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Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

Annonymous

How can I stimulate my vagus nerve

  1 year, 9 months ago

SOURCE: http://selfhacked.com/2015/...


Introduction to The Vagus Nerve

In people with fatigue, food sensitivities, anxiety and gut problems, brain fog and depersonalization, the vagus nerve is almost always at play. These people have lower vagal tone, which means a lower ability of the vagus nerve to activate.

The only question is what aspect of the vagus nerve is malfunctioning and how much the vagus nerve is a problem vs. other aspects of your biology.

The vagus nerve is part of the parasympathetic nervous system, referred to as the rest and digest system. It’s not the only nerve ... ..more

Vitamin B12 is one of the most frequently prescribed treatments in chronic fatigue syndrome (ME/CFS) yet it is not uncommon
for it to perform poorly or even to have negative effectsthus. Here Fred provides some of the reasons he believes B12 does not sometimes work in ME/CFS

Taking It in Tablet Form- Active b12 is taken as an oral tablet reducing its absorbtion to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to ... ..more

1) Get a Standard Health Report. Go to https://livewello.com/snps and upload your raw data gene results file.

How does the Livewello App work with your Genetic Raw Data?
https://docs.google.com/a/l...

2) Get a Healthcare Practitioner who is qualified and understands Epigenetics.
Share your Report with your Healthcare Practitioner
Since a software application doesn't know your unique symptoms, your other functional lab levels and a host of your other important health variables, it would be unsafe for it to dispense a safe treatment plan without this information. What you'll need next is ... ..more

Annonymous

What is SNP Sandbox?

  2 years, 2 months ago

The Sandbox tool is for creating an unlimited number of customized Health Reports with your raw data from 23andMe AncestryDNA or most other personal genomics testing companies. You can use it to create a customized report based on any Gene or SNP name you want added to it. It works best once you upload your raw data file.

This tool allows you to add thousands of SNPs of YOUR choice to your Report. You can use it to add SNPs to your Report that are not in your Standard Variance Report. So, if you've received your 23andMe, Ancestry, FTDNA ... ..more

You probably have done your Gene Test for a variety of reasons that may not have included your health. Did you know that your Gene results contain information about mutations that research has associated with certain health issues? This information can include your potential risk for certain health conditions. Of course, we always advise that any information our software provides for you is discussed with your Doctor but it is important to maximize the information in your Gene results. Read: Methylation: Why It Matters For Your Immunity, Inflammation & More

6 Ways A DNA Test Can Help You Optimize Your Diet

Matching Genes and Vitamins. A Personalized Plan May Be in Your Future

Why would you need to run a Genetics test?
https://docs.google.com/doc...

LiveWello is unique because it gives you much more than just a Gene report: The Livewello Gene App will give you Gene reports for 600,000 SNPs and conveniently attaches 12 resources for learning to each Gene. The App also offers free updates that reflect your results when 23andMe adds more SNPs to your raw data. The reason for this feature, is that we believe that people should have information for all the Genes in their Raw Data not just some of them. That way, you and your Heallthcare Practitioner can have the benefit of all this information when creating your treatment plan. Basically, as long as a SNP is in your Raw Data with rsID and Minor Allele, the App will generate your Gene Report for it.
So, how does the Livewello App work ?
1) Download your Raw Data from 23andMe, Ancestry.com or FTDNA etc. Save it to your desktop.
2) Go to the home page at: https://livewello.com/genetics
On that page, you can learn more about our genetics tools. Then, click the "Get Started" button to upload your raw data and pay the 1-time fee of 19:95. The raw data file you upload into the App should not be altered in any way. i.e. Do not edit the file name, file format or contents.
3) Livewello currently gives you unlimited Health reports for about 600,000 SNPs in your Raw Data. Once you’re done with uploading your raw data, you can start generating your Health Reports with these free tools:
a) The Gene Library is searchable and has thousands of FREE Health Reports you will find helpful and can download: https://livewello.com/snps/...
It is designed to give your health reports on Genes that Research Studies have associated with your health issues and Diagnosis. Share your reports with your Doctor. These Gene Reports could be good indicators that your Doctor may need to order further lab/diagnostic testing. As a Livewello Gene App user, you can install as many Gene Reports as you'd like. There is no limit!

b) The GWAS Health Conditions Tool
If you don’t see Gene Reports about your health issues in the Gene Library, use this tool:
It will give you health reports on Genes that Research Studies have associated with your health issues and Diagnosis: https://livewello.com/gwas

DIRECTIONS FOR THE GWAS Health Conditions FEATURE
To use the GWAS Health Conditions Tool go to https://livewello.com/gwas
i. Simply enter the health condition's name to see if any Genome-wide studies have been done on that condition. If studies exist, as you type, results will come up. Click on the result that matches your search.
ii. Click on "copy to SNP sandbox" and
iii. Click "build template" and "view report" to generate a report for yourself.
c) The SNP Sandbox Tool Use it to create customized Gene Reports based on any Gene or SNP names you choose to have in it. How-To Video: http://vimeo.com/103512972
EXAMPLES: YASKO'S NUTRIGENOMIC SNPs: https://livewello.com/snps/...
MTHFR Gene SNPs ... ..more

Vimeo

A Standard Gene Report with information looks like this:  https://livewello.com/snps/... This sample contains some useful info worth sharing with your Doctor.

1) When your Gene report is created, click the Gene itself (or the "i" icon in a Template). Livewello will link 12 Learning Resources directly to each of the Genes in your report. They are: Medline, GHR, Google Scholar, dbSNP, Ensembl, Wiki Genes, SNPedia Wiki Genes, Malacards and PubMed. If the info is not readily available, re-enter your gene name or health condition into that resource's search box to check if any further information is ... ..more

Vimeo

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

By Carol Savage
"Is it possible for people to be low in L-Methyl Folate [5-MTHF] even if they do NOT have single nucleotide polymorphisms affecting the MTHFR enzyme?"

The answer is... YES.

DIET
A person can have terrible nutrition. Someone who doesn't eat anything green. Someone who never eats beans. A poor diet low in DiHydroFolate [DHF] can cause there to be insufficient L-Methyl Folate.

MEDICATIONS
This includes thousands of people on coumadin [warfarin] who avoid eating greens and people with Rheumatoid Arthritis [RA] who have been given Methotrexate. Methotrexate blocks the enzyme that converts DHF into TetraHydroFoalte [THF ... ..more

MTHFR C677T and A1298C…how they don't work correctly By Carol Savage
………………….

MTHFR C677T...METHYLATION CYCLE...Epigenetics [SAMe and methylation of our DNA]

The MTHFR C677T snps causes the enzyme to be unable to utilize the cofactor FAD/FADH2 properly. The snp mistake [C677T] causes the enzyme to be temperature labile. As a result, the cofactor FAD disengages and subsequently L-Methyl Folate [5-MTHF] cannot be made. So, MTHFR C677T interferes with the forward action of the MTHFR enzyme and subsequently interferes with the conversion of Homocysteine into Methionine and the making of SAMe.

L-Methyl Folate is most beneficial to ... ..more

SENSITIVITY TO METHYL DONORS By Carol Savage

Those who are very sensitive to methyl donors have to supplement with low dosages of different kinds of B12 and folate. Rotating them is likely the best approach.

They need to give their body TIME of accept the supplements, TIME to allow the biochemistry to adjust before adding in more...sometimes even skipping days when no supplements are taken.

A gentle approach is the best way to proceed if you are sensitive to methyl donors.
Link: https://www.facebook.com/gr...
#Methyl Donors #MTHFR ..more

MTHFR and L-METHYL FOLATE… Some Basic Information By Carol Savage M.D.

If you have the MTHFR Gene Mutations C677T and or A1298C and are already taking some L-Methyl Folate [5-MTHF] and Vitamin B12 you might also consider the following:

FOOD Eat plenty of Green Vegetables and beans to get some Dihydrofolate [DHF] and Vitamin B2 [Riboflavin] and many other naturally occurring minerals and vitamins that the body needs etc.

DIHYDROFOLATE [DHF] Dihydrofolate is needed to provide the earlier FOLATE PATHWAYS [the reactions that occur prior to the MTHFR enzyme] with the kinds of folates that they need in order ... ..more

From Dr Carol Savage
MY GUESS:
Dr. Yasko may include the Folic ACID in some of her supplements...because there are perhaps individuals who never eat greens or beans, and whose gut is so messed up that they cannot digest greens or beans, and who avoid and never eat the processed foods that are already stuffed with Folic ACID.

The enzyme DiHydroFolate Reductase [DHFR] that converts DiHydroFolate [DHF] into THF can also convert Folic ACID into DHF.

If a person has a faulty "Folate Pathway" and is at risk for NOT making adequate DNA base pairs and they also have ... ..more

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

First, generate your 23andMe Gene Report by uploading your Raw Data to: https://livewello.com/snps

Then, share your #Livewello gene report with your Doctor (or anyone else):
- Go to your online gene variance report at: https://livewello.com/snps
- Just above the report there is a URL in a text box. Copy this URL and paste it into an email to your doctor
- When your Doctor (or anyone else) clicks on this link, they will be taken to a page which displays your report.
[They will be unable to view any other records in your Livewello account unless you ... ..more

YouTube

Physicians don't always know what to do with your genetic information because epigenetics and pharmacogenomics are relatively new fields, and everyone is trying to catch up.  Also Traditional/Allopathic physicians have very limited time in which to  go over all the information that you hand over to them, so the best way to present them with new information like this, is to share a link to your Report and make sure you tell them to read the associated medical references that come with your App. For instance, every Gene in the LiveWello Gene App report is directly linked to ... ..more

Vimeo