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Mitochondria (illustration) are structures within cells that convert the energy from food into a form that cells can use. Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA (known as mitochondrial DNA or mtDNA). In some cases, inherited changes in mitochondrial DNA can cause problems with growth, development, and function of the body’s systems. These mutations disrupt the mitochondria’s ability to generate energy efficiently for the cell.

Conditions caused by mutations in mitochondrial DNA often involve multiple organ systems. The effects of these conditions are most pronounced ... ..more

Annonymous

What can be done to increase Calcium ?

  4 years, 3 months ago

Lab Tests indicating a need to increase #Calcium:
#Calcium below the range of low end normal on a urine essential test
Calcium below the range of low end normal on a RBC element test
High level excretion of #lead should check urine calcium levels

Supplements to increase Calcium:
Bone Support Formula RNA
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Nettle
#Chamomile
#Chervil
Cal/Mag/VitD/VitK -Calcium & Magnesium Citrates
Don Quai - Max V
Black Cohosh
#Prevagen 5mg or less
 ..more

Annonymous

What is ACAT Gene Mutation

  4 years, 3 months ago

ACAT Acetyl-Coenzyme A acetyltransferase AKA A bad Gut & Oxalates issues. This is Priority mutation # 2.

Although this mutation is fairly uncommon, it significantly impacts the Energy Cycle (citric acid cycle) and mitochondrial function. The influences are wide and far ranging and include bile salt production, cholesterol, fatty acids, and the processing of oxalates. Notwithstanding a partial or full defect, many have a “functional” variation due to the impact of aluminum, heavy metals, and toxins as well as other defects that impact this area such as the NOS, MTHFR, & CBS. Upon viewing the methylation community diagram, it is important to note that the energy cycle is closely connected to each sequence, yet it is intimately linked to both the waste cycle and SAM’s Corporation.

Since the energy cycle is essential for processing and converting all dietary nutrients (glucose, fats, proteins) into useable forms of energy, a breakdown anywhere down the line might trip an internal alarm. This is analogous to your car’s “low fuel” gauge. Just as any industry processes coal, gas, or oil for energy production, your body must have the essential nutrients in order to properly function. If you visualize the energy cycle as a clock, each hour represents an area in which one nutrient or substance converts into a more compatible form of energy. Depending on digestive function, diet, rate of absorption, and the presence of any genetic quirks, a problem might occur at any point within the device. This may lead to significant chemical imbalances within your body chemistry as well as mitochondrial dysfunction or disorders.

The ACAT plays a key role in creating bile salts, which is crucial for cholesterol and other membrane lipid balances. While we tend to view cholesterol and other fats as the “bad guys” in the war against disease, these compounds are critical for general health and wellbeing. Whether it’s the coating surrounding a nerve, cell, or organ, cholesterol is essential in its production. Think of your home’s electrical wiring and the thick, plastic or rubber coating normally found protecting it. An exposed wire is vulnerable and may “short out,” so that the impulse isn’t transmitted. Similarly, the body’s nervous system requires the protection afforded from a nice, thick fatty coating or fundamental connections may never be made. An exposed nerve may lead to a misfire, which is often the source behind the early symptoms found in neuroimmune disorders. This often includes signs such as tremors, muscle fasciculations, weakness, and fatigue as well as word groping and poor concentration and retention. Without cholesterol, you also cannot make several vital hormones, including, your sex hormones (estrogen & testosterone) or insulin. Therefore, low cholesterol levels are not as beneficial as one would initially think.

Finally, if a chronically ill person has had heavy aluminum or other toxic exposures along with a partially functioning ACAT, energy production is likely to stall to a near standstill. Moreover, as outlined in the energy cycle, other problems may include:
1. More B-12 depletion, which has ramifications throughout the entire system.
2. Cholesterol & fatty acid imbalances, often leading to toxic fatty acid buildup & high cholesterol.
3. Decreasing bile salts & increased taurine production as well as poor cell wall function since they all rely
on the proper breakdown of cholesterol through the ACAT.
4. Poor breakdown of fats, carbohydrates, & proteins to fuel other cells, nerves, tissue, & organs.
5. Rising oxalate levels that may cause painful urination and bladder & kidney stones.
6. Co Q-10 reduction, which is also necessary for mitochondrial function & energy.
7. Limited energy for the Waste Facility & SAM’s Corp. due to less conversion of methionine to SAMe. In
having over 400 methylation functions, SAMe is critical for the entire community.
As the energy factories of each cell, mitochondrial damage has significant implications. In fact, anything that demands more energy, including the gut and the brain, are particularly vulnerable. Significant blocks may limit the availability of bile salts; hence the digestive process is doubly burdened. This provides a valid reason for many unexplained digestive problems, while explaining poor growth & development as well as failure to thrive. Well-studied toxins such as aluminum, lead, mercury, and MSG also greatly impact this factory. This is one reason those with known mitochondrial disorders are discouraged from eating foods with pesticides, MSG, and aluminum. Ultimately, anyone with multiple risk factors is especially prone to mitochondrial dysfunction.

Labs:
Monitor for oxalates, high taurine, MMA, and/or methionine levels as well as low cholesterol.
Ethanolamine and the ... ..more

Adverse reactions to fluoroquinolone #antibiotics ( #Cipro #Ciprofloxacin #Levaquin #Levofloxacin #Avelox #Moxifloxacin and #Floxin #Ofloxacin ) can manifest in patients as a multi-symptom chronic illness that most resembles #fibromyalgia #chronic fatigue syndrome #CFS / #myalgic encephalopathy (ME) and/or an #autoimmune diseases. As is the case with those chronic multi-symptom illnesses, the symptoms of fluoroquinolone toxicity vary greatly from one individual to another. Though almost everyone who suffers from fluoroquinolone toxicity has some sort of musculoskeletal issues (fluoroquinolones have a black box warning about the risk of tendon rupture), #neuropathy and autonomic nervous system dysfunction, those broad categories of symptoms are where the ... ..more

Lab Tests indicating a need to decrease #Calcium :
Elevated calcium relative to magnesium on a urine essential element test
Elevated calcium relative to magnesium on a red blood cell element test
Stims

#Supplements to help address high Calcium:
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Magnesium
Chamomile
Boswellia -Ayur Boswellia Serrata
Vinpocetine
Zinc
Paradex
Don Quai - Max V
Air Power
Black Cohosh
Prevagen 5mg or less ..more

There is little known about the A1298C MTHFR mutation. Or so it seems.
Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory.
For those who have the A1298C MTHFR mutation, this is frustrating.
Symptoms exist and doctors are saying there is no correlation between the MTHFR A1298C mutation and your symptoms – right?

I’d like to prove them wrong – at least for the symptoms which do correlate with the A1298C MTHFR mutation.

The MTHFR A1298C mutation may affect you if you are either:
--Homozygous A1298C MTHFR mutation
--Compound heterozgous A1298C + C677T ... ..more


By Caledonia
1-21-2014

ME/CFS patients are notoriously very sensitive to medicines and supplements. It’s common to have adverse reactions, or to only be able to tolerate small doses.
Newbies are especially prone to taking too large of doses or going too fast. The following explains how to manage such sensitivity.

Start Low and Go Slow

Whenever you start a new medicine or supplement, it is suggested to practice Start Low and Go Slow.

This means starting with very small doses, much less than a normal dose, such as 1/8 of pill. That way, if you're going ... ..more

YouTube

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Understanding #chronic #fatigue Syndrome #CFS

I left the Mayo Clinic in 2007 a little relieved, a little angry and very poor. Now, I know exactly why I was angry after watching the series of videos below (more about that later). Unfortunately, my anger at being diagnosed with Chronic Fatigue prevented me from doing my own research – I was fed up and I just retreated to my cave for five years to try to heal with diet and lifestyle improvements. That was a big mistake because it appears that a number of researchers have figured out chronic fatigue. If you’ve ... ..more

Vimeo

Elevated calcium relative to magnesium on a urine essential element test
Elevated calcium relative to magnesium on a red blood cell element test
Stims

Supports to help address high Calcium:
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Magnesium (Low dose in MetalAway, MTR/MTRR/SUOX and MitoForce)
Chamomile
Boswellia -Ayur Boswellia Serrata (In Inflammation compound-coming)
Vinpocetine
Zinc (Low dose In NaturoMycin Spray, SeroMood and PeptiMycin)
Paradex (In NaturoMycin Caps)
Don Quai - Max V
Air Power
Black Cohosh
Prevagen 5mg or less ..more

What does this process look like when it’s broken? After reading the following, you will be able to envision the implications of defects or mutations. The following is an example of the health problems that might occur.
1. Poor nerve function leads to muscle twitching, numbness, and weakness yet misfires can cause seizures, fatigue, memory loss, word groping, clumsiness (with falls & injuries), and visual or hearing loss in those with MS, CFS/ME, or Autism Spectrum Disorders.

2. Depending on the neuro-talker, imbalances often lead to a variety of disorders including: depression, anxiety, panic attacks, irritability, mood swings, OCD ... ..more

Annonymous

What is the Krebs Cycle?

  4 years, 3 months ago

The Energy or Citric Acid Cycle:
The Krebs cycle, also called the citric acid cycle or the “Energy Cycle,” is a series of chemical reactions that convert food (sugar, protein, and fat) into energy (ATP). It is referred to as a cycle since it should always end where it began. This process occurs through three main stages within each cell:

1). Glycolysis, otherwise known as the breakdown of sugar, yields 2 molecules of ATP, 2 molecules of NADH, and two forms of pyruvate (6 forms of currency in all). This is actually a step that takes place before the energy ... ..more

YouTube

Annonymous

What is Sympathetic

  4 years, 3 months ago

SNS Dominants, AKA “Type A” – Otherwise known as “Carbo types”, “Slow oxidizers” & “Sympathetic dominant”. This simply means that they slowly break down meals (whole grains, fruits, veggies & lean proteins) in order to obtain the necessary energy required for their more active lifestyles. Food may sit “like a rock” in their guts so that they remain full much longer than they should. They generally have weak appetites (forgetting to eat at times) and a high tolerance for sweets. They are often "type A" personalities who may be dependent on caffeine. When not functioning optimally, they may feel agitated, "wired" or "on ... ..more

Vimeo

To find out if your #gut is #metabolizing or #absorbing #fat you can have your doctor run a Fecal fat and a #Sehcat test for #bile acid #malabsorption
Reasons can be Low #triglycerides, low #cholesterol , #choline deficiency, #FattyLiver......

Malabsorption can be described as the body’s inability to absorb certain nutrients from the #gastrointestinal ( #GI ) tract. This problem has become one of the leading health concerns all across the US today. There are several different types of malabsorption syndromes and the most common ones include the inability to absorb fat, proteins, vitamins and sugar. The different factors that could lead ... ..more

Annonymous

What is Dopamine ?

  4 years, 3 months ago

Think “delightful dialogue” with #dopamine since this #neurotransmitter is crucial for happiness, a sense of wellbeing, and language. It’s also involved in #muscle control and function. Dopamine is responsible for #motivation , interest, #mood , #speech , and contentment. It is also associated with positive #stress states such as being in love, exercising, listening to music, and of course, #sex . When you don't have enough dopamine, you may have difficulty initiating or completing tasks. Deficiencies also lead to poor #concentration , little or no energy, and lack of motivation. This could be the culprit if you lack the initiative to study the ... ..more

MTHFR C677T Mutation: Basic Protocol by Dr Lynch on February 24, 2012 in C677T MTHFR Mutations
Have one or two copies of the MTHFR C677T mutation? Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.
I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of ... ..more

Acetylcholine is known as the inhibitory #Neurotransmitter System
The first #neurotransmitter to be discovered in 1921. Its’ importance lies in the fact that it stimulates muscles to contract. This NT alters heart muscle contractions and impacts muscle function throughout the body. It’s also strategic in vocalizations/ #speech and #swallowing . Acetylcholine is critical for #attention , #alertness , and #memory . People with #Alzheimer’s , #Parkinson’s , #ALS , and #Myasthenia Gravis have substantial #dysfunction within acetylcholine activity or breakdown.

Low levels are associated with #depression , and a lack of #concentration & #emotion as well as poor #muscle tone, #forgetfulness , and poor #sleep “light sleepers ... ..more

Annonymous

How does HISTAMINE affect you?

  4 years, 3 months ago

#HISTAMINE RECEPTORS
http://healthypixels.com/wp...

Most of us know histamines through #antihistamine drugs that relieve our suffering from #allergies to pollen, insect bites, and even foods.
Histamine is naturally produced in our body by #mastcells or white blood cells.
Histamine performs different functions by binding with histamine receptors. Depending upon their location, histamine receptors control very different body functions:

Histamine #H1 receptors:
Smooth muscle and endothelial cells affecting skin; blood vessels (Benadryl and Claritin block activity of these receptors)

Histamine #H2 receptors:
Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate
(Histamine H2 receptor antagonist ... ..more

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This question is hidden

Calcium below the range of low end normal on a urine essential test
Calcium below the range of low end normal on a RBC element test
High level excretion of lead should check urine calcium levels

Supports to increase Calcium:
Bone Support Formula RNA
MitoForce Compounded Supplement
CoEnzyme Q10 Fatigue & Muscle Support Spray
GSH Capsules
Nettle (In Calm Down-Gaba/Glutamate Spray)
#Chamomile
Chervil
Cal/Mag/VitD/VitK -Calcium & Magnesium Citrates
Don Quai - Max V
Black Cohosh
Prevagen 5mg or less
 ..more