d/16BrSnsxLEQ9dmAhPUoX030sJCaK2YNyzwnnRDwFF3Kg/edit?usp=sharing f) Lifestyle Changes to consider and discuss with your Doctor: https://livewello.com/data-apps/review_app?name=lifestyle-data-app Frequently Asked Questions about the Gene App: https://livewello.com/support What to do after you receive your Gene Report: https://www.facebook.com/notes/livewello/things-you-can-do-with-your-raw-data-once-they-arrive-from-23andme-ancestry-and-/881296868548202 Learning Resources to share with your Healthcare Practitioner: https://www.facebook.com/notes/livewello/things-you-can-do-with-your-raw-data-once-they-arrive-from-23andme-ancestry-and-/881296868548202 The Impact of Toxicity on us today... https://docs.google.com/a/livewello.com/document/d/1LF_3t-AjRdDGQMlbQJcQk2RCiNDyI6uZVOGahq29f2s/edit QUESTIONS??? GO TO https://livewello.com/support #Livewello http://resqua.com/100005927200207/how-does-the-livewello-app-work-with-your-genetic-raw-data

Learn more about Genetics & Health 4 views 0 Upvote

How can I get more info from my Gene Report?

3 years, 5 months ago

A Standard Gene Report with information looks like this: https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.

1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more

Vimeo

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDK0JcJDA Livewello FAQs Question: How can I get more info from my Gene Report? Answer: A Standard Gene Report with information looks like this: https://livewello.com/snps/share?for=martin.dawson.606 This sample contains some useful info worth sharing with your Doctor. 1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is available there. Information from each link is composed to suit different styles of learning and understanding. Just copy and paste any useful info you find there, into the 'notes' or 'description' portion of your Gene Report. The important thing to remember is that, whenever you see something that interests you, always copy and paste that information and its browser link into your description. Clicking on the "Edit Title and Description” button in a Gene Template, allows you to add any information you gather. 2) Search for Genes associated with a Health Issue that affects you: Your free Livewello Health Conditions Tool will help you find and generate your own results for Genes that Research Studies have associated with certain Health Conditions: https://livewello.com/gwas EXAMPLES of Templates built with this tool: HYPOTHYROIDISM GENES: https://livewello.com/snps/library?action=preview&index=335986&for=demo ULCERATIVE COLITIS GENES: https://livewello.com/snps/library?action=preview&index=186332&for=martin.dawson.606 How-ToVideo: http://vimeo.com/96957497 AUTISM SPECTRUM DISORDER, ADHD, BIPOLAR DISORDER, MAJOR DEPRESSIVE DISORDER, AND SCHIZOPHRENIA: https://livewello.com/snps/library?action=preview&index=379628&for=johnadams http://resqua.com/100005927200207/how-do-i-search-for-genes-associated-with-a-health-condition 3) Tips on sharing your Gene Report with your Doctor: http://resqua.com/100005927200207/how-do-i-share-my-gene-report-with-my-doctor 4) SNP Sandbox: This tool allows you to custom create Gene reports based on a Gene Name or any combination of SNPs: https://livewello.com/snps/sandbox You can then share your template to the Gene Library if you’d like and click “view report” to see your results for the SNPs in that Template. EXAMPLES of Templates built with SNP Sandbox: YASKO's NUTRIGENOMICS GENES: https://livewello.com/snps/library?action=preview&index=356849&for=demo MTHFR: https://livewello.com/snps/library?action=preview&index=393575&for=demo SNP Sandbox Tool Video for 23andMe users: http://vimeo.com/103512972 SNP Sandbox Tool Video for other Personal Genomics Company users: https://drive.google.com/file/d/0B3wi07iiWY7dd1lWdk1XQlN4SVU/edit?usp=sharing 5.Visit The Gene Library. It contains hundreds of Gene compilations that were created using the SNP Sandbox Tool and the Health Conditions Tool. By Clicking on a template link, users can use any of the entries to auto-generate a report for themselves or any profiles in their account: https://livewello.com/snps/library They can then click “view report” to see their results for the SNPs in that Template. An older Gene Library Video: https://vimeo.com/87970578 Examples of Some Gene Library Entries: PARKINSON’S DISEASE: https://livewello.com/snps/library?action=preview&index=41870&for=demoo LACTOSE INTOLERANCE: https://livewello.com/snps/library?action=preview&index=257796&for=florence o AUTISM SPECTRUM DISORDER, ADHD, BIPOLAR DISORDER, MAJOR DEPRESSIVE DISORDER, AND SCHIZOPHRENIA: https://livewello.com/snps/library?action=preview&index=379628&for=johnadams o CELIAC DISEASE: https://livewello.com/snps/library?action=preview&index=417820&for=demo Other tips on what to do with your Raw Data: What to do after you receive your Gene Results: https://www.facebook.com/notes/livewello/what-to-do-after-you-receive-your-gene-report/1055175377843626 What does the Livewello Gene App do? https://www.facebook.com/notes/livewello/what-does-the-livewello-gene-app-do/1069033519791145 Tips on How to Find a Qualified and Experienced Doctor: https://docs.google.com/document/d/16BrSnsxLEQ9dmAhPUoX030sJCaK2YNyzwnnRDwFF3Kg/edit?usp=sharing How does an App help with your Genetic Raw Data Results? https://docs.google.com/a/livewello.com/document/d/1FkQ5bZFPvwP_U2h3ufFiUTH3m6NwYgSwxWlS9ExhBuU/edit# Search and install as many Health Reports as you like: https://livewello.com/snps/library?author=ag9zfmxpdmV3ZWxsby1hcHByEwsSCldlYkFjY291bnQYkMTZAQw How to compare your friends and family member’s Gene Reports side-by-side: https://www.facebook.com/notes/livewello/how-to-compare-gene-reports-side-by-side/1055190757842088 10 valuable resources for those who have done their 23andMe and AncestryDNA test: https://www.facebook.com/Livewello/photos/a.1041255989235565.1073741827.1041255855902245/1093070924054071/?type=1&theater Questions? Visit: Frequently Asked Questions: http://resqua.com/tag/Livewello Tech Support Page: https://livewello.com/support #Livewello http://resqua.com/100005927200207/how-can-i-get-more-info-from-my-gene-report

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Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?

2 years, 11 months ago

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

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Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?

2 years, 11 months ago

Learn more about MTHFR 2 views 0 Upvote

What does it mean when the MTHFR C677T and A1298C Genes don't work properly

2 years, 11 months ago

MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
………………….

MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]

The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.

L-Methyl Folate is most beneficial to ... ..more

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I am sensitive to Methyl Donors. What should I do?

2 years, 11 months ago

SENSITIVITY TO METHYL DONORS By Carol Savage

Those who are very sensitive to methyl donors have to supplement with low dosages of different kinds of B12 and folate. Rotating them is likely the best approach.

They need to give their body TIME of accept the supplements, TIME to allow the biochemistry to adjust before adding in more...sometimes even skipping days when no supplements are taken.

A gentle approach is the best way to proceed if you are sensitive to methyl donors.
Link: https://www.facebook.com/gr...
#Methyl Donors #MTHFR ..more

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How can I learn some basic information about MTHFR and L-METHYL FOLATE

2 years, 11 months ago

MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDXs4QKDA MTHFR Question: How can I learn some basic information about MTHFR and L-METHYL FOLATE Answer: MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D. If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following: FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc. DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order to function. Other vegetables that include a good deal of natural DHF include: various kinds of beans, asparagus and brocholi.SUPPLEMENTING WITH... L-Methyl FolateL-methyl folate is not what we naturally eat. It is DiHydroFolate [DHF] that is primarily found in Greens and Beans. There now are several generic supplements with various amounts of L-Methyl Folate in them. At one time the amount of 5-MTHFR in non-prescription 5-MTHF was one mg or less. That fact has since changed, and supplements that are not prescription strength are in fact available now with 5mg or 10 mg in them. SUPPLEMENTATION WITH...Vitamin B12 People with Methionine Synthase Reductase [MTRR] snp mutations cannot transfer the methyl group form L-Methyl Folate onto "Naked" B12 [Cobalamin (I)] and these are the individuals who ususally need to supplement with Methyl-B12. But, those with COMT snps are usually sensitive to methyl donors and they do best if they take Adenyl-B12 or Hydroxy-B12 rather than Methyl-B12. VITAMIN B2 [Riboflavin] One of the Flavoproteins that Vitamin B2 is involved in making is FAD…Flavin Adenine Dinucleotide… [FAD/FADH2] is a rate limiting Cofactor for the enzyme MTHFR which makes L-Methyl Folate [5-MTHF]. FLAVOPROTEIN…definition A Flavoprotein is any of a class of conjugated proteins that contain flavins and are involved in oxidation reactions in cells. FLAVIN…definition Any of a group of yellow nitrogen-containing pigments, as riboflavin, that function as coenzymes. COENZYME…definition A coenzyme is a substance that enhances the action of an enzyme. [a coenzyme is a helper] ENZYME…definition An enzyme is a protein that functions as a catalyst to mediate and speedup a chemical reaction. AVOID extra FOLIC ACID if you have the MTHFR mutation[s] There is already plenty of Folic ACID in our processed foods. Folic ACID is a synthetic form of folate that can be converted into Dihydrofolate [DHF], but too much Folic ACID can get stuck in the Folate Receptor alpha [FRa] receptor sites on the Blood Brain Barrier [BBB]. Too much Folic ACID relative to the available L-Methyl Folate [5-MTHF] can prevent the real thing …L-Methyl Folate [5-MTHF]….from getting into the brain. ONLY L-methyl Folate can actually get into the brain through the BBB by way of the Folate Receptor alpha [FRa] receptors. This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways. The BLOOD BRAIN BARRIER [BBB]…definition The BLOOD BRAIN BARRIER [BBB] is a layer of tightly packed cells that make up the walls of brain capillaries and prevent substances in the blood from diffusing freely into the brain. The passage of substances across the cell membranes is determined by solubility in the lipid bilayer or recognition by a transport molecule [receptor]. THERE ARE MANY FORMS OF FOLATE The other many natural forms of folate [either eaten [DHF] or made by the body] do NOT get stuck in the FRa receptor sites…only Folic ACID and “Folate Receptor Auto-antibodies” can get stuck in the FRa receptors. THERE ARE SEVERAL DIFFERENT KINDS OF FOLATE RECEPTORS IN THE BODY Folate Receptor alpha [FRa] is the Folate receptor found on the BLOOD BRAIN BARRIER [BBB]. Too much FOLIC ACID and FOLATE Auto-ANTIBODIES…can be bad news When Folic ACID and or auto-antibodies against the FRa receptors get into the FRa receptors they can get stuck. When any of the NATURAL folates get into the FRa receptors on the BBB they can eventually disengage from the receptor and float away and the receptor is preserved for reuse. The supplement called Leukovorin [Folinic Acid] can also disengage and float away. LIGAND…definition The word ligand comes from the Latin word “ligandum” which means binding. A ligand [usually a small molecule] can form a complex with something else when it binds to the other object. TOO MUCH ….Folate ACID When Folic ACID [a synthetic man-made form of folate] gets attached to the FRa receptor on the BBB the complex becomes blocked. The Folic ACID molecule never gets into the brain and in the meantime it prevents the real thing [L-Methyl Folate] from getting into the brain. This is why too much Folic ACID is not good…it has nothing to do with interfering with the folate pathways. OTHER HELPFUL SUPPLEMENTS ZINC A little ZINC will help the Methionine Synthase [MS/MTR/MTRR] enzyme work to the best of their combined ability because Zinc is a necessary mineral that acts at the functional site of Methionine Synthase [MS/MTR]. The Zinc atom helps to coordinate all the participants in the reaction so that a methyl group gets attached to HOMOCYSTEINE thereby turning it into METHIONINE. LITHIUM ORATATE A little Lithium Oratate 2.5 to 5 mg a day will help B12 and folate get out of the blood stream and into our cells. A person may have a high B12 level in their blood stream but may not actually be getting that B12 or folate into their cells because of a lack of trace Lithium to be of assistance. Link to Post: https://www.facebook.com/editdoc.php?note_id=636743946415365 #MTHFR #L-METHYL FOLATE http://resqua.com/100005927200207/how-can-i-learn-some-basic-information-about-mthfr-and-l-methyl-folate

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Why does Dr. Amy Yasko include Folic ACID in some of her supplements?

2 years, 11 months ago

From Dr Carol Savage
MY GUESS:
Dr. Yasko may include the Folic ACID in some of her supplements...because there are perhaps individuals who never eat greens or beans, and whose gut is so messed up that they cannot digest greens or beans, and who avoid and never eat the processed foods that are already stuffed with Folic ACID.

The enzyme DiHydroFolate Reductase [DHFR] that converts DiHydroFolate [DHF] into THF can also convert Folic ACID into DHF.

If a person has a faulty "Folate Pathway" and is at risk for NOT making adequate DNA base pairs and they also have ... ..more

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how do i share my gene report with my doctor

3 years, 5 months ago

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgICxpZ8KDA Livewello FAQs Question: how do i share my gene report with my doctor Answer: First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps Then, share your #Livewello gene report with your Doctor (or anyone else): - Go to your online gene variance report at: https://livewello.com/snps - Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor - When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report. [They will be unable to view any other records in your Livewello account unless you shared it with them] Communicating with your Doctor: 1. Learn more about the Gene after generating your report: After generating your report click on any of the Genes in your report or the "i" icon in a Template. Livewello will link 8 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is available there. Information from each of these resources is composed to suit different styles of learning. Just copy and paste any useful info you find there, into the 'notes' or 'description' portion of your Gene Report. You can also print them directly. The important thing to remember is that, whenever you see something that interests you, always copy and paste that information and its browser link into your description. Clicking on the "Edit Title and Description” button in a Gene Template, allows you to add any information you gather. 2. Generate a Gene report based on your Diagnosis or health conditions and share it with your Doctor too at: https://livewello.com/gwas Follow the instructions above to save, then print this information. With the *personalized nature of health care that the field of Genetics encourages, it is prudent to take your Gene Report to your Healthcare Practitioner once it is generated. Just like they would any other Lab Report. Your Health Practitioner will be privy to first hand knowledge of how your complete health history, symptoms, physical evaluation and the global picture that other relevant Lab results will have on you, as an individual. We don't make anecdotal, blanket or personalized health recommendations for users. This is because, with over 600,000 SNPs in the human genome, genes express themselves entirely differently from one person to another. Our core mission for the Livewello Gene App lies in pairing accuracy in Variance reporting for a wider number of SNPs with an extensive resource for reliable information. Our goal is to democratize this reliable information by putting it at every user's finger tips. •http://en.wikipedia.org/wiki/Personalized_medicine 3. Share the information in this **sample standard Gene Report which has some good overview information: https://livewello.com/snps/share?for=martin.dawson.606 Share it with your Doctor too. *Remember: This sample report comes with only about 300 of the 600,000 SNPs in Livewello. This web application will give results for ALL the SNPs in your Raw Data that have rsIDs and Minor Alleles. The account needed to view the sample report is free. 4. Other things you should do with your 23andMe Raw Data: https://www.facebook.com/notes/livewello/about-livewellos-gene-app/863565933654629 5. Share all this information with your Healthcare Practitioners during your Appointment. Ask that it is added to your health records. More resources to share with your Doctor: a) Methylation Overview for Professionals http://www.drkendalstewart.com/wp-content/uploads/2011/09/Methylation-Overview-for-Professionals-10.11.pdf b) Information for Health Professionals http://www.kdheks.gov/newborn_screening/download/ACT/HCY_Info_for_Health_Professionals.pdf http://www.cdph.ca.gov/programs/nbs/Documents/NBS-DisordersDetectable011312.pdf c) Methylation Defects in Autism Disorders By Cindy Schneider M.D. http://www.center4autism.org/therapyMETH.asp d) Neil Rawlins 4-Part Video on MTHFR: http://www.youtube.com/watch?v=ZA8GUIRqIkE&sns=em e) MTHFR Related Health Problems by Stephen Smith M.D. http://www.mindmeister.com/12694596/mthfr-related-health-problems f) Heartfixer Online Dr. James Roberts: http://heartfixer.com/AMRI-Nutrigenomics.htm g) http://vimeo.com/81065604 http://resqua.com/100005927200207/how-do-i-share-my-gene-report-with-my-doctor

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Tips on Sharing your 23andMe Gene Report with your Doctor:

3 years, 6 months ago

YouTube

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgMCi74YKDA Livewello FAQs Question: Tips on Sharing your 23andMe Gene Report with your Doctor: Answer: First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps Then, share your #Livewello gene report with your Doctor (or anyone else): - Go to your online gene variance report at: https://livewello.com/snps - Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor - When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report. [They will be unable to view any other records in your Livewello account unless you shared it with them] Communicating with your Doctor: 1. Learn more about the Gene after generating your report: After generating your report click on any of the Genes in your report or the "i" icon in a Template. Livewello will link 8 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is available there. Information from each of these resources is composed to suit different styles of learning. Just copy and paste any useful info you find there, into the 'notes' or 'description' portion of your Gene Report. You can also print them directly. The important thing to remember is that, whenever you see something that interests you, always copy and paste that information and its browser link into your description. Clicking on the "Edit Title and Description” button in a Gene Template, allows you to add any information you gather. 2. Generate a Gene report based on your Diagnosis or health conditions and share it with your Doctor too at: https://livewello.com/gwas Follow the instructions above to save, then print this information. With the *personalized nature of health care that the field of Genetics encourages, it is prudent to take your Gene Report to your Healthcare Practitioner once it is generated. Just like they would any other Lab Report. Your Health Practitioner will be privy to first hand knowledge of how your complete health history, symptoms, physical evaluation and the global picture that other relevant Lab results will have on you, as an individual. We don't make anecdotal, blanket or personalized health recommendations for users. This is because, with over 600,000 SNPs in the human genome, genes express themselves entirely differently from one person to another. Our core mission for the Livewello Gene App lies in pairing accuracy in Variance reporting for a wider number of SNPs with an extensive resource for reliable information. Our goal is to democratize this reliable information by putting it at every user's finger tips. •http://en.wikipedia.org/wiki/Personalized_medicine 3. Share the information in this **sample standard Gene Report which has some good overview information: https://livewello.com/snps/share?for=martin.dawson.606 Share it with your Doctor too. *Remember: This sample report comes with only about 300 of the 600,000 SNPs in Livewello. This web application will give results for ALL the SNPs in your Raw Data that have rsIDs and Minor Alleles. The account needed to view the sample report is free. 4. Other things you should do with your 23andMe Raw Data: https://www.facebook.com/notes/livewello/about-livewellos-gene-app/863565933654629 5. Share all this information with your Healthcare Practitioners during your Appointment. Ask that it is added to your health records. More resources to share with your Doctor: a) Methylation Overview for Professionals http://www.drkendalstewart.com/wp-content/uploads/2011/09/Methylation-Overview-for-Professionals-10.11.pdf b) Information for Health Professionals http://www.kdheks.gov/newborn_screening/download/ACT/HCY_Info_for_Health_Professionals.pdf http://www.cdph.ca.gov/programs/nbs/Documents/NBS-DisordersDetectable011312.pdf c) Methylation Defects in Autism Disorders By Cindy Schneider M.D. http://www.center4autism.org/therapyMETH.asp d) Neil Rawlins 4-Part Video on MTHFR: http://www.youtube.com/watch?v=ZA8GUIRqIkE&sns=em e) MTHFR Related Health Problems by Stephen Smith M.D. http://www.mindmeister.com/12694596/mthfr-related-health-problems f) Heartfixer Online Dr. James Roberts: http://heartfixer.com/AMRI-Nutrigenomics.htm http://resqua.com/100005927200207/tips-on-sharing-your-23andme-gene-report-with-your-doctor

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How can I get get my Doctor to understand my gene report?

3 years, 6 months ago

Physicians don't always know what to do with your genetic information because epigenetics and pharmacogenomics are relatively new fields, and everyone is trying to catch up. Also Traditional/Allopathic physicians have very limited time in which to go over all the information that you hand over to them, so the best way to present them with new information like this, is to share a link to your Report and make sure you tell them to read the associated medical references that come with your App. For instance, every Gene in the LiveWello Gene App report is directly linked to ... ..more

Vimeo

ag5zfnJlc291cmNlLXFuYXITCxIGQW5zd2VyGICAgIDXpZkKDA Genetics & Health Question: How can I get get my Doctor to understand my gene report? Answer: Physicians don't always know what to do with your genetic information because epigenetics and pharmacogenomics are relatively new fields, and everyone is trying to catch up. Also Traditional/Allopathic physicians have very limited time in which to go over all the information that you hand over to them, so the best way to present them with new information like this, is to share a link to your Report and make sure you tell them to read the associated medical references that come with your App. For instance, every Gene in the LiveWello Gene App report is directly linked to several authoritative reference resources like Genetics Home Reference, SNPedia, Medline, Pubmed and OMIM. If your doctor knows how to access this information in your report, it will help them make more sense of it and consequently help them help you better. Just so you know, when you click on a Gene in your #Livewello report to get more info, those 8 resource links have information to suit different learning styles. GHR, Medline, OMIM, PubMed and WikiGenes are favorites. Copy and paste any info you find into the "Annotate/"Notes" portion of your report. You can also print them directly from those resources because based on their credibility, your Doctor is more likely to respect the resources and pay attention to the info. Another idea is to use the Health Conditions tool in your Livewello Gene App. It is free: https://livewello.com/gwas Search for any of your Health issues. This tool uses Genome wide Research Study tool to generate your results on Genes associated with certain Health issues. This video of this tool is helpful: http://vimeo.com/103746466 Hand all this information to your Doctor during an appointment and ask that it is added to your Health Records. Here is sample Gene Report for MTHFR with information and resources to learn more: https://livewello.com/snps/library?action=preview&index=184646&for=demo http://resqua.com/100005927200207/how-can-i-get-get-my-doctor-to-understand-my-gene-report

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